Home Cart Sign in  
Chemical Structure| 676491-50-2 Chemical Structure| 676491-50-2

Structure of 676491-50-2

Chemical Structure| 676491-50-2

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 676491-50-2 ]

CAS No. :676491-50-2
Formula : C12H10N4O
M.W : 226.23
SMILES Code : COC1=CN=C(C2=NC=CN=C2)C3=C1C=CN3
MDL No. :MFCD26407042

Safety of [ 676491-50-2 ]

Application In Synthesis of [ 676491-50-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 676491-50-2 ]

[ 676491-50-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 619331-35-0 ]
  • (2-pyrazinyl)tributyltin [ No CAS ]
  • [ 676491-50-2 ]
YieldReaction ConditionsOperation in experiment
53% copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); In DMF (N,N-dimethyl-formamide); at 90℃; for 4h; [0691] A mixture of <strong>[619331-35-0]7-bromo-4-methoxy-6-azaindole</strong> (1.160 g, 5.11 mmol) and 2-(tri-n-butylstannyl)pyrazine (2.07 g, 5.62 mmol) in 25 mL of dry DMF was degassed with a stream of Ar bubbles for 10 min. To this solution was added tetrakis(triphenylphosphine)palladium (0.590 g, 0.511 mmol) and CuI (0.097 g, 0.511 mmol) and the mixture was heated in a sealed tube at 90 C. for 4 h. The cooled mixture was filtered through methanesulfonic acid SCX cartridges (7×3 g) with MeOH, to remove triphenylphosphine oxide. The filtrate was evaporated and the residue triturated with MeOH to give the title compound (0.612 g, 53%) as a light yellow solid: [0692] 1Hnmr (400 MHz, DMSO-d6) δ 11.79 (br s, 1H), 9.63 (d, J=1.5 Hz, 1H), 8.75 (m, 1H), 8.64 (d, J=2.6 Hz, 1H), 8.04 (s, 1H), 7.56 (dd, J=3.0, 2.6 Hz, 1H), 6.64 (dd, J=3.0, 2.0 Hz, 1H), 4.08 (s, 3H). [0693] LCMS: m/e 227 (M+H)+.
  • 2
  • [ 619331-35-0 ]
  • Ar [ No CAS ]
  • (2-pyrazinyl)tributyltin [ No CAS ]
  • [ 676491-50-2 ]
YieldReaction ConditionsOperation in experiment
53% With CuI;tetrakis(triphenylphosphine) palladium(0); In N,N-dimethyl-formamide; Preparation of 4-Methoxy-7-pyrazinyl-6-azaindole: A mixture of <strong>[619331-35-0]7-bromo-4-methoxy-6-azaindole</strong> (1.160 g, 5.11 mmol) and 2-(tri-n-butylstannyl)pyrazine (2.07 g, 5.62 mmol) in 25 mL of dry DMF was degassed with a stream of Ar bubbles for 10 min. To this solution was added tetrakis(triphenylphosphine)palladium (0.590 g, 0.511 mmol) and CuI (0.097 g, 0.511 mmol) and the mixture was heated in a sealed tube at 90 C. for 4 h. The cooled mixture was filtered through methanesulfonic acid SCX cartridges (7*3 g) with MeOH, to remove triphenylphosphine oxide. The filtrate was evaporated and the residue triturated with MeOH to give the title compound (0.612 g, 53%) as a light yellow solid: 1Hnmr (400 MHz, DMSO-d6) δ 11.79 (br s, 1H), 9.63 (d, J=1.5 Hz, 1H), 8.75 (m, 1H), 8.64 (d, J=2.6 Hz, 1H), 8.04 (s, 1H), 7.56 (dd, J=3.0, 2.6 Hz, 1H), 6.64 (dd, J=3.0, 2.0 Hz, 1H), 4.08 (s, 3H). LCMS: m/e 227 (M+H)+.
 

Historical Records

Technical Information

Categories