There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
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CAS No. : | 68797-27-3 | MDL No. : | |
Formula : | C6H12N2O4 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 176.17 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Danger | Class: | 9 |
Precautionary Statements: | P260-P264-P273-P301+P312-P305+P351+P338-P314 | UN#: | 3077 |
Hazard Statements: | H302-H319-H372-H410 | Packing Group: | Ⅲ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | 2,2-Dimethoxyethylamine (36.8 mL, 334 mmol)The solution in ethanol (40 mL, 1 relative volume) was charged to warm (50 C) over a period of 10 min.Ethyl 2-amino-2-oxo-acetate (40 g, 334.76 mmol)In a suspension in ethanol (320 mL, 8 relative volumes).The reaction was heated to reflux (80 C) and the reaction was monitored by HPLC.The solid precipitated during the reaction.Once completed, the reaction mixture was gradually cooled to ambient temperature over 4 h.The solid product is filtered,Wash with ethanol and dry overnight in a vacuum oven at 60 C to leave N'-(2,2-dimethoxyethyl) oxalic acid as a white fluffy solid (53.5 g, 99.1% purity, 90% yield ). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
77% | With copper(l) iodide; potassium carbonate; trans-N,N'-dimethylcyclohexane-1,2-diamine In N,N-dimethyl-formamide at 50 - 110℃; for 19h; Inert atmosphere; | 4.3 Step 3: 3-[[2-(2,2-Dimethoxyethylamino)-2-oxo-acetyl]amino]-5-fluoro-4-methyl-benzoic acid 3-Fluoro-5-iodo-4-methyl-benzoic acid (40 g, 141.41 mmol, 1.0 eq.),N'-(2,2-dimethoxyethyl) oxalic acid amide (30.2 g, 170 mmol, 1.2 eq.)And potassium carbonate (39.1 g, 283 mmol, 2.0 equivalents)Placed in a condenser,Nitrogen/vacuum inlet and overhead mixer in a 500 mL jacketed vessel.Add DMF (320 mL, 8 relative volumes)The mixture was stirred vigorously to keep all solids suspended.Loading trans-(1R,2R)-N,N'-dimethyl-1,2-cyclohexanecarboxamide(7.04mL, 42.4mmol, 0.3 equivalents)The mixture was degassed by a needle through a subsurface.The mixture was heated to 50 ° C,Cuprous iodide (8.24 g, 42.4 mmol, 0.3 eq.) was then charged to the suspension.The mixture was stirred at 110 ° C for 19 h under a nitrogen atmosphere.It is then cooled to ambient temperature.The dark green suspension was charged with 20 ° C ethanol (80 mL, 2 rel vols) and the contents of the vessel was slowly drained to a 2 L beaker containing 1 M citric acid (640 mL, 16 rel vol).The resulting slurry was diluted with water (200 mL, 5 EtOAc) and filtered.The filter cake was washed with water (4 x 200 mL) and dried in a vacuum oven at 60 ° C overnight to give a white solid.3-[[2-(2,2-dimethoxyethylamino)-2-oxo-acetyl]ammonium5-fluoro-4-methyl-benzoic acid (36.42 g, 98.9% purity, 77% yield). |