[ CAS No. 6826-24-0 ] {[proInfo.proName]}

Name: 6826-24-0|5-Phenyloxazol-2-amine|96%
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Quality Control of [ 6826-24-0 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 6826-24-0 ]

SDS Specification

Alternatived Products of [ 6826-24-0 ]

Product Details of [ 6826-24-0 ]

CAS No. :	6826-24-0	MDL No. :	MFCD00087876
Formula :	C₉H₈N₂O	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	IUHYFLKPKSFRCT-UHFFFAOYSA-N
M.W :	160.17	Pubchem ID :	12707563
Synonyms :

Calculated chemistry of [ 6826-24-0 ] Expand+

Physicochemical Properties

Num. heavy atoms :	12
Num. arom. heavy atoms :	11
Fraction Csp3 :	0.0
Num. rotatable bonds :	1
Num. H-bond acceptors :	2.0
Num. H-bond donors :	1.0
Molar Refractivity :	46.34
TPSA :	52.05 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.11 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.63
Log Po/w (XLOGP3) :	1.65
Log Po/w (WLOGP) :	1.93
Log Po/w (MLOGP) :	0.85
Log Po/w (SILICOS-IT) :	1.73
Consensus Log Po/w :	1.56

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.48
Solubility :	0.524 mg/ml ; 0.00327 mol/l
Class :	Soluble
Log S (Ali) :	-2.36
Solubility :	0.705 mg/ml ; 0.0044 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-3.38
Solubility :	0.066 mg/ml ; 0.000412 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.34

Safety of [ 6826-24-0 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P280-P301+P312-P302+P352-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 6826-24-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 6826-24-0 ]

[ 6826-24-0 ] Synthesis Path-Downstream 1~26

1
[ 6826-24-0 ]
[ 121-60-8 ]
[ 860542-40-1 ]

Reference： [1]Dansk Tidsskrift for Farmaci,1942,vol. 16,p. 1,8

2
[ 2208-89-1 ]
[ 70-11-1 ]
[ 6826-24-0 ]

Reference： [1]Chemische Berichte,1966,vol. 99,p. 2110,2117
[2]Chemische Berichte,1966,vol. 99,p. 2110 - 2117

3
[ 156-62-7 ]
[ 70-11-1 ]
[ 6826-24-0 ]

Reference： [1]Recueil des Travaux Chimiques des Pays-Bas,1942,vol. 61,p. 463,465

4
[ 6826-24-0 ]
[ 504-64-3 ]
[ 1672-10-2 ]

Reference： [1]Journal of general chemistry of the USSR,1964,vol. 34,p. 3470 - 3471
Zhurnal Obshchei Khimii,1964,vol. 34,p. 3427 - 3429

5
[ 6826-24-0 ]
[ 108-24-7 ]
[ 6826-25-1 ]

Reference： [1]Chemische Berichte,1966,vol. 99,p. 2110 - 2117

6
[ 6826-24-0 ]
[ 96887-92-2 ]
[ 140685-76-3 ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1992,vol. 40,p. 245 - 248

7
[ 6826-24-0 ]
[ 103-71-9 ]
[ 90831-46-2 ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1984,vol. 32,p. 1032 - 1039

8
[ 6826-24-0 ]
[ 103-71-9 ]
2,6-diphenyl-5H-oxazolo<3,2-a><1,3,5>tirazine-5,7(6H)-dione [ No CAS ]

Reference： [1]Chemical and pharmaceutical bulletin,1982,vol. 30,p. 4195 - 4198

9
[ 6826-24-0 ]
[ 624-83-9 ]
[ 90831-45-1 ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1984,vol. 32,p. 1032 - 1039

10
[ 6826-24-0 ]
(2S,5R)-5-Phenyl-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester [ No CAS ]
(2S,5R)-5-Phenyl-2-(5-phenyl-oxazol-2-ylcarbamoyl)-piperidine-1-carboxylic acid tert-butyl ester [ No CAS ]

