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Chemical Structure| 69433-07-4 Chemical Structure| 69433-07-4

Structure of 69433-07-4

Chemical Structure| 69433-07-4

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Product Details of [ 69433-07-4 ]

CAS No. :69433-07-4
Formula : C5H9ClN2O
M.W : 148.59
SMILES Code : O=C(Cl)N1CCNCC1
MDL No. :MFCD13173532

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Application In Synthesis of [ 69433-07-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 69433-07-4 ]

[ 69433-07-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 69433-07-4 ]
  • [ 38183-03-8 ]
  • 4-oxo-2-phenyl-4H-chromene-7,8-diyl bis(piperazine-1-carboxylate) dihydrochloride [ No CAS ]
YieldReaction ConditionsOperation in experiment
With dmap; In dichloromethane; at 20℃; General procedure: A solution of isonicotinic acid (600 mg, 4.9 mmol) in SOCh (20 mL) was refluxed overnight under Ar atmosphere. Then the resulting mixture was evaporated under reduced pressure to remove the SOCh, the residue was used for the next step directly without further purification. <strong>[38183-03-8]<strong>[38183-03-8]7,8-Dihydroxyflavon</strong>e</strong> (200 mg, 0.8 mmol) was added to a solution of DMAP (1.2 g, 4.8 mmol) and isonicotinoyl chloride (690 mg, 4.9 mmol) in DCM (5 mL), and the mixture was stirred at r.t. overnight. The mixture was filtered and evaporated under reduced pressure. The residue was washed by ethyl ether to afford the product as a white solid (80 mg, yield: 21.9%). The product was confirmed by HPLC, LCMS and NMR. NMR (400 MHz, CDCh): 5ppm 8.89 (d, J = 6.0 Hz, 2H), 8.83 (d, J = 6.0 Hz, 2H), 8.28 (d, J = 8.8 Hz, 1H), 7.99-8.00 (m, 2H), 7.91-7.92 (m, 2H), 7.67-7.69 (m, 2H), 7.46-7.48 (m, 2H), 7.36-7.40 (m, 2H), 6.86(s, 1H). Purity: 93.7% (254 nm); MS: 465.0 [M+l]+
 

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