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Chemical Structure| 680591-10-0 Chemical Structure| 680591-10-0

Structure of 680591-10-0

Chemical Structure| 680591-10-0

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Product Details of [ 680591-10-0 ]

CAS No. :680591-10-0
Formula : C7H10N2S
M.W : 154.23
SMILES Code : SC1=CC=C(N(C)C)N=C1

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Application In Synthesis of [ 680591-10-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 680591-10-0 ]

[ 680591-10-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 26163-07-5 ]
  • [ 680591-10-0 ]
YieldReaction ConditionsOperation in experiment
21% With n-butyllithium; sulfur; In tetrahydrofuran; hexane; at -78℃; for 0.433333h; [AT-78C] a solution of [(5-BROMO-PYRIDIN-2-YL)-DIMETHYL-AMINE] (15.0 mmol) in THF (50 mL) was added dropwise to a solution of n-BuLi in Hexane (1.6 [MOVL,] 10.0 mL). The reaction mixture was stirred for 15 min and sulfur (20.0 mmol) was added. After 1 min a solution of n-BuLi in Hexane (1.6 mol/L, 20.0 ml) was added. The reaction mixture was stirred for 10 min at-78C and purified immediately by flash-chromatography (ethyl acetate/heptane 1: 3) without previous work-up. A second flash-chromatography (gradient: ethyl [ACETATE/HEPTANE] 1: 19 to 1: 9) yielded 0.50 g (3.24 mmol, 21%) of 6-dimethylamino-pyridine-3-thiol as a yellow oil. LC-MS: rt = 0.46 min, 155 [(M+1,] ES+).
 

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