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COA NMR CNMR HPLC LC-MS

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Product Details of [ 691904-77-5 ]

CAS No. :	691904-77-5	MDL No. :	MFCD18396469
Formula :	C₁₂H₁₅FO₃	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	226.24	Pubchem ID :	-
Synonyms :

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 691904-77-5 ]

[ 691904-77-5 ] Synthesis Path-Downstream 1~9

1
[ 691904-76-4 ]
[ 691904-77-5 ]

Yield	Reaction Conditions	Operation in experiment
90%	With hydrogen In ethanol	34 Preparation 34Ethyl 3-(2-fluoro-4-methox-phenyl)propanoateA mixture of ethyl (E)-3-(2-fluoro-4-methoxy-phenyl)prop-2-enoate (11 g, 49 mmol) and 10% Pd/C catalyst (1.1 g) in ethanol (120 mL) is stirred overnight under hydrogen atmosphere with a balloon. The mixture is filtered through diatomaceous earth, washed with ethanol and the filtrate is evaporated to dryness to give the title compound (10 g, 90%). 1H NMR (400 MHz, DMSO-d6) δ 7.17 (t, J=8.8 Hz, 1H), 6.74 (d, J=12.4 Hz, 1H), 6.69 (d, J=8.4 Hz, 1H), 4.02 (q, J=7.2 Hz, 2H), 3.71 (s, 3H), 2.77 (t, J=7.6 Hz, 2H), 2.53 (t, J=7.6 Hz, 2H), 1.13 (t, J=7.2 Hz, 3H).
84%	With hydrogen In tetrahydrofuran; ethanol at 10 - 35℃;	24 Reference Example 24 Reference Example 24 ethyl 3-(2-fluoro-4-methoxyphenyl)-propanoate A mixture of ethyl (2E)-3-(2-fluoro-4-methoxyphenyl)-acrylate (7.07 g, 31.5 mmol), tetrahydrofuran (50 mL), ethanol (5 mL) and platinum dioxide (300 mg) was stirred overnight under a hydrogen atmosphere at room temperature. The catalyst was filtered off and the filtrate was concentrated. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=4:1) to give the title compound (5.97 g, yield 84%) as a colorless oil. 1H NMR (CDCl3) δ1.23(3H,t,J=7.2Hz), 2.58(2H,t,J=7.6Hz), 2.90(2H,t,J=7.6Hz), 3.77(3H,s), 4.12(2H,q,J=7.2Hz), 6.57-6.63(2H,m), 7.07-7.13(1H,m).
84%	With hydrogen In tetrahydrofuran; ethanol at 20℃;	28 A mixture of ethyl (2E)-3-(2-fluoro-4-methoxyphenyl)acrylate (7.07 g, 31.5 mmol), tetrahydrofuran (50 mL), ethanol (5 mL) and platinum oxide (300 mg) was stirred overnight at room temperature under a hydrogen atmosphere. The catalyst was filtered off, and the filtrate was concentrated. The residue was purified by silica gel column chromatography (20% ethyl acetate/hexane) to give the title compound (5.97 g, yield 84%) as a colorless oil. 1H NMR (CDCl3) δ: 1.23(3H, t, J=7.2Hz), 2.58(2H, t, J=7. 6Hz), 2.90(2H, t, J=7.6Hz), 3.77(3H, s), 4.12(2H, q, J=7.2Hz), 6.57-6.63(2H, m), 7.07-7.13(1H, m).

84%

With hydrogen In tetrahydrofuran; ethanol at 20℃;

13 ethyl 3- (2-fluoro-4-methoxyphenyl) propanoate A mixture of ethyl (2E)-3- (2-fluoro-4- methoxyphenyl) acrylate (7.07 g, 31.5 mmol), tetrahydrofuran (50 mL), ethanol (5 mL) and platinum oxide (300 mg) was stirred overnight under a hydrogen atmosphere at room temperature. The catalyst was filtered off and the filtrate was concentrated. The residue was purified by silica gel column chromatography (20% ethyl acetate/hexane) to give the title compound (5.97 g, yield 84%) as a colorless oil. 1H NMR (CDC13) 8 : 1.23 (3H, t, J=7.2Hz), 2.58 (2H, t, J=7.6Hz), 2.90 (2H, t, J=7.6Hz), 3.77 (3H, s), 4.12 (2H, q, J=7. 2Hz), 6.57- 6.63 (2H, m), 7.07-7. 13 (1H, mj.