Reference： [1]Tetrahedron Letters,1993,vol. 34,p. 7685 - 7688

11
[ 76758-07-1 ]
[ 6826-24-0 ]

Reference： [1]Journal of Organic Chemistry,1981,vol. 46,p. 2069 - 2072
[2]Heterocycles,2004,vol. 64,p. 347 - 355

12
[ 6826-24-0 ]
[ 119072-55-8 ]
[ 100-52-7 ]
tert-Butyl-(2,6-diphenyl-imidazo[2,1-b]oxazol-5-yl)-amine [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,1998,vol. 37,p. 2234 - 2237

15
[ 70-11-1 ]
monosodium-cyanamide [ No CAS ]
[ 6826-24-0 ]

Reference： [1]Recueil des Travaux Chimiques des Pays-Bas,1942,vol. 61,p. 463,465

16
2-phenyloxazolo[3,2-a]pyrimidinium perchlorate [ No CAS ]
[ 6826-24-0 ]

Reference： [1]Synthesis,2007,p. 263 - 270

17
[ 933053-16-8 ]
[ 6826-24-0 ]

Reference： [1]Synthesis,2007,p. 263 - 270

18
[ 70-11-1 ]
CS₂ [ No CAS ]
[ 6826-24-0 ]

Reference： [1]Synthesis,2007,p. 263 - 270

19
[ 6826-24-0 ]
sulfanilic acid-(5-phenyl-oxazol-2-ylamide) [ No CAS ]

Reference： [1]Dansk Tidsskrift for Farmaci,1942,vol. 16,p. 1,8

20
[ 420-04-2 ]
[ 582-24-1 ]
[ 6826-24-0 ]

Yield	Reaction Conditions	Operation in experiment
21%	In ethanol;Inert atmosphere; Reflux;	Step 1: To a solution of 2-hydroxyacetophenone (1.0 g, 7.4 mmol) in ethanol (20 mL) was added cyanamide (400 mg, 9.4 mmol) and the reaction mixture was heated at reflux under nitrogen overnight. The reaction mixture was poured into aqueous 6N HCl (40 mL) and washed with ethyl acetate and ethyl acetate layer discarded. The aqueous layer was made alkaline with aqueous NaOH and extracted 3 times with ethyl acetate. The combined organic phase was dried over Na2SO4 and concentrated in vacuo to afford 5-phenyl-oxazol-2-ylamine (250 mg, 21%):

Reference： [1]Patent: US2012/149718,2012,A1 .Location in patent: Page/Page column 45

21
[ 122-78-1 ]
[ 6826-24-0 ]

Reference： [1]Patent: WO2015/138895,2015,A1

22
[ 16927-13-2 ]
[ 57-13-6 ]
[ 6826-24-0 ]

Yield	Reaction Conditions	Operation in experiment
200 mg	In ethanol; at 20 - 80℃; for 6.0h;Inert atmosphere;	[000318] Synthesis of 5-phenyloxazol-2-amine (396): To a stirred solution of compound 394 (800 mg, crude) in EtOH (10 mL) under inert atmosphere was added urea 395 (482 mg, 8.04 mmol) at RT; heated at 80 C and stirred for 6 h. The reaction was monitored by TLC; after completion of the reaction, the volatiles were removed in vacuo and the residue was diluted with water (60 mL). The pH was neutralized with 10% aqueous NaHCO3 solution (10 mL) and extracted with EtOAc (2 x 100 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo to obtain the crude. The crude was purified through flash column chromatography using 2-3% MeOH/ CH2C12 to afford compound 396 (200 mg, 32%) as an off-white solid. TLC: 5% MeOH/ CH2C12 (Rj: 0.5); 1H NMR (400 MHz, DMSOd 6): oe 7.45 (d, J 7.2 Hz, 2H), 7.36 (t, J 7.8 Hz, 2H), 7.21-7.16 (m, 2H), 6.81 (s, 2H);

