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                            The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
 
                
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    							Batch number can be found on the product's label following the word 'Batch'.
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| CAS No. : | 681808-26-4 | 
| Formula : | C8H15NO4S | 
| M.W : | 221.27 | 
| SMILES Code : | O=C(OC(C)(C)C)NS(=O)(C1CC1)=O | 
| MDL No. : | MFCD16660018 | 
| GHS Pictogram: |   | 
| Signal Word: | Warning | 
| Hazard Statements: | H302 | 
| Precautionary Statements: | P264-P270-P301+P312-P330-P501 | 
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

| Yield | Reaction Conditions | Operation in experiment | 
|---|---|---|
| 99% | Stage lc:oI IBocHN-SI Io[0182] Cyclopropanesulfonamide (5.0 g, 41.26 mmol, 1.0 eq.), triethylamine (8.62 g, 61.90 mmol, 1.5 eq.) and dichloromethane (50 mL) were charged in a 100 mL round bottom flask. Di-te/t-butyldicarbonate (10.8 g, 49.52 mmol, 1.2 eq.) and N,N- dimethylaminopyridine (252 mg, 2.06 mmol, 0.05 eq.) were added portion wise and the reaction mixture stirred at ambient temperature for 48 hours. The solvent was removed in vacuo and the residue diluted with water (20 mL). The aqueous phase was acidified to pH = 1 with 1M hydrochloric acid, and extracted with ethyl acetate (3 x 100 mL). The organic extracts were combined, washed with water (100 mL) and brine (100 mL), dried over magnesium sulfate, filtered and the solvent removed in vacuo to give 9.1 g (99% yield) of the title compound as a white solid. 1H NMR (500 MHz, CDC13) δ ppm 7.14 (br. s., 1 H) 2.90 (tt, 7=8.09, 4.73 Hz, 1 H) 1.50 - 1.54 (m, 9 H) 1.35 - 1.40 (m, 2 H) 1.09 - 1.15 (m, 2 H). LC-MS: purity 100% (UV), tR 1.62 min m/z [M+Na]+ 243.95 (MET/CR/1278). | |
| 96% | With dmap; triethylamine; In dichloromethane; at 20℃;Cooling with ice; | To an iced slurry of <strong>[154350-29-5]cyclopropanesulfonamide</strong> (1.21 g, 9.99 mmol), Triethylamine (2.95 mL, 20.97 mmol), and 4-Dimethylaminopyridine (0.061 g, 0.499 mmol) in CH2Cl2 (50 mL) was added solution of Di-tert-butyl dicarbonate (2.423 mL, 10.99 mmol) in DCM (10 mL) dropwise. The formed solution was stirred at room temperature overnight, Removed the solvent in vacuo. The residual oil was taken up in EtOAc and washed with 1M HCl and brine. Dried over MgSO4, filtered, and concentrated. The residue was purified by Biotage column, eluted with gradient 5%50% acetone-hexane to yield the desired produce tert-butyl cyclopropylsulfonylcarbamate (2.17 g, 9.61 mmol, 96% yield) as a viscous oil, which solidified upon standing on bench. 1H NMR (400 MHz, CDCl3) ppm 1.11-1.13 (m, 2H) 1.37-1.39 9m, 2H) 1.53 (s, 9H), 2.89-2.92 (m, 1H) 7.00-7.05 (b, NH). | 
| 94% | With dmap; triethylamine; In dichloromethane; at 20℃; | Step 4:; To the solid <strong>[154350-29-5]cyclopropanesulfonamide</strong> 2d4 (1.51 g ; 12.46 mmol) was added insequence: di-t-butyl-dicarbonate (3.26 g ; 14.95 mmol) dissolved in anhydrousdichloromethane (15 ml_), triethylamine (2.6 ml; 18.65 mmol) anddimethylaminopyridine (76 mg; 0.622 mmol). The resulting solution was stirred atroom temperature overnight and subsequently evaporated to near dryness. Theresidue was diluted with EtOAc, washed with 1N aq. HCI (3x) and brine (1x), dried(MgSO4), filtered and evaporated to dryness to provide the Boc-<strong>[154350-29-5]cyclopropylsulfonamide</strong> product 2d5 as a white solid (2.6 g ; 94%). | 
