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Chemical Structure| 68755-40-8 Chemical Structure| 68755-40-8

Structure of 68755-40-8

Chemical Structure| 68755-40-8

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Product Details of [ 68755-40-8 ]

CAS No. :68755-40-8
Formula : C10H10F3N
M.W : 201.19
SMILES Code : NC1CCC2=C1C=C(C(F)(F)F)C=C2
MDL No. :MFCD18207628
InChI Key :ZLXDFXSCHGSKFJ-UHFFFAOYSA-N
Pubchem ID :22754127

Safety of [ 68755-40-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 68755-40-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 68755-40-8 ]

[ 68755-40-8 ] Synthesis Path-Downstream   1~1

YieldReaction ConditionsOperation in experiment
A solution of 770 mg. of the above oxime acetate was prepared in 5 ml. of THF. The solution was cooled in an ice bath to which was added, in dropwise fashion, 12 ml. of a 1 M diborane solution in THF. The reaction mixture was stirred at room temperature overnight after which time the solvent was removed by evaporation. 20 ml. of water were added to decompose any remaining borohydride. The reaction mixture was extracted twice with ether. The ether extracts were combined and the combined extracts washed twice with 50 ml. portions of 2 N aqueous hydrochloric acid. The acidic extracts were combined and made basic with 5 N aqueous sodium hydroxide. The alkaline layer was in turn extracted twice with ether. The ether extracts were combined and the combined extracts washed once with water, once with saturated aqueous sodium chloride and were then dried. Evaporation of the ether yielded 293 mg. of a yellow oil comprising 6-trifluoromethyl-1-aminoindane formed in the above reduction.
 

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