Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||||
{[ item.p_purity ]} | {[ item.pr_size ]} | Login | Inquiry |
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price) ]} |
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price) ]} | {[ item.pr_usastock ]} | in stock Inquiry - | {[ item.pr_chinastock ]} | {[ item.pr_remark ]} in stock Inquiry - | Login | Inquiry |
Please Login or Create an Account to: See VIP prices and availability
CAS No. : | 69843-13-6 | MDL No. : | MFCD05667135 |
Formula : | C4H7N3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | LBGSWBJURUFGLR-UHFFFAOYSA-N |
M.W : | 97.12 | Pubchem ID : | 4770990 |
Synonyms : |
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
![]() |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
76% | To amixthxe of NaIl (0264 g, &F?4 35 nol) inTEF (50 nL)was added l-methyl-lH-pyrazd-4- amine (2Q97 g, 21.59 nunol). The niixiui was sthmd thrabc?at0.5 hat thc?at 0 C. A so1niiciof (5 g, 17S9 nunDl7 Aik Plmnn) iii TEF C30 iuL)was added slowlyardtlE leacthnnuetnewas siinedforlkat0t. Water(SmL)was a&Ied.Themixtur? was conetted to drjne. Adth&nal two reaction nuethrEs weze set up follcwing the above nitIiri1. All tluee batches were contimd, wa±er (109 mL) was added. The nuetm was extaDted with ECAc (3 x 5J0 niL).The orgaiiic pluse wa diied over NaSOi, comeitated urder iethixed piessuxe, parified ?ue silica gel ci ntognphyebath with 2S5]percent ECAc WE to give Cbvm9-N (J-ty1-SH-pwcroy1flL24]mo[L5-Q1yrc8-ani (12 g, 7A) as a wlite solid: ?H NMR (411 MH; DMSO-D6) 8 ppxw5 10.71 (s, 1H), 8.59-8.56 (d, J 12, 2H), 8i]7 (s, lii), 7.76 (, 1ff), 3.&5 (s, 3H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
66% | Step 1. Diethyl 2-((3-(1-methyl-1H-pyrazol-4-yl)ureido)methylene)malonate A mixture of 1-methyl-1H-pyrazol-4-amine (0.097 g, 1.0 mmol) and 1,1'-carbonyldiimidazole (0.178 g, 1.100 mmol) in DMSO (1 mL) was stirred at rt for 1 h, then diethyl 2-(aminomethylene)malonate (0.187 g, 1.00 mmol) was added to the solution. The reaction mixture was stirred at 80° C. overnight, cooled to rt, and directly purified via column chromatography (0percent to 100percent EtOAc in hexanes) to afford the product (0.204 g, 66percent). LCMS calcd for C13H19N4O5 (M+H)+: m/z=311.1. Found: 311.2. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; at 0 - 20℃; for 2h;Inert atmosphere; | To a mixture of 1 -methylpyrazol-4-amine (0.30 g, 3.09 mmol, 1 eq.) and 1 -methylpiperidine-4-carboxylic acid (442 mg, 3.09 mmol, 1 eq.) in pyridine (10 ml) was added 1 -ethyl-3 -(3- dimethylaminopropyl)carbodiimide hydrochloride (888 mg, 4.64 mmol, 1.5 eq.) in one portion at 0 °C under N2. The mixture was stirred at rt for 2 h. The mixture was concentrated in vacuo then diluted with water (10 ml). The aqueous phase was extracted with ethyl acetate (3 x 10 ml). The combined organic phase was washed with saturated brine (3 x 8 ml), dried over anhydrous Na2S04, filtered and concentrated in vacuo. The residue was purified by silica gel (1022) chromatography (10 - 50 percent MeOH in ethyl acetate) to give 1 -methyl-N-( 1 -methylpyrazol-4- yl)piperidine-4-carboxamide as a white solid. 'H NMR (400 MHz, DMSO-de) d = 9.83 (s, 1H), 7.90 - 7.78 (m, 1H), 7.82 (s, 1H), 7.44 - 7.29 (m, 1H), 5.89 - 5.70 (m, 1H), 3.75 (s, 2H), 3.02 - 2.93 (m, 1H), 3.02 - 2.93 (m, 1H), 2.78 (d, J=\2 Hz, 2H), 2.10 (s, 3H), 1.90 - 1.78 (m, 2H), 1.49- 1.45 (m,lH). |
[ 1063734-49-5 ]
1-Methyl-1H-pyrazol-4-amine dihydrochloride
Similarity: 0.97
[ 127107-23-7 ]
1-Methyl-1H-pyrazol-4-amine hydrochloride
Similarity: 0.97
[ 1896159-87-7 ]
N,1-Dimethyl-1H-pyrazol-4-amine dihydrochloride
Similarity: 0.93
[ 64517-88-0 ]
1,3-Dimethyl-1H-pyrazol-4-amine
Similarity: 0.82
[ 1063734-49-5 ]
1-Methyl-1H-pyrazol-4-amine dihydrochloride
Similarity: 0.97
[ 127107-23-7 ]
1-Methyl-1H-pyrazol-4-amine hydrochloride
Similarity: 0.97
[ 1896159-87-7 ]
N,1-Dimethyl-1H-pyrazol-4-amine dihydrochloride
Similarity: 0.93
[ 64517-88-0 ]
1,3-Dimethyl-1H-pyrazol-4-amine
Similarity: 0.82