| 94% | With dmap; triethylamine; In dichloromethane; at 20℃; | To the solid <strong>[154350-29-5]cyclopropanesulfonamide</strong> 2d4 (1.51 g; 12.46 mmol) was added in sequence: di-t-butyl-dicarbonate (3.26 g; 14.95 mmol) dissolved in anhydrous dichloromethane (15 mL), triethylamine (2.6 mL; 18.65 mmol) and dimethylaminopyridine (76 mg; 0.622 mmol). The resulting solution was stirred at room temperature overnight and subsequently evaporated to near dryness. The residue was diluted with EtOAc, washed with 1 N aq. HCl (3×) and brine (1×), dried (MgSO4), filtered and evaporated to dryness to provide the Boc-<strong>[154350-29-5]cyclopropylsulfonamide</strong> product 2d5 as a white solid (2.6 g; 94%). | 
| 94% | With dmap; triethylamine; In dichloromethane; at 18 - 22℃; | Step D; To the solid <strong>[154350-29-5]cyclopropanesulfonamide</strong> 4A4 (1.51 g ; 12.46 mmol) was added in sequence: di-t-butyl-dicarbonate (3.26 g ; 14.95 mmol) dissolved in anhydrous dichloromethane (15 mL), triethylamine (2.6 mL; 18.65 mmol) and dimethylaminopyridine (76 mg; 0.622 mmol). The resulting solution was stirred at room temperature overnight and subsequently evaporated to near dryness. The residue was diluted with EtOAc, washed with 1 N aq. HCI (3x) and brine (1x), dried EPO <DP n="44"/>(MgSO4), filtered and evaporated to dryness to provide the Boc- <strong>[154350-29-5]cyclopropylsulfonamide</strong> product 4A5 as a white solid (2.6 g ; 94%). | 
| 93% | With dmap; triethylamine; In dichloromethane; for 5.08333h; | Compound 2 (4g, 33 mmol) was suspended in dry DCM (100 mL) containing Et3N (5 mL, 36.3 mmol) and DMAP (0.4g , 3.3 mmol). A solution of (Boc)20 (8.3g, 38 mmol) in dry DCM (50 mL) was added dropwise with stirring over 5 min. after 5h, the solution was concentrated in vacuo and the residue treated with EtOAc (30OmL) and IN HCl. The EtOAc layer was washed successively with water (40 mLl) and brine (40 mL), dried (Na2SO4), and concentrated to leave a solid. Heating with hexane (30 mL), cooling to room temperature, and filtration provide compound 3 as a white solid 6.8 g (yield 93%). | 
| 88% | With dmap; triethylamine; In dichloromethane; | To a solution of <strong>[154350-29-5]cyclopropanesulfonamide</strong> (6 g, 50 mmol) in DCM (50 ml) were added triethylamine (7.5 ml, 74 mmol) followed by DMAP (0.3 g, 7.5 mmol) and di-tert-butyl dicarbonate (13 g, 59 ml) and the reaction was left stirring overnight. The solvent was removed; water, 2N HCl (40 ml) and ethyl acetate were added. The organic layer was washed with brine, dried over magnesium sulfate and evaporated to give Boc-<strong>[154350-29-5]cyclopropanesulfonamide</strong> as a white solid, used on the next step without further purification. Yield 9.73 g (88%). | 
| 87% | With dmap; triethylamine; In dichloromethane; at 0 - 20℃; for 3.5h; | Step 1: Preparation of Boc-cyclopropane sulfonyl amide 50. To a solution of <strong>[154350-29-5]cyclopropanesulfonamide</strong>, TEA (13.9 mL), and DMAP (1.11 g, 0.1 eq.) (10.72 g, leq.) in DCM (160 mL) was added a solution of BoC2O (21.88 g, 0.8 eq.) in DCM (10OmL) was added dropwise at 0 0C over 30 min. The mixture was then allowed to warm up to room temperature and stirred for 3 hrs. The solution was washed with IN HCl, water and brine, dried over Na2SO4, filtered, and concentrated under reduced pressure to yield after trituration in hexane compound 50 as a white solid in 87% yield.1H NMR (CDCl3, 400 MHz): δ 0.92-0.96 (td, J = 6.5 and 1.50 Hz, 2H), 1.51 (s, 9H), 1.60- 1.64 (td, 7 = 6.46 and 1.50 Hz, 2H), 1.25 (m, IH), 6.99 (brs, IH). | 