Reference： [1]Current Patent Assignee: ROCHE HOLDING AG; ELI LILLY & CO; JUBILANT PHARMOVA LTD - US2011/92531, 2011, A1 Location in patent: Page/Page column 11
[2]Current Patent Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED - EP1698624, 2006, A1 Location in patent: Page/Page column 39
[3]Current Patent Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED - EP1731505, 2006, A1 Location in patent: Page/Page column 35-36
[4]Current Patent Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED - WO2005/63729, 2005, A1 Location in patent: Page/Page column 74

2
[ 691904-77-5 ]
[ 691904-78-6 ]

Yield	Reaction Conditions	Operation in experiment
99.75%	Stage #1: 3-(2-fluoro-4-methoxyphenyl)propionic acid ethyl ester With boron tribromide In dichloromethane at 0℃; for 0.5h; Stage #2: With ethanol In dichloromethane at 0℃;	55 Intermediate 55: Ethyl 3-(2-fluoro-4-hydroxyphenyl) propanoateTo a 25 mL RB flask fitted with magnetic stirrer was charged with 10 mL of dichloromethane. To the stirred solvent was added ethyl 3-(2-fluoro-4-methoxyphenyl) propanoate (0.45 g, 2 mmol). The reaction mixture was cooled to 0 °C and boron tribromide (0.45 mL) was added drop wise. After stirred for 30 minutes, the reaction mixture was quenched with ethanol (1 mL) at 0 °C by slow addition. The reaction mixture was concentrated to distill off the solvent; ethyl acetate (10 mL) was added. The organic layer was washed with saturated NaHC03 solution (10 mL), followed by brine solution (10 mL). The organic layer was dried over anhydrous Na2S04 and the solvent was removed under reduced pressure. The product was obtained as colorless oil (0.421 g, yield: 99.75%). 1H NMR (300 MHz, CDCI3): δ 6.93-6.99(1, 1 H), 6.43-6.48(m, 2H), 5.54(s, 1H), 4.02-4.09(q, 2H), 2.79-2.85(t, 2H), 2.50-2.55(t, 2H), 1.14-1.19(t, 3H).
83%	Stage #1: 3-(2-fluoro-4-methoxyphenyl)propionic acid ethyl ester With aluminum (III) chloride; Octanethiol In dichloromethane at 10 - 35℃; for 2h; Stage #2: With water In dichloromethane at 0℃; for 0.5h;	25 Reference Example 25 Reference Example 25 ethyl 3-(2-fluoro-4-hydroxyphenyl)-propanoate To a solution of ethyl 3-(2-fluoro-4-methoxyphenyl)-propanoate (57.4 g, 254 mmol) and aluminum chloride (101 g, 761 mmol) in dichloromethane (250 mL) was added dropwise 1-octanethiol (74.3 g, 508 mmol) and the mixture was stirred at room temperature for 2 hr. The reaction mixture was poured into ice water and the mixture was stirred for 30 min. The organic layer was separated, washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=4:1) to give the title compound (44.6 g, yield 83%) as a colorless oil. 1H NMR (CDCl3) δ1.23(3H,t,J=7.2Hz), 2.58(2H,t,J=8.1Hz), 2.89(2H,t,J=8.1Hz), 4.12(2H,q,J=7.2Hz), 6.51-6.56(2H,m), 7.01-7.06(1H,m).
83%	With aluminum (III) chloride; Octanethiol In dichloromethane at 20℃; for 2h;	29 To a solution of ethyl 3-(2-fluoro-4-methoxyphenyl)propanoate (57.4 g, 254 mmol) and aluminum chloride (101 g, 761 mmol) in dichloromethane (250 mL) was added dropwise 1-octanethiol (74.3 g, 508 mmol), and the mixture was stirred at room temperature for 2 hr. The reaction mixture was poured into ice water, and the mixture was stirred for 30 min. The organic layer was separated, washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (20% ethyl acetate/hexane) to give the title compound (44.6 g, yield 83%) as a colorless oil. 1H NMR (CDCl3) δ: 1.23(3H, t, J=7.2Hz), 2.58(2H, t, J=8.1Hz), 2.89(2H, t, J=8.1Hz), 4.12(2H, q, J=7.2Hz), 6.51-6.56(2H,m), 7.01-7.06(1H, m).