Reference： [1]Patent: WO2015/138895,2015,A1 .Location in patent: Paragraph 000318

23
[ 6826-24-0 ]
[ 935433-74-2 ]
C₂₃H₁₄FN₃O₃S [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With 4-methyl-morpholine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; at 0 - 20℃; for 16.0h;Inert atmosphere;	[000216] To a stirred solution of compound 35 (50 mg, 0.17 mmol) in CH2C12 (5 mL) under argon atmosphere were added ethyl 2-amino-2-(pyridin-2-yl) acetate hydrochloride 249 (26 mg, 0.17 mmol), propylphosphonic anhydride (50% solution in EtOAc, 0.22 mL, 0.34 mmol), NMM (0.037 mL, 0.34 mmol) at 0 C; warmed to RT and stirred for 16 h. The reaction was monitored by TLC; after completion of the reaction, the volatiles were removed in vacuo and diluted with water (20 mL) or the pH of the reaction mixture was adjusted to 8 and extracted with CH2C12 (2 x 30 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo to obtain the crude. The crude was purified either through silica gel column chromatography or triturated to afford the desired product.

Reference： [1]Patent: WO2015/138895,2015,A1 .Location in patent: Paragraph 000216; 000347

24
[ 6826-24-0 ]
4-nitrophenyl 4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenethylcarbamate [ No CAS ]
1-(5-phenyloxazol-2-yl)-3-(4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenethyl)urea [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
18%	With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 5.0h;Reflux;	To a solution of 4-nitrophenyl 4-( l-(4-(trifluoromethoxy)phenyl)- ltf-l,2,4-triazol-3-yl)phenethylcarbamate (C33) (0.174 g, 0.340 mmol) in tetrahydrofuran (3.4 mL) was added <strong>[6826-24-0]5-phenyloxazol-2-amine</strong> (0.0570 g, 0.360 mmole) and diisopropylethylamine (0.120 mL, 0.689 mmol). The mixture was refluxed for 5 hours. After cooling, the solution was diluted with methanol (5 mL) and adsorbed onto Celite. Purification by flash column chromatography using 0-100% ethyl acetate/(l : l hexanes/dichloromethane) as eluent provided the title molecule as a white solid (0.0310 g, 18%).

Reference： [1]Patent: WO2016/99929,2016,A1 .Location in patent: Page/Page column 87

25
[ 6826-24-0 ]
1-[6-chloro-4-(difluoromethyl)-2-pyridyl]-4-(oxetan-3-yl)piperazine [ No CAS ]
N-[4-(difluoromethyl)-6-[4-(oxetan-3-yl)piperazin-1-yl]-2-pyridyl]-5-phenyloxazol-2-amine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
68%	With [2-(di-tert-butylphosphino)-2?,4?,6?-triisopropyl-1,1?-biphenyl][2-((2-aminoethyl)phenyl)]palladium(II) chloride; sodium t-butanolate; In 1,4-dioxane; at 125℃; for 1.16667h;Microwave irradiation; Inert atmosphere;	[00292] l-[6-chloro-4-(difluoromethyl)-2-pyridyl]-4-(oxetan-3-yl)piperazine (50 mg, 0.16 mmol), <strong>[6826-24-0]5-phenyloxazol-2-amine</strong> (53 mg, 0.33 mmol) and sodium t-butoxide (32 mg, 0.33 mmol) were suspended in 1,4-dioxane (3 mL) and purged with N2 for several minutes before addition chloro(2-di-t-butylphosphino-2',4',6'-tri-i-propyl-l, - biphenyl)[2-(2-aminoethyl)phenyl] palladium(II) (-BuXPhos Palladacycle) (10 mg, 0.014 mmol). The mixture was microwaved at 125C for 70 minutes. The reaction was quenched with methanol (2 mL), diluted with dichloromethane (15 mL), washed with water (5 mL), brine (5 mL), dried over sodium sulfate, filtered and concentrated. The crude material was subjected to flash chromatography purification (12g silica; 0% to 5% to 10% of ethanol in ethyl acetate) to provide N-[4-(difluoromethyl)-6-[4- (oxetan-3-yl)piperazin-l-yl]-2-pyridyl]-<strong>[6826-24-0]5-phenyloxazol-2-amine</strong> (50 mg, 68%). XH NMR (300 MHz, CDC13) delta 7.55 (dd, J = 14.0, 6.7 Hz, 4H), 7.42 (t, J = 7.6 Hz, 2H), 7.35 - 7.25 (m, 2H), 6.68 (d, J = 56.0 Hz, 1H), 6.44 (s, 1H), 4.83 - 4.60 (m, 4H), 3.79 - 3.49 (m, 5H), 2.57 - 2.35 (m, 4H) ppm. ESI-MS m/z calc. 427.18, found 428.03 (M+l)+; Retention time: 0.67 minutes.

