Alternatived Products of [ 6744-85-0 ]
Product Details of [ 6744-85-0 ]
CAS No. : | 6744-85-0 |
MDL No. : | MFCD00090729 |
Formula : |
C9H7NO6
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
225.16
|
Pubchem ID : | - |
Synonyms : |
|
Application In Synthesis of [ 6744-85-0 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Upstream synthesis route of [ 6744-85-0 ]
- Downstream synthetic route of [ 6744-85-0 ]
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[ 186581-53-3 ]
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[ 603-11-2 ]
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[ 6744-85-0 ]
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[ 13365-26-9 ]
- 2
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[ 67-56-1 ]
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[ 603-11-2 ]
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[ 6744-85-0 ]
- 3
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[ 641-70-3 ]
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[ 124-41-4 ]
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[ 6744-85-0 ]
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[ 21606-04-2 ]
- 4
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[ 641-70-3 ]
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methanolic KOH-solution
[ No CAS ]
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[ 6744-85-0 ]
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[ 21606-04-2 ]
- 5
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[ 7719-09-7 ]
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[ 21606-04-2 ]
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[ 6744-85-0 ]
- 6
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[ 7719-09-7 ]
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[ 6744-85-0 ]
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[ 21606-04-2 ]
- 7
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[ 75-09-2 ]
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[ 6744-85-0 ]
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[ 40963-14-2 ]
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Methyl N-(1-carbamoyl-1,2-dimethylpropyl)-6-nitrophthalamate
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
With triethylamine; In tetrahydrofuran; thionyl chloride; water; ethyl acetate; toluene; |
EXAMPLE 10 Methyl N-(1-carbamoyl-1,2-dimethylpropyl)-6-nitrophthalamate STR56 A suspension of 4.94 g 2-methyl 3-nitrophthalate in 20 mL thionyl chloride is stirred at room temperature for 72 hours. The mixture is concentrated and the residue dissolved in toluene and again concentrated. This process is repeated. The residue (crude acid chloride) in 30 mL dry THF is added dropwise at room temperature with stirring under nitrogen to a solution containing 3.84 g <strong>[40963-14-2]2-amino-2,3-dimethylbutyramide</strong> and 4.4 mL triethylamine in 50 mL dry THF. After stirring at room temperature for 24 hours, 50 mL water and 50 mL CH2 Cl2 is added, the phases separated and the aqueous phase reextracted with 50 mL ethyl acetate. The combined organic extract is dried and concentrated. The residue is triturated with ether to give the product which is recrystallized from ethyl acetate to give the desired product with mp 100-107 C. |
|
With triethylamine; In tetrahydrofuran; thionyl chloride; water; ethyl acetate; toluene; |
EXAMPLE 10 Preparation of methyl N-(1-carbamoyl-1,2-dimethylpropyl)-6-nitrophthalamate STR21 A suspension of 4.94 g 2-methyl-3-nitrophthalate in 20 ml thionyl chloride is stirred at room temperature for 72 hours. The mixture is concentrated and the residue dissolved in toluene and again concentrated. This process is repeated. The residue (crude acid chloride) in 30 ml dry THF is added dropwise at room temperature with stirring under nitrogen to a solution containing 3.84 g <strong>[40963-14-2]2-amino-2,3-dimethylbutyramide</strong> and 4.4 ml triethylamine in 50 ml dry THF. After stirring at room temperature for 24 hours, 50 ml water and 50 ml CH2 Cl2 is added, the phases separated and the aqueous phase reextracted with 50 ml ethyl acetate. The combined organic extract is dried and concentrated. The residue is triturated with ether to give the product which is recrystallized from ethyl acetate to give the desired product with mp 100-107 C. |
- 8
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[ 6744-85-0 ]
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[ 603-11-2 ]
- 9
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[ 6744-85-0 ]
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[ 34529-06-1 ]