83%	With aluminum (III) chloride; Octanethiol In dichloromethane at 20℃; for 2h;	14 ethyl 3- (2-fluoro-4-hydroxyphenyl) propanoate To a solution of ethyl 3- (2-fluoro-4- methoxyphenyl) propanoate (57.4 g, 254 mmol) and aluminum chloride (101 g, 761 mmol) in dichloromethane (250 mL) was added dropwise 1-octanethiol (74.3 g, 508 mmol) and the mixture was stirred at room temperature for 2 hrs. The reaction mixture was poured into ice water and the mixture was stirred for 30 min. The organic layer was separated, washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (20% ethyl acetate/hexane) to give the title compound (44.6 g, yield 83%) as a colorless oil. 1H NMR (CDC13) 8 : 1.23 (3H, t, J=7.2Hz), 2.58 (2H, t, J=8. 1Hz), 2.89 (2H, t, J=8. lHz), 4.12 (2H, q, J=7. 2Hz), 6.51-6. 56 (2H, m), 7.01-7. 06 (1H, m)
80%	With boron tribromide In dichloromethane at -78 - 20℃; for 3h;	7.C [393] Step C: 3-(2-fluoro-4-hydroxy-phenyl)-propionic acid ethyl ester [393] Step C: 3-(2-fluoro-4-hydroxy-phenyl)-propionic acid ethyl ester [394] 3-(2-Fluoro-4-methoxy-phenyl)-propionic acid ethyl ester (2.5 g, 11.05mmol) obtained in Step B was dissolved in anhydrous DCM (10 mL). 1M BBr3solution (33 mL, 33.15 mmol) was added thereto at -78, and the mixture was stirredat room temperature for 3 hours. After the termination of the reaction, MeOHwas added to the reactant. The mixture was concentrated under reduced pressureand purified by column chromatography (eluent, EtOAc/Hex = 1/2) to obtain thetitle compound (1.88 g, 80%).[395] 1H NMR (400 MHz, CDCl3)δ 7.03(1H, t, 8Hz), 6.55-6.51(2H, m), 5.38(1H, brs), 4.13(2H, q, 7Hz),2.89(2H, t, 8Hz), 2.59(2H, t, 8Hz), 1.24(3H, t, 7Hz)

Reference： [1]Current Patent Assignee: CONNEXIOS LIFE SCIENCES PVT - WO2012/11125, 2012, A1 Location in patent: Page/Page column 102-103
[2]Current Patent Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED - EP1698624, 2006, A1 Location in patent: Page/Page column 40
[3]Current Patent Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED - EP1731505, 2006, A1 Location in patent: Page/Page column 36
[4]Current Patent Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITED - WO2005/63729, 2005, A1 Location in patent: Page/Page column 74-75
[5]Current Patent Assignee: LG CHEM CO.,LTD. - WO2014/69963, 2014, A1 Location in patent: Paragraph 393-395