Reference： [1]Patent: WO2018/106643,2018,A1 .Location in patent: Paragraph 00292

26
[ 6826-24-0 ]
1-(3-bromo-5-methylphenyl)-4-(3-methyloxetan-3-yl)piperazine [ No CAS ]
N-[3-methyl-5-[4-(3-methyloxetan-3-yl)piperazin-1-yl]phenyl]-5-phenyloxazol-2-amine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
72%	With [2-(di-tert-butylphosphino)-2?,4?,6?-triisopropyl-1,1?-biphenyl][2-((2-aminoethyl)phenyl)]palladium(II) chloride; sodium t-butanolate; In 1,4-dioxane; at 125℃; for 1.0h;Microwave irradiation; Inert atmosphere;	[00299] <strong>[6826-24-0]5-phenyloxazol-2-amine</strong> (63 mg, 0.39 mmol), l-(3-bromo-5-methyl- phenyl)-4-(3-methyloxetan-3-yl)piperazine (80 mg, 0.25mmol) and sodium t-butoxide (50 mg, 0.52 mmol) were suspended in 1,4-dioxane (4 mL) and purged with N2 for several minutes before addition of chloro(2-di-t-but lphosphino-2',4',6'-tri-i-propyl- l,r-biphenyl)[2-(2-aminoethyl)phenyl] palladium(II) (i-BuXPhos Palladacycle) (13 mg, 0.02 mmol). The mixture was microwaved at 125 C for 60 minutes. The reaction was quenched with methanol (2 mL) and diluted with dichloromethane. After filtration (Florisil/10 g), the excess solvent was evaporated under reduced pressure. The crude material was subjected to flash chromatography purification (12g silica; 0% to 5% of ethanol in ethyl acetate) to give N-[3-methyl-5-[4-(3- methyloxetan-3-yl)piperazin-l-yl]phenyl]-5-phenyl-oxazol-2-amine (75 mg, 72%). XH NMR (300 MHz, CDC13) delta 7.61 - 7.49 (m, 2H), 7.40 (t, J = 7.7 Hz, 2H), 7.26 (d, J = 7.4Hz, 1H), 7.17 (s, 1H), 7.03 (s, 1H), 6.93 (s, 1H), 6.79 (s, 1H), 6.47 (s, 1H), 4.71 (d, J = 5.5 Hz, 2H), 4.30 (d, J = 5.8 Hz, 2H), 3.49 - 3.18 (m, 4H), 2.74 - 2.45 (m, 4H), 2.35 (s, 3H) ppm. ESI-MS m/z calc. 404.22, found 405.28 (M+l)+; Retention time: 0.64 minutes.

