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[ CAS No. 676515-34-7 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 676515-34-7
Chemical Structure| 676515-34-7
Structure of 676515-34-7 *Storage: {[proInfo.prStorage]}

Quality Control of [ 676515-34-7 ]

Related Doc. of [ 676515-34-7 ]

SDS

Product Details of [ 676515-34-7 ]

CAS No. :676515-34-7MDL No. :MFCD12024514
Formula : C8H7BrN2O Boiling Point : 373.6°C at 760 mmHg
Linear Structure Formula :-InChI Key :N/A
M.W :227.06Pubchem ID :40152202
Synonyms :

Computed Properties of [ 676515-34-7 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 676515-34-7 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 676515-34-7 ]

  • Downstream synthetic route of [ 676515-34-7 ]

[ 676515-34-7 ] Synthesis Path-Downstream   1~10

  • 1
  • [ 676515-34-7 ]
  • (E)-4(1H)-hydroxyimino-6-bromo-2,3-dihydro-1,8-naphthyridine [ No CAS ]
  • 2
  • [ 676515-33-6 ]
  • [ 676515-34-7 ]
  • 3
  • [ 1023813-80-0 ]
  • [ 676515-34-7 ]
  • 4
  • [ 676515-34-7 ]
  • 6-bromo-4,4-difluoro-1,2,3,4-tetrahydro-[1,8]naphthyridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
86.2 mg With diethylamino-sulfur trifluoride; In dichloromethane; for 108h; The <strong>[676515-34-7]6-bromo-2,3-dihydro-1H-[1,8]naphthyridin-4-one</strong> (82.8 mg, 0.36 mmol) is dissolved into 1 mL of CH2Cl2 and 5 mL of diethylamino sulfur trifluoride. The mixture is stirred for 4.5 days. The mixture is quenched by slow addition of the mixture to ice. The solution is neutralized with the slow addition of saturated aqueous NaHCO3. This is diluted with 50 mL EtOAc, washed with 2×20 mL of H2O and 1×20 mL of brine. The organic phase is dried with MgSO4, filtered and concentrated. The crude material is applied to a silica preparative TLC plate and eluted with 70% EtOAc/hexanes to give 86.2 mg of 6-bromo-4,4-difluoro-1,2,3,4-tetrahydro-[1,8]naphthyridine
  • 5
  • 6-bromo-4-oxo-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid tert-butyl ester [ No CAS ]
  • [ 676515-34-7 ]
YieldReaction ConditionsOperation in experiment
386 mg With hydrogenchloride; In 1,4-dioxane; methanol; for 16h; 6-Bromo-4-oxo-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid tert-butyl ester (628 mg, 1.92 mmol) is dissolved into 3 mL of MeOH and 3 mL of 4 M HCl/ 1,4-dioxane is added. The mixture is stirred for 16 h and concentrated to dryness. The residue is dissolved into 10 mL CH2Cl2 and 10 mL of H2O and neutralized with saturated aqueous Na2CO3 solution. The aqueous layer is extracted with 2×20 mL of CH2Cl2. The organic phase is dried with MgSO4, filtered and concentrated to give 386 mg of <strong>[676515-34-7]6-bromo-2,3-dihydro-1H-[1,8]naphthyridin-4-one</strong>
  • 6
  • [ 335030-38-1 ]
  • [ 676515-34-7 ]
  • 7
  • [ 676515-34-7 ]
  • 4,4-difluoro-6-pyridin-3-yl-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid amide [ No CAS ]
  • 8
  • [ 676515-34-7 ]
  • 6-bromo-4,4-difluoro-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid amide [ No CAS ]
  • 9
  • [ 676515-34-7 ]
  • [ 1613147-66-2 ]
  • 10
  • [ 676515-34-7 ]
  • [ 1613147-67-3 ]
Historical Records

Related Functional Groups of
[ 676515-34-7 ]

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Ketones

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Related Parent Nucleus of
[ 676515-34-7 ]

Other Aromatic Heterocycles

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