Yield	Reaction Conditions	Operation in experiment
97%	With palladium 10% on activated carbon; hydrogen In ethanol at 20℃; for 12h;	7.B [342] Step D: 3-(3,5-difluoro-4-hydroxy-phenyl)-propionic acid ethyl ester General procedure: [342] Step D: 3-(3,5-difluoro-4-hydroxy-phenyl)-propionic acid ethyl ester [343] (E)-3-(4-Benzyloxy-3,5-difluoro-phenyl)-acrylic acid ethyl ester(1.2 g, 3.77 mmol) obtained in Step C was dissolved in EtOH (20 mL), and 10%Pd/C (120 mg) was added to the solution. The mixture was stirred at roomtemperature under hydrogen atmosphere for 12 hours. The reactant was filteredby using celite and concentrated under reduced pressure to obtain the titlecompound (0.85 g, 98%).[344] 1H NMR (400 MHz, CDCl3)δ 6.77(d, 2H), 4.11(q, 2H), 2.83(t, 2H), 2.59(t, 2H), 1.22(t, 3H)
84%		R.135 Reference Example 135 ethyl 3-(2-fluoro-4-methoxyphenyl)propionate The title compound was obtained as a colorless oil in the same manner as in Reference Example 43 from ethyl (2E)-3-(2-fluoro-4-methoxyphenyl)acrylate and platinum oxide. yield 84%. 1H NMR (CDCl3) δ 1.23 (3 H, t, J=7.2 Hz), 2.58 (2 H, t, J=7.6 Hz), 2.90 (2 H, t, J=7.6 Hz), 3.77 (3 H, s), 4.12 (2 H, q, J=7.2 Hz), 6.57-6.63 (2 H, m), 7.07-7.13 (1 H, m).

4
[ 691904-77-5 ]
[ 1356600-28-6 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1.1: boron tribromide / dichloromethane / 0.5 h / 0 °C 1.2: 0 °C 2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

Reference： [1]Current Patent Assignee: CONNEXIOS LIFE SCIENCES PVT - WO2012/11125, 2012, A1

5
[ 691904-77-5 ]
[ 1356598-92-9 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: boron tribromide / dichloromethane / 0.5 h / 0 °C 1.2: 0 °C 2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere 3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 0 °C 3.2: 20 °C / pH 3

Reference： [1]Current Patent Assignee: CONNEXIOS LIFE SCIENCES PVT - WO2012/11125, 2012, A1

6
[ 1269763-69-0 ]
[ 691904-77-5 ]

Yield	Reaction Conditions	Operation in experiment
91.58%	With hydrogen In ethyl acetate at 20℃; for 2h;	36 Intermediate 54: Ethyl 3-(2-fluoro-4-methoxyphenyl) propanoateTo a 500 mL parr shaker flask was charged with ethyl (2E, 2Z)-3-(2-fluoro-4- methoxyphenyl) prop-2-enoate (0.5 g, 2.2 mmol) and ethyl acetate (15 mL) and purged with nitrogen for 10 minutes. Palladium hydroxide (20%) was added and kept for hydrogenation at 50 psi for 2 h. After completion of the reaction, the reaction mixture was filtered through celite, washed thoroughly with ethyl acetate (25 mL) and concentrated to distill off the solvent. The product was obtained as brown solid (0.462 g, yield: 91.58%). 1H NMR (300 MHz, CDCI3): δ 7.00-7.06(t, 1H), 6.50-6.56(m, 2H), 4.01-4.09(q, 2H), 3.70(s, 3H), 2.81-2.86(t, 2H), 2.49- 2.54(t, 2H), 1.14-1.19(t, 3H).

Reference： [1]Current Patent Assignee: CONNEXIOS LIFE SCIENCES PVT - WO2012/11125, 2012, A1 Location in patent: Page/Page column 102-103

7
[ 867-13-0 ]
[ 331-64-6 ]
[ 691904-77-5 ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: diethoxyphosphoryl-acetic acid ethyl ester With sodium hydride In tetrahydrofuran at 0 - 50℃; for 1h; Stage #2: 2-fluoro-4-methoxy-benzaldehyde In tetrahydrofuran at 0℃; for 16h; Reflux; Stage #3: With hydrogen In ethanol for 4h;	6.A An oven dried flask was charged with sodium hydride (60 %) (389 mg, 9.73 mmol) and THF (25 mL) and cooled to 0 °C. Triethyl phosphonoacetate (1.948 mL, 9.73 mmol) was added dropwise and the reaction was heated to 50 °C for lhr. The reaction was then cooled to 0 °C, and 2-fluoro~ 4-methoxy-benzaldehyde (1000 mg, 6.49 mmol) was added via cannula in THF (4 5 mL). The reaction was then heated at reflux for 16 hours. Next, the reaction was cooled to roomtemperature and diluted with ethyl acetate (75 mL). The organic layer was washed with water (2 x 75 mL) and brine (75 mL), dried over sodium sulfate, filtered, and concentrated. The residue was dissolved in ethanol (20 mL) and 10% palladium on carbon (100 mg) was added. The reaction was placed under an atmosphere of (balloon) and stirred for 4 hours. The reaction was then filtered and concentrated. Purification of the residue via flash chromatography on silica gel (0 to 40% ethyl acetate/hexanes) afforded ethyl 3-(2-fluoro-4-methoxyphenyl)propanoate. NMR (CDC13, 500 MHz) δ 7.09 (t, J= 8.5 Hz, 1H), 6.60 (m, 2H), 4.12 (q, J= 7.2 Hz, 2H), 3.77 (s, 3H), 2.90 (t, J= 7.6 Hz, 2H), 2.58 (t, J= 7.7 Hz, 2H)5 1.23 (t, J= 7.2 Hz, 3H).

Reference： [1]Current Patent Assignee: MERCK & CO INC - WO2012/58187, 2012, A1 Location in patent: Page/Page column 43

8
[ 691904-77-5 ]
[ 1374134-23-2 ]

Yield	Reaction Conditions	Operation in experiment
	With iodine; silver sulfate In ethanol at 20℃; for 1h;	6.B Ethyl 3~(2-fluoro-4~methoxyphenyl)propanoate (1480 mg, 6.54 mmol) was dissolved in ethanol (60 mL). Iodine (1660 mg, 6.54 mmol) and silver sulfate (2040 mg, 6.54 mmol) were added and the reaction was stirred vigorously at room temperature, protected from light, for 1 hr. The reaction was then diluted with ethyl acetate (100 mL) and filtered. The filtrate was washed with sodium bisulfite (2 x 60 mL), water (70 mL), and brine (70 mL). The organic layer was dried over sodium sulfate, filtered, and concentrated. The residue was purified by flashchromatography on silica gel with 0 to 50% ethyl acetate/hexanes to afford ethyl 3-(2-fIuoro-5- iodo-4-methoxyphenyl)propanoate. NMR (CDCI3, 500 MHz) δ 7.59 (d, J= 8.4 Hz, 1H), 6,55 (d, J= 11.6 Hz, 1H), 4.13 (q, J= 7.1 Hz, 2H)S 3.84 (s, 3H), 2.87 (t, J= 7.6 Hz, 2H), 2.57 (t, J= 7.6 Hz, 2H), 1.24 (t, J= 7.1 Hz, 3H).

Reference： [1]Current Patent Assignee: MERCK & CO INC - WO2012/58187, 2012, A1 Location in patent: Page/Page column 43; 44

9
[ 691904-77-5 ]
[ 1374134-22-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: iodine; silver sulfate / ethanol / 1 h / 20 °C 2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / dimethyl sulfoxide / 2 h / 60 °C / Inert atmosphere

Reference： [1]Current Patent Assignee: MERCK & CO INC - WO2012/58187, 2012, A1

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P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 691904-77-5 ] {[proInfo.proName]}

Quality Control of [ 691904-77-5 ]

Related Doc. of [ 691904-77-5 ]

Product Details of [ 691904-77-5 ]

Safety of [ 691904-77-5 ]

Application In Synthesis of [ 691904-77-5 ]

[ 691904-77-5 ] Synthesis Path-Downstream 1~9

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry