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CAS No. : | 700-06-1 | MDL No. : | MFCD00005632 |
Formula : | C9H9NO | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 147.17 | Pubchem ID : | - |
Synonyms : |
I3C;3-Indolemethanol;NSC 525801;3-Indolylmethanol;1H-Indole-3-methanol;Indinol;3-hydroxymethyl Indole
|
Num. heavy atoms : | 11 |
Num. arom. heavy atoms : | 9 |
Fraction Csp3 : | 0.11 |
Num. rotatable bonds : | 1 |
Num. H-bond acceptors : | 1.0 |
Num. H-bond donors : | 2.0 |
Molar Refractivity : | 44.43 |
TPSA : | 36.02 Ų |
GI absorption : | High |
BBB permeant : | Yes |
P-gp substrate : | No |
CYP1A2 inhibitor : | Yes |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -6.45 cm/s |
Log Po/w (iLOGP) : | 1.36 |
Log Po/w (XLOGP3) : | 1.06 |
Log Po/w (WLOGP) : | 1.51 |
Log Po/w (MLOGP) : | 0.96 |
Log Po/w (SILICOS-IT) : | 2.38 |
Consensus Log Po/w : | 1.45 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 1.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -1.96 |
Solubility : | 1.61 mg/ml ; 0.011 mol/l |
Class : | Very soluble |
Log S (Ali) : | -1.41 |
Solubility : | 5.76 mg/ml ; 0.0391 mol/l |
Class : | Very soluble |
Log S (SILICOS-IT) : | -3.09 |
Solubility : | 0.119 mg/ml ; 0.000809 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 0.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 1.05 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H315-H319 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
15% | With dmap; triethylamine In dichloromethane at 20℃; for 1 h; | To a solution of indole-3-carbinol (250 mg, 1.70 mmol) and (Boc)2O (371 mg, 1.70 mmol) in dichloromethane (6 mL) was added triethylamine (0.47 mL, 3.40 mmol) followed by DMAP (21 mg, 0.170 mmol). The reaction mixture was stirred at room temperature for 1 h and poured into water. The dichloromethane layer was separated, dried over Na2SO4 and concentrated. The crude product was purified by flash column chromatography on silica gel using 20percent-30percent EtOAc/hexanes as eluent to afford Boc protected indole as solid (60 mg, 0.243 mmol, 15percent). 1H NMR (CDCl3, 300 MHz): δ (ppm) 1.66 (s, 9H), 1.84 (br s, 1H), 4.82 (s, 2H), 7.22-7.36 (m, 2H), 7.57 (s, 1H), 7.64 (dd, 1H, J=0.6, 7.5 Hz), 8.14 (d, 1H, J=8.1 Hz). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
77% | With sodium hydroxide; In water; for 1h;Heating / reflux; | (a) 3,3'-Diindolylmethane (55). Indole-3-carbinol (54) (1.0 g, 6.79 mmol) in 10percent aqueous NaOH solution (100 mL) was refluxed for 1 h. The solution was cooled, neutralized with carbon dioxide and the white precipitate was collected by filtration, which was then crystallized from toluene to yield 55 as a white solid (0.65 g, 77percent): 1H NMR (300 MHz, CDCl3) delta 4.26 (s, 2, CH2), 6.94 (m, 2, PyH), 7.11 (m, 2, ArH), 7.21 (m, 2, ArH), 7.36 (m, 2, ArH), 7.64 (m, 2, ArH), 7.86 (br.s, 2, NH). |
With sodium hydroxide; In water; for 1h;Reflux; | Indole-3-carbinol (1.0 g, 6.79 mmol) in 10percent aqueous NaOH solution (100 mL) was refluxed for 1 h. The solution was cooled, neutralized with carbon dioxide and the white precipitate was collected by filtration, which was then crystallized from toluene to yield 3,3'-Diindolylmethane as a white solid (0.65 g, 77percent): 1H NMR (300 MHz, CDCl3) delta 4.26 (s, 2, CH2), 6.94 (m, 2, PyH), 7.11 (m, 2, ArH), 7.21 (m, 2, ArH), 7.36 (m, 2, ArH), 7.64 (m, 2, ArH), 7.86 (br. s, 2, NH). | |
With hydrogen chloride; In d(4)-methanol; for 0.0833333h;Conversion of starting material; | OSU- A9 resists acid-catalyzed dimerization. We used a nuclear magnetic resonance (NMR) technique to analyze the chemical stability of OSU-A9 versus indole-3- carbinol in 0.1 N HCl by monitoring changes in the proton signal associated with CH2OH. Individual compounds (20 mg) were dissolved in 1 ml of deuterium-labeled methanol (CD3OD). The NMR spectra revealed signals for the methylene protons (indicated by *) at 4.73 ppm and 4.74 ppm for <strong>[700-06-1]indole-3-carbinol</strong> and OSU-A9, respectively (upper spectra, left and right panels). Addition of 100 mul of 0.1 N deuterium-labeled HCl to <strong>[700-06-1]indole-3-carbinol</strong> resulted in an immediate shift of the CH2 signal from 4.73 ppm to 4.66 ppm (t = 5 min), indicating the chemical transformation of <strong>[700-06-1]indole-3-carbinol</strong> to an acid reaction mixture consisting of DIM and other <n="38"/>oligomeric products. On the other hand, no appreciable change in the spectrum was noted after exposure of OSU- A9 to HCl for up to 8 h, indicating its significantly greater chemical stability. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
87% | With LACTIC ACID; dihydrogen peroxide; at 30℃; for 7h; | General procedure: A mixture of alcohol (1 mmol) and lactic acid (1 mL) was charged in 25 mL round bottom flask subjected to constant magnetic stirring at room temperature (30C). The reaction mixture was further activated by addition of 30% H2O2 (1.07 equiv.). The reaction progress was monitored by GC. After completion of the reaction, Dichloromethane (2×6 mL) was added to the reaction mixture and then washed with distilled water (2×2mL). The organic layer was separated and dried over Na2SO4 and removed under reduced pressure. The crude product was obtained by evaporation method and again purified by column chromatography using ethyl acetate and n-hexane as eluting system. |
82% | With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; copper diacetate; In water; acetonitrile; at 20℃; for 6h;Green chemistry; | General procedure: A mixture of alcohol (5.0 mmol), Cu(OAc)2 (9.1 mg, 0.05 mmol), and TEMPO (7.8 mg, 0.05 mmol) in CH3CN/H2O (5/10 mL) was stirred at room temperature for specified time. After completion of the reaction (monitored by TLC, eluents: petroleum ether/ethyl acetate = 4/1), dichloromethane (10 mL) was added to the resulting mixture. The dichloromethane phase was separated, and the aqueous phase was further extracted with dichloromethane (10 mL × 2). The combined organic layers were dried over anhydrous sodium sulfate and concentrated to give a residue, which was purified by column chromatography (eluents: petroleum ether/ethyl acetate = 10/1) to provide the desired product. |
72% | With magnetic polydopamine-wrapped Fe3O4 core-shell submicrosphere-supported nano-palladium; air; In o-xylene; at 120℃; for 24h;Sonication; | General procedure: Approximately 0.1 g of Fe3O4(at)PDAPd catalyst (2 mol% of Pd) was used. The aforementioned solidand liquor were separated using a magnet and placed under ultrasonic washing using 10 mL 3O-xylene. Then, 1 mmol of benzyl alcohol derivative and 5 mL of O-xylene were successively added and blended under ultrasonic conditions. The mixture was then magnetically stirred for 24 h under 120 C. After the reaction ended, the solid and liquor were separated using a magnet. The liquor wasconcentrated, and the dehydrogenation product could be obtained after purification through column chromatography (petroleum ether/ethyl acetate). |
43% | With 4,5,6,7-tetrachloro-2',4',5',7'-tetraiodofluorescein disodium salt; oxygen; ammonium thiocyanate; In acetonitrile; at 20℃; for 20h;Irradiation; | General procedure: A glass vial fitted with magnetic stirrer and a magnetic bar containing a reaction mixture of alcohol (0.1 mmol), NH4SCN (3 eq.), catalyst (5 mol%) and 2 ml of solvent. The vial was closed with rubber septum and O2 was bubbling for 15 minutes using needles. The reaction mixture was irradiated under a 23W CFL lamp for a certain time period. Reaction progress was monitored by TLC. After, completion of the reaction, a yellow solid was formed. The reaction mixture of three vials with the same content were combined and filter it through whatman filter paper. The mixture was evaporated under reduced pressure and purified by column chromatography using hexane/ethyl acetate as eluent. Further, the reaction mixture was run on a GC-MS instrument for characterisation. Yield, conversion and selectivity were calculated using following equations. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With 2,2-diphenyl-1-(2,4,6-trinitrophenyl)hydrazyl; at 20℃; for 0.5h;Reactivity (does not react); | In order to confirm the antioxidant activity of the compounds, a DPPH method was employed. DPPH (l,l-diphenyl-2-picrylhydrazyl) is a chromogenic radical and thus, can be used to directly confirm the radical scavenging activity of the samples. The samples were dissolved in 4 ml of distilled water or solvent (methanol) and then, mixed well with 1 ml of 100 muM DPPH. Subsequently, the samples were incubated at room temperature for 30 minutes. The absorbance of the remaining DPPH was measured at 517 nm. As a blank of the present experiment, distilled water or solvent was used, and as a control, an experimental group composed only of DPPH in distilled water or solvent without the sample was used. Further, vitamin C was used as a positive control. As a result, the antioxidant activity was expressed as percentages of the absorbance of each hydrolysate relative to the absorbance of control, as calculated by the following equation 1.[81][82] (Experimental Equation 1)[83]RSAW = Ab5 f hydfKylate chi l00 Abs of Control[84] (RSA: Radical Scavenging Activity)[85] |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
56% | With diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; | Following the same procedure used to synthesize 3-azidomethyl furan, indole-3-methanol (2.00 g, 13.6 mmol) was converted to 3-azidomethyl indole (1.31 g, 56%) as a yellow oil. 1H NMR (300 MHz, CDCl3) ? 8.19 (bs, 1H), ? 7.71 (d, 1H), ? 7.39 (m, 2H), ? 7.19 (m, 2H), ? 4.54 (s, 2H) ppm; 13C NMR (75 MHz, CDCl3) ? 130.3, 125.9, 125.3, 122.2, 120.3, 120.3, 119.7, 118.7, 111.9 ppm; LRMS (EI) calcd for C9H8N4 (M+) 172, found 172. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
15% | With dmap; triethylamine; In dichloromethane; at 20℃; for 1h; | To a solution of <strong>[700-06-1]indole-3-carbinol</strong> (250 mg, 1.70 mmol) and (Boc)2O (371 mg, 1.70 mmol) in dichloromethane (6 mL) was added triethylamine (0.47 mL, 3.40 mmol) followed by DMAP (21 mg, 0.170 mmol). The reaction mixture was stirred at room temperature for 1 h and poured into water. The dichloromethane layer was separated, dried over Na2SO4 and concentrated. The crude product was purified by flash column chromatography on silica gel using 20%-30% EtOAc/hexanes as eluent to afford Boc protected indole as solid (60 mg, 0.243 mmol, 15%). 1H NMR (CDCl3, 300 MHz): delta (ppm) 1.66 (s, 9H), 1.84 (br s, 1H), 4.82 (s, 2H), 7.22-7.36 (m, 2H), 7.57 (s, 1H), 7.64 (dd, 1H, J=0.6, 7.5 Hz), 8.14 (d, 1H, J=8.1 Hz). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70% | scandium tris(trifluoromethanesulfonate); In dichloromethane;Inert atmosphere; | To a mixture of 3-hydroxymethyl-indole (1.37 mmol) and indole (0.68 mmol) in CH2Cl2 (6 mL) was added (CF3SO3)3Sc (0.05 g) and stirred for overnight under argon. The solvent was evaporated to give a crude product. Flash chromatography (30% EtOAc/hexane) yielded 3,3'-(1H-indole-2,3-diyl)bis(methylene)bis(1H-indole) as a white solid (70%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
17.1% | With sodium; In toluene; for 10h;Heating; | Methyl indole-3-carboxylate (1.75 g, 0.01 mol) was dissolved in anhydrous toluene (80 ml) and 3-indolylmethanol (1.77 g, 0.12 mol) in 30 ml anhydrous toluene was added. Before addition of (0.1 g, 0.0043 mol) sodium, 10 ml of the toluene/water azeotrope was removed by distillation. The mixture was stirred at the solvent's boiling temperature for 10 h. To the obtained mixture 3 ml of methanol was added, then 50 ml of water. The organic phase was separated, washed in water and dried with MgSO4. The toluene was evaporated in vacuo. The oily residue of the crude product crystallized after several hours at 4 C (1.58 g, 51.97%). The crude precipitate was crystallized from ethanol/water (2:1); 0.52 g (17.10%) yield. M.p. 154.5-154.8 C.-IR (KBr): nu = 3450-3150 (N-H associated), 3120-3000, 3000-2800, 1662 (C=O), 1610, 1535, 1482, 1461, 1446, 1338 (C-N) cm-1. 1H NMR (299.87 MHz, DMSO) delta = 3.772 (s, 3H, 10-H), 5.607 (s, 2H, 8-H), 6.988 (td, J = 0.9 Hz, 1H, 5'-H), 7.073 (td, J = 1.2 Hz, 1H, 6'-H), 7.190 (td, J1 = 7.0 Hz, J2 = 1.0 Hz, 1H, 5-H), 7.241 (td, J1 = 7.0 Hz, J2 = 2.0 Hz, 1H, 6-H), 7.367 (bd, J = 8.0 Hz, 1H, 7'-H), 7.516 (bd, J = 8.0 Hz, 1H, 4'-H), 7.594 (d, J = 2.4 Hz, 1H, 2'-H), 7.796 (d, J = 2.0 Hz, 1H, 7-H