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Chemical Structure| 69741-69-1 Chemical Structure| 69741-69-1

Structure of 69741-69-1

Chemical Structure| 69741-69-1

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Product Details of [ 69741-69-1 ]

CAS No. :69741-69-1
Formula : C11H14ClNO
M.W : 211.69
SMILES Code : CC(C)C(C1=CC=C(Cl)C=C1)C(N)=O
MDL No. :MFCD11643424

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Application In Synthesis of [ 69741-69-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 69741-69-1 ]

[ 69741-69-1 ] Synthesis Path-Downstream   1~2

  • 2
  • [ 79-37-8 ]
  • [ 2012-74-0 ]
  • [ 69741-69-1 ]
YieldReaction ConditionsOperation in experiment
With ammonia; In N,N-dimethyl-formamide; EXAMPLE 1 To a solution of 4.25 g (20 mmol) of 2-(4-chlorophenyl)-3-methylbutanoic acid in 30 ml of ether containing one drop of N,N-dimethylformamide is added dropwise 3.81 g (30 mmol) of oxalyl chloride. The solution is stirred at RT until gas evolution ceases. The solvent and excess oxalyl chloride are removed in vacuo and the residue is taken up in 30 ml of ether. This solution is then added dropwise at 0-5 to 4.86 g (40 mmol) of a 14% w/w aqueous solution of ammonia. After stirring the mixture for 30 minutes at 0-5, the aqueous layer is removed. The ethereal solution is washed with water, dried over sodium sulfate, filtered and concentrated in vacuo to obtain 2-(4-chlorophenyl)-3-methylbutyramide.
 

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