Reference： [1]Patent: WO2018/106643,2018,A1 .Location in patent: Paragraph 00299

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Isomers

Technical Information

• 1,4-Addition of an Amine to a Conjugated Enone • 1,4-Addition of an Amine to a Conjugated Enone • Amides Can Be Converted into Aldehydes • Amine Synthesis from Nitriles • Amine Synthesis from Nitriles • Amines Convert Acyl Chlorides into Amides • Amines Convert Esters into Amides • Azide Reduction by LiAlH4 • Azide Reduction by LiAlH4 • Basicity of Amines • Benzylic Oxidation • Birch Reduction • Birch Reduction of Benzene • Blanc Chloromethylation • Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Chan-Lam Coupling Reaction • Chichibabin Reaction • Complete Benzylic Oxidations of Alkyl Chains • Complete Benzylic Oxidations of Alkyl Chains • Conversion of Amino with Nitro • Deprotonation of Methylbenzene • Diazotization Reaction • DIBAL Attack Nitriles to Give Ketones • Directing Electron-Donating Effects of Alkyl • Electrophilic Chloromethylation of Polystyrene • Enamine Formation • Formation of an Amide from an Amine and a Carboxylic Acid • Formation of an Amide from an Amine and a Carboxylic Acid • Friedel-Crafts Alkylation of Benzene with Acyl Chlorides • Friedel-Crafts Alkylation of Benzene with Carboxylic Anhydrides • Friedel-Crafts Alkylation Using Alkenes • Friedel-Crafts Alkylations of Benzene Using Alkenes • Friedel-Crafts Alkylations Using Alcohols • Friedel-Crafts Reaction • Groups that Withdraw Electrons Inductively Are Deactivating and Meta Directing • Halogenation of Benzene • Hemiaminal Formation from Amines and Aldehydes or Ketones • Hemiaminal Formation from Amines and Aldehydes or Ketones • Hofmann Elimination • Hofmann Rearrangement • Hydride Reductions • Hydrogenation to Cyclohexane • Hydrogenolysis of Benzyl Ether • Hydrolysis of Imines to Aldehydes and Ketones • Imine Formation from Amines and Aldehydes or Ketones • Leuckart-Wallach Reaction • Mannich Reaction • Methylation of Ammonia • Methylation of Ammonia • Nitration of Benzene • Nitrosation of Amines • Nucleophilic Aromatic Substitution • Nucleophilic Aromatic Substitution with Amine • Oxidation of Alkyl-substituted Benzenes Gives Aromatic Ketones • Peptide Bond Formation with DCC • Petasis Reaction • Preparation of Alkylbenzene • Preparation of Amines • Preparation of LDA • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reduction of an Amide to an Amine • Reduction of an Amide to an Amine • Reductive Amination • Reductive Amination • Reductive Removal of a Diazonium Group • Reverse Sulfonation——Hydrolysis • Ring Opening of Azacyclopropanes • Ring Opening of Azacyclopropanes • Ring Opening of Oxacyclobutanes • Specialized Acylation Reagents-Vilsmeier Reagent • Strecker Synthesis • Sulfonation of Benzene • Synthesis of 2-Amino Nitriles • The Acylium Ion Attack Benzene to Form Phenyl Ketones • The Claisen Rearrangement • The Nitro Group Conver to the Amino Function • Ugi Reaction • Vilsmeier-Haack Reaction

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P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	Inquiry	{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price) ]}	{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]}	Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price) ]}	{[ item.pr_usastock ]}		{[ item.pr_chinastock ]}	{[ item.pr_remark ]}

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 6826-24-0 ] {[proInfo.proName]}

Quality Control of [ 6826-24-0 ]

Related Doc. of [ 6826-24-0 ]

Product Details of [ 6826-24-0 ]

Calculated chemistry of [ 6826-24-0 ] Expand+

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 6826-24-0 ]

Application In Synthesis of [ 6826-24-0 ]

[ 6826-24-0 ] Synthesis Path-Downstream 1~26

Technical Information

Related Functional Groups of [ 6826-24-0 ]

Aryls

Amines

Related Parent Nucleus of [ 6826-24-0 ]

Oxazoles

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 6826-24-0 ]

Related Parent Nucleus of
[ 6826-24-0 ]