Alternatived Products of [ 698-33-9 ]
Product Details of [ 698-33-9 ]
CAS No. : | 698-33-9 |
MDL No. : | MFCD00223701 |
Formula : |
C6H7ClN2O
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | SEPGLLQTLDBFAY-UHFFFAOYSA-N |
M.W : |
158.59
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Pubchem ID : | 22152271 |
Synonyms : |
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Application In Synthesis of [ 698-33-9 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 698-33-9 ]
Yield | Reaction Conditions | Operation in experiment |
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4-Hydroxy-5-methoxy-2-methyl-pyrimidin, sd. POCl3 <N.N-Dimethylanilin>; |
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4-Hydroxy-5-methoxy-2-methyl-pyrimidin, sd. POCl3 <Dimethylanilin> (45min); |
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8.b (b)
(b) 4-Chloro-2-methyl-5-methoxypyrimidine The material prepared in part (a) (4.0 g, 8.5 mmol) was placed in a round bottomed flask and distilled POCl3 (12 ml) was added carefully. This mixture was heated under reflux under N2 until dissolution had occurred (approximately 30 minutes) and then for an additional 45 minutes. The excess POCl3 was removed by distillation and the remaining material was passed onto ice-H2 O. This mixture was then rendered basic by the addition of NH4 OH and the precipitate which formed was filtered off and air-dried. An additional amount of product was obtained by extraction of the filtrate with CHCl3 NMR (CDCl3, δ from TMS): 2.67 (S, CH3), 4.01 (S, OCH3), 8.25 (S, H6). Calculated for C6 H7 N2 ClO: C, 45.44; H, 4.45; N, 17.66 Found: C, 45.24; H, 4.59; N, 17.47. |
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[ 698-35-1 ]
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[ 698-33-9 ]
Yield | Reaction Conditions | Operation in experiment |
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6 4-chloro-2-methyl-5-methoxypyrimidine
Example 6 4-chloro-2-methyl-5-methoxypyrimidine Operating as described above and starting out from 14 g (0.1 mol) of 4-hydroxy-2-methyl-5-methoxy pyrimidine, 12.3 g (69.1%) of product in form of a white solid were yielded. |