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Chemical Structure| 68535-57-9 Chemical Structure| 68535-57-9

Structure of 68535-57-9

Chemical Structure| 68535-57-9

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Product Details of [ 68535-57-9 ]

CAS No. :68535-57-9
Formula : C9H7NOS
M.W : 177.22
SMILES Code : OC1=CC=C(C2=CSC=N2)C=C1
MDL No. :MFCD17977224

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Application In Synthesis of [ 68535-57-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 68535-57-9 ]

[ 68535-57-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 71597-85-8 ]
  • [ 34259-99-9 ]
  • [ 68535-57-9 ]
YieldReaction ConditionsOperation in experiment
With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In 1,4-dioxane; water; at 90℃; for 3h;Inert atmosphere; In a 100mL three-necked flask, were added 4-hydroxyphenyl boronic acid (10.0g, 61.4mmol), 4- bromothiazole (10.2g, 73.7mmol), potassium carbonate (25.4g, 184.2mmol), 1,4- dioxane (30mmol), water (10mL) and bis triphenylphosphine palladium dichloride (2.15g, 3.07mmol). Under nitrogen, the reaction system was heated to 90 , stirred for 3h. Concentrated under reduced pressure to remove the solvent by distillation, the residue was dissolved in ethyl acetate (100 mL), saturated brine was added, extracted liquid separation. The combined organic phases were dried over anhydrous sodium sulfate, filtered, and concentrated to give the crude product as a pale yellow oil, purified by column chromatography to give the title product as a beige solid.
 

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