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Chemical Structure| 681278-32-0 Chemical Structure| 681278-32-0

Structure of 681278-32-0

Chemical Structure| 681278-32-0

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Product Details of [ 681278-32-0 ]

CAS No. :681278-32-0
Formula : C11H10N2O2
M.W : 202.21
SMILES Code : COC1=NC2=C(C3OC3)C=CN=C2C=C1

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Application In Synthesis of [ 681278-32-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 681278-32-0 ]

[ 681278-32-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 681278-32-0 ]
  • [ 287114-25-4 ]
  • [ 877457-34-6 ]
YieldReaction ConditionsOperation in experiment
With lithium perchlorate; potassium carbonate; In N,N-dimethyl-formamide; at 80℃; 8h) {8-[2-Hydroxy-2-(6-methoxy-[1,5]-naphthyridin-4-yl)-ethyl]-8-aza-bicyclo[3.2.1]oct-3-yl}-carbamic acid tert-butyl ester(enantiomer 1)2-Methoxy-8-oxiranyl-[1,5]-naphthyridine (If) (726 mg) and amine(8g) (813 mg) were dissolved in DMF (9 ml), treated withpotassium carbonate (521 mg) and lithium perchlorate (382 mg)and stirred at 80C over night. The mixture was concentrated,dissolved in dichloromethane/methanol 9:1 and washed with water.The organic layer was dried over magnesium sulfate, filtered andconcentrated. The residue was purified by flash chromatography(silica gel, dichloromethane/methanol 97:3) to give the desiredproduct (1.28 g).XH NMR (300MHz, d6-DMSO) : 5: 8.78 (d, 1H) , 8.26 (d, 1H) , 7.78(d, 1H), 7.28 (d, 1H), 6.69 (bs, 1H), 5.52 (bs, 1H), 4.03 (s,3H) , 3.65-3.52 (m, 2H) , 3.40-3.28 (m, 2H), 1.98-1.80 (m, 2H),1.72-1.43 (m, 6H) , 1.39-1.28 (m, 2H), 1.35 (s, 9H)
 

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