| 85% | With dmap; triethylamine; In dichloromethane; at 20℃;Product distribution / selectivity; | C.5) Alternative Preparation of Cyclopropylsulfonylamine tert-butyl carbamate To a solution of <strong>[154350-29-5]cyclopropylsulfonamide</strong> (6.0 g, 50.0 mmol) in CH2Cl2 (50 mL) was added BOC2O (13.0 g, 59.0 mmol), triethylamine (7.5 mL, 74 mmol), and 4-DMAP (0.30 g, 2.5 mmol). The reaction mixture was stirred overnight at room temperature, diluted with ethyl acetate (300 mL), partitioned with 1 N HCl (3*100 mL), dried over MgSO4, filtered, and concentrated in vacuo to provide 9.3 g (85%) of cyclopropylsulfonylamine tert-butylcarbamate. | 
| 85% | With dmap; triethylamine; In dichloromethane; at 20℃;Product distribution / selectivity; | Step ii) To a solution of <strong>[154350-29-5]cyclopropylsulfonamide</strong> (6.0 g, 50.0 mmol) in CH2Cl2 (50 mL) was added BOC2O(13.0 g, 59.0 mmol), Et3N (7.5 mL, 74 mmol), and 4-DMAP (0.30 g, 2.5 mmol). The reaction mixture was stirred overnite at rt, diluted with EtOAc (300 mL), partitioned with 1 N HCl (3*100 mL), dried over MgSO4 and concentrated in vacuo to afford 9.3 g (85%) of cyclopropylsulfonylamine tert-butylcarbamate as a white solid having identical data to its preparation in Step IIc. | 
| With dmap; triethylamine; In dichloromethane; at 0 - 20℃; | Step a: tert-butyl (cyciopropyisuifonyi)carbamate To a mixture of 15 g (124 mmof) cyclopropanβsulfo nic acid amide, 25.9 mL (186 mmol) triethylamine and 0.8 g (6.2 mmol) DMAP in 150 ml DCM was added 32.4 g (149 mmol) Boc- anhydride at OC. The mixture was slowly warmed to RT and stirred for 48 h. After dilution with DCM the mixture was washed with 1 N aq. HCi solution. The organic layer was dried over Na2SO4 and concentrated in vacuo to yield the title compound which was used in the next step without further purification. LC-MS (method E): Rt = 1.254 min; MIz = 220.2 [M-H]. | |
| 2.66 g | With dmap; triethylamine; In dichloromethane; for 16h; | N-tert-Butyloxycarbonyl<strong>[154350-29-5]cyclopropanesulfonamide</strong> 1.46 g of <strong>[154350-29-5]cyclopropanesulfonamide</strong> were initially charged in a mixture of 30 ml of dichloromethane and 1.67 ml of triethylamine, and then 2.63 g of di-tert-butyl dicarbonate and 0.15 g of 4-dimethylaminopyridine were added and the mixture was stirred for 16 hours. The reaction solution was washed with 1 N aqueous hydrochloric acid, saturated aqueous sodium chloride solution and water, and the organic phase was dried over Na2SO4 and concentrated by rotary evaporation. This gave the product (2.66 g) with a molecular weight of 221.3 g/mol (C8H15NO4S); MS (ESI): m/e=166 (M-tert-Butyl+H+). | 
| 2.66 g | With dmap; triethylamine; In dichloromethane; for 16h; | N-tert-Butyloxycarbonyl<strong>[154350-29-5]cyclopropanesulfonamide</strong> 1.46 g of <strong>[154350-29-5]cyclopropanesulfonamide</strong> were initially charged in a mixture of 30 ml of dichloromethane and 1.67 ml of triethylamine, and then 2.63 g of di-tert-butyl dicarbonate and 0.15 g of 4-dimethylaminopyridine were added and the mixture was stirred for 16 hours. The reaction solution was washed with 1 N aqueous hydrochloric acid, saturated aqueous sodium chloride solution and water, and the organic phase was dried over Na2SO4 and concentrated by rotary evaporation. This gave the product (2.66 g) with a molecular weight of 221.3 g/mol (C8H15NO4S); MS (EST): m/e=166 (M-tert-Butyl+H+). | 
