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Chemistry
Heterocyclic Building Blocks
Pyridazines
Methyl-6-chloro-4-methoxypyridazine-3-carboxylate
Chemistry
Heterocyclic Building Blocks
Organic Building Blocks
Pyridazines
Chlorides Esters Ethers

[ CAS No. 679405-85-7 ] {[proInfo.proName]}

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Chemical Structure| 679405-85-7
Chemical Structure| 679405-85-7
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COA NMR CNMR HPLC LC-MS

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Product Details of [ 679405-85-7 ]

CAS No. :679405-85-7 MDL No. :
Formula : C7H7ClN2O3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 202.60 Pubchem ID :-
Synonyms :

Safety of [ 679405-85-7 ]

Signal Word: Class:
Precautionary Statements: UN#:
Hazard Statements: Packing Group:

Application In Synthesis of [ 679405-85-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 679405-85-7 ]

[ 679405-85-7 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 372118-01-9 ]
  • [ 124-41-4 ]
  • [ 679405-85-7 ]
YieldReaction ConditionsOperation in experiment
In tetrahydrofuran; methanol; at 0 - 20℃; Step 4.Preparation of 6-chloro-4-methoxy-pyridazine-3-carboxylic acid methyl ester 6 sodium methoxide (25 wt % I methanol, 1.1 ML) is added to a stirred solution of <strong>[372118-01-9]4,6-dichloro-pyridazine-3-carboxylic acid methyl ester</strong> (1.03 g, 5 mmol) in THF (25 ML) cooled to 0 C. The reaction mixture is stirred at room temperature overnight and then poured into 1N HCl (8 ML).The resulting solution is then neutralized by saturated NaHCO3. EtOAc (20 ML) is added and the layers are separated.The aqueous layer is extracted twice with EtOAc (20 ML) and the combined extracts are washed with brine (25 ML), dried (Na2SO4) and evaporated.The residue is then purified by flash column chromatography (silica gel, eluted with 2:1 hexane:EtOAc) to give 6-chloro-4-methoxy-pyridazine-3-carboxylic acid methyl ester as a white solid.
Reference： [1]Patent: US2004/77653,2004,A1 .Location in patent: Page 18
  • 2
  • [ 372118-00-8 ]
  • [ 679405-85-7 ]
Reference： [1]Patent: US2004/77653,2004,A1
  • 3
  • [ 67-56-1 ]
  • [ 372118-01-9 ]
  • [ 124-41-4 ]
  • [ 679405-85-7 ]
YieldReaction ConditionsOperation in experiment
In tetrahydrofuran; at 0 - 20℃; To a soln. of <strong>[372118-01-9]methyl 4,6-dichloropyridazine-3-carboxylate</strong> (550 mg, 2.66 mmol) in anh. THF (13 mL) was added dropwise at 0C a 25% soln. of NaOMe in MeOH (0.638 mL, 2.79 mmol). The rxn mixture was stirred ON at RT and poured onto a 1 M aq. soln. of HCI. The soln. was neutralized with a sat. aq. soln. of NaHC03 and extracted with EtOAc (3x). The combined org. phases were washed with brine, dried over MgS04 and concentrated in vacuo. The crude was purified by CC using Hept/EtOAc. LC-MS: tR=0.54 min, [M+H]+: 203.14
Reference： [1]Patent: WO2019/141803,2019,A1 .Location in patent: Page/Page column 82

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