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Chemical Structure| 692059-41-9 Chemical Structure| 692059-41-9

Structure of 692059-41-9

Chemical Structure| 692059-41-9

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Product Details of [ 692059-41-9 ]

CAS No. :692059-41-9
Formula : C12H12Cl2N2O2
M.W : 287.14
SMILES Code : COC1=CC2=NC=NC(Cl)=C2C=C1OCCCCl
MDL No. :MFCD25966244

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 692059-41-9 ]

[ 692059-41-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 574745-97-4 ]
  • [ 627-30-5 ]
  • [ 692059-41-9 ]
YieldReaction ConditionsOperation in experiment
With 2,2'-azobis(isobutyronitrile); triphenylphosphine; In dichloromethane; at 20℃; for 3h; Di-tert-butyl azodicarboxylate (1.84 g) was added portionwise over a few minutes to a stirred mixture of <strong>[574745-97-4]4-chloro-6-hydroxy-7-methoxyquinazoline</strong> (1.2 g), 3-chloropropanol (0.572 ml), triphenylphosphine (2.1 g) and methylene chloride (30 ml) and the reaction mixture was stirred at ambient temperature for 3 hours. The mixture was evaporated and the residue was purified by column chromatography on silica using increasingly polar mixtures of methylene chloride and ethyl acetate as eluent. The material so obtained was triturated under diethyl ether. The resultant solid was isolated and dried under vacuum. There was thus obtained 4-CHLORO-6- (3-CHLOROPROPOXY)-7-METHOXYQUINAZOLINE as a white solid (0.84 g); NMR Spectrum: (CDCl3) 2.4 (m, 2H), 3.8 (t, 2H), 4.05 (s, 3H), 4.35 (t, 2H), 7.35 (s, 1H), 7.45 (s, 1H), 8.9 (s, 1H)
 

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