| 2.66 g | With dmap; triethylamine; In dichloromethane; for 16h; | 1.46 g of <strong>[154350-29-5]cyclopropanesulfonamide</strong> were initially charged in a mixture of 30 ml of dichloromethane and 1.67 ml of triethylamine, and then 2.63 g of di-tert-butyl dicarbonate and 0.15 g of 4-dimethylaminopyridine were added and the mixture was stirred for 16 hours. The reaction solution was washed with 1 N aqueous hydrochloric acid, saturated aqueous sodium chloride solution and water, and the organic phase was dried over Na2SO4 and concentrated by rotary evaporation. This gave the product (2.66 g) with a molecular weight of 221.3 g/mol (C8H15NO4S); MS (ESI): m/e=166 (M-tert-butyl+H+). | 
| With dmap; triethylamine; In dichloromethane; at 0 - 25℃; | Step 2: Preparation of tert-butyl cyclopropylsulfonylcarbamate: To a solution of A3 (2.0 g, 16.5 mmol) in DCM (30 mL) at 0 C was added DMAP (0.1 g, 0.825 mmol), Et3N (3.52 mL, 24.7 mmol) and Boc20 (4.32 g, 19.8 mmol). The reaction mixture was allowed to warm to RT and stir overnight. After that time, the volatiles were removed under reduced pressure. To the crude residue was added water. The aqueous phase was acidified to pH= 1 with the addition of aqueous 1.0 N HC1 and the mixture was extracted with EtOAc. The combined organic layers were washed with water and brine, then dried over Na2S04, filtered and concentrated to yield compound A4. NMR (CDC13, 300 MHz): δ 7.20 (bs, 1H), 2.92 - 2.86 (m, 1H), 1.55 (s, 9H), 1.39 - 1.35 (m, 2H), 1.28 - 1.24 (m, 2H). | |
| With dmap; triethylamine; In dichloromethane; at 0 - 20℃; for 4h; | To a solution of <strong>[154350-29-5]cyclopropanesulfonamide</strong> (100 g, 82.6 mmol) in DCM (800 ml) was added triethylamine (234 ml, 165 mmol) followed by DMAP (10.28 g, 82.6 mmol) at 0 C. under nitrogen. To this reaction mixture Boc anhydride (247 ml, 107 mmol) in DCM (400 ml) was added slowly. The resulting mixture was stirred for 4 h at room temperature. The reaction mixture was diluted with water and extracted with ethyl acetate. The combine organic layer was washed with 1.5 N HCl solution and 10% NaHCO3and dried over anhydrous sodium sulfate, filtered and evaporated under reduced pressure to get crude compound (143 g, 65.0%) as solid. The crude compound was directly taken for the next step.1H NMR (400 MHz, DMSO-d6): δ ppm 11.08 (s, 1H), 2.90 (m, 1H), 1.48 (s, 9H), 1.06 (m, 4H). | |
| With dmap; triethylamine; In dichloromethane; at 0 - 20℃; for 4h;Inert atmosphere; | To a solution of <strong>[154350-29-5]cyclopropanesulfonamide</strong> (100 g, 82.6 mmol) in DCM (800 ml) was added triethylamine (234 ml, 165 mmol) followed by DMAP (10.28 g, 82.6 mmol) at 0 C. under nitrogen. To this reaction mixture Boc anhydride (247 ml, 107 mmol) in DCM (400 ml) was added slowly. The resulting mixture was stirred for 4 h at room temperature. The reaction mixture was diluted with water and extracted with ethyl acetate. The combine organic layer was washed with 1.5 N HCl solution and 10% NaHCO3 and dried over anhydrous sodium sulfate, filtered and evaporated under reduced pressure to get crude compound (143 g, 65%) as a solid. The crude compound was directly taken for the next step. 1H NMR (400 MHz, DMSO-d6): δ ppm 11.08 (s, 1H), 2.90 (m, 1H), 1.48 (s, 9H), 1.06 (m, 4H). | |
| 65% (143 g) | With dmap; triethylamine; In dichloromethane; at 0 - 20℃; for 4h; | Step 1: Preparation of tert-butyl cyclopropylsulfonylcarbamate To a solution of <strong>[154350-29-5]cyclopropanesulfonamide</strong> (100 g, 82.6 mmol) in DCM (800 ml) was added triethylamine (234 ml, 165 mmol) followed by DMAP (10.28 g, 82.6 mmol) at 0 C. under nitrogen. To this reaction mixture Boc anhydride (247 ml, 107 mmol) in DCM (400 ml) was added slowly. The resulting mixture was stirred for 4 h at room temperature. The reaction mixture was diluted with water and extracted with ethyl acetate. The combine organic layer was washed with 1.5 N HCl solution and 10% NaHCO3 and dried over anhydrous sodium sulfate, filtered and evaporated under reduced pressure to get crude compound (143 g, 65.0%) as solid. The crude compound was directly taken for the next step. 1H NMR (400 MHz, DMSO-d6): δ ppm 11.08 (s, 1H), 2.90 (m, 1H), 1.48 (s, 9H), 1.06 (m, 4H). | 
| With dmap; triethylamine; In dichloromethane; at 0 - 20℃; for 12h; | To a solution of <strong>[154350-29-5]cyclopropanesulfonamide</strong> (100 g, 825 mmol) in DCM (1 L) at 0 C was sequentially added DMAP (5.0 g, 41.3 mmol), TEA (173 mL, 1238 mmol), and Boc-anhydride (216 g, 813 mmol). The reaction mixture was allowed to warm to RT and stirred for 12 h. After the completion of reaction (monitored by TLC), it was concentrated under reduced pressure. The crude residue was taken in EtOAc (2000 mL) and washed with aqueous 1.5 _ HC1 (2 x 1000 mL). The organic layer was washed with water (1000 mL), brine (1000 mL) and dried over Na2SO4. The organic layer was concentrated under reduced pressure to afford 22a (180 g, 99%) as a transparent liquid, which was used in next step without purification. MS (ESI -ve ion) m/z: [M-1] = 220.2.1H NMR (400 MHz, chloroform-d) ^ 7.36 (s, 1H), 2.93- 2.88 (m, 1H), 1.53 (d, J = 0.6 Hz, 9H), 1.39-1.36 (m, 2H), 1.15-1.10 (m, 2H). | 

Tags: 681808-26-4 synthesis path| 681808-26-4 SDS| 681808-26-4 COA| 681808-26-4 purity| 681808-26-4 application| 681808-26-4 NMR| 681808-26-4 COA| 681808-26-4 structure
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| P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. | 
| P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. | 
| P308 + P313 | IF exposed or concerned: Get medical advice/attention. | 
| P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. | 
| P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. | 
| P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. | 
| P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. | 
| P337 + P313 | IF eye irritation persists: Get medical advice/attention. | 
| P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. | 
| P370 + P376 | In case of fire: Stop leak if safe to Do so. | 
| P370 + P378 | In case of fire: | 
| P370 + P380 | In case of fire: Evacuate area. | 
| P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. | 
| P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. | 
| Storage | |
| Code | Phrase | 
| P401 | |
| P402 | Store in a dry place. | 
| P403 | Store in a well-ventilated place. | 
| P404 | Store in a closed container. | 
| P405 | Store locked up. | 
| P406 | Store in corrosive resistant/ container with a resistant inner liner. | 
| P407 | Maintain air gap between stacks/pallets. | 
| P410 | Protect from sunlight. | 
| P411 | |
| P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. | 
| P413 | |
| P420 | Store away from other materials. | 
| P422 | |
| P402 + P404 | Store in a dry place. Store in a closed container. | 
| P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. | 
| P403 + P235 | Store in a well-ventilated place. Keep cool. | 
| P410 + P403 | Protect from sunlight. Store in a well-ventilated place. | 
| P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. | 
| P411 + P235 | Keep cool. | 
| Disposal | |
| Code | Phrase | 
| P501 | Dispose of contents/container to ... | 
| P502 | Refer to manufacturer/supplier for information on recovery/recycling | 
| Physical hazards | |
| Code | Phrase | 
| H200 | Unstable explosive | 
| H201 | Explosive; mass explosion hazard | 
| H202 | Explosive; severe projection hazard | 
| H203 | Explosive; fire, blast or projection hazard | 
| H204 | Fire or projection hazard | 
| H205 | May mass explode in fire | 
| H220 | Extremely flammable gas | 
| H221 | Flammable gas | 
| H222 | Extremely flammable aerosol | 
| H223 | Flammable aerosol | 
| H224 | Extremely flammable liquid and vapour | 
| H225 | Highly flammable liquid and vapour | 
| H226 | Flammable liquid and vapour | 
| H227 | Combustible liquid | 
| H228 | Flammable solid | 
| H229 | Pressurized container: may burst if heated | 
| H230 | May react explosively even in the absence of air | 
| H231 | May react explosively even in the absence of air at elevated pressure and/or temperature | 
| H240 | Heating may cause an explosion | 
| H241 | Heating may cause a fire or explosion | 
| H242 | Heating may cause a fire | 
| H250 | Catches fire spontaneously if exposed to air | 
| H251 | Self-heating; may catch fire | 
| H252 | Self-heating in large quantities; may catch fire | 
| H260 | In contact with water releases flammable gases which may ignite spontaneously | 
| H261 | In contact with water releases flammable gas | 
| H270 | May cause or intensify fire; oxidizer | 
| H271 | May cause fire or explosion; strong oxidizer | 
| H272 | May intensify fire; oxidizer | 
| H280 | Contains gas under pressure; may explode if heated | 
| H281 | Contains refrigerated gas; may cause cryogenic burns or injury | 
| H290 | May be corrosive to metals | 
| Health hazards | |
| Code | Phrase | 
| H300 | Fatal if swallowed | 
| H301 | Toxic if swallowed | 
| H302 | Harmful if swallowed | 
| H303 | May be harmful if swallowed | 
| H304 | May be fatal if swallowed and enters airways | 
| H305 | May be harmful if swallowed and enters airways | 
| H310 | Fatal in contact with skin | 
| H311 | Toxic in contact with skin | 
| H312 | Harmful in contact with skin | 
| H313 | May be harmful in contact with skin | 
| H314 | Causes severe skin burns and eye damage | 
| H315 | Causes skin irritation | 
| H316 | Causes mild skin irritation | 
| H317 | May cause an allergic skin reaction | 
| H318 | Causes serious eye damage | 
| H319 | Causes serious eye irritation | 
| H320 | Causes eye irritation | 
| H330 | Fatal if inhaled | 
| H331 | Toxic if inhaled | 
| H332 | Harmful if inhaled | 
| H333 | May be harmful if inhaled | 
| H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled | 
| H335 | May cause respiratory irritation | 
| H336 | May cause drowsiness or dizziness | 
| H340 | May cause genetic defects | 
| H341 | Suspected of causing genetic defects | 
| H350 | May cause cancer | 
| H351 | Suspected of causing cancer | 
| H360 | May damage fertility or the unborn child | 
| H361 | Suspected of damaging fertility or the unborn child | 
| H361d | Suspected of damaging the unborn child | 
| H362 | May cause harm to breast-fed children | 
| H370 | Causes damage to organs | 
| H371 | May cause damage to organs | 
| H372 | Causes damage to organs through prolonged or repeated exposure | 
| H373 | May cause damage to organs through prolonged or repeated exposure | 
| Environmental hazards | |
| Code | Phrase | 
| H400 | Very toxic to aquatic life | 
| H401 | Toxic to aquatic life | 
| H402 | Harmful to aquatic life | 
| H410 | Very toxic to aquatic life with long-lasting effects | 
| H411 | Toxic to aquatic life with long-lasting effects | 
| H412 | Harmful to aquatic life with long-lasting effects | 
| H413 | May cause long-lasting harmful effects to aquatic life | 
| H420 | Harms public health and the environment by destroying ozone in the upper atmosphere | 
Sorry,this product has been discontinued.
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