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Chemical Structure| 69992-10-5 Chemical Structure| 69992-10-5

Structure of 69992-10-5

Chemical Structure| 69992-10-5

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Product Details of [ 69992-10-5 ]

CAS No. :69992-10-5
Formula : C14H17N5O6
M.W : 351.31
SMILES Code : O=C1C2=C(NC(N)=N1)N([C@@]3([H])C[C@@H]([C@H](O3)COC(C)=O)OC(C)=O)C=N2
MDL No. :MFCD03701159

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Application In Synthesis of [ 69992-10-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 69992-10-5 ]

[ 69992-10-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 69992-10-5 ]
  • [ 171723-95-8 ]
  • O<SUP>6</SUP>-(N-4-((hydroxymethyl)benzyl)trifluoroacetylmide)-3',5'-O-diacetyl-2'-deoxyguanosine [ No CAS ]
YieldReaction ConditionsOperation in experiment
75% With triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; at 20℃; for 4.0h;Inert atmosphere; 3’,5’-O-diacetyl-deoxyguanosine (2, 620 mg, 1.79 mmol) was dried 3 times by evaporation of DMF. PPh3 (1.42 g; 5.4 mmol, 3 eq) and the protected phenol (1, 500 mg, 2.15mmol, 1,2 eq) was added and left under vacuum for 2 h. Then, the mixture was dissolved in anhydrous dioxane (10.0 ml) and maintained under an argon atmosphere. Finally, DEAD (860 µl; 5.4 mmol 3 eq) was added dropwise. The reaction mixture was stirred for 4 hours at room temperature and the progressof the reaction was monitored by TLC (DCM:MeOH 9:1). The orange reaction was concentrated under vacuum to obtain a viscous oil. The oil was purified by flash chromatography using a gradient of MeOH in DCM to yield a white solid (750 mg,75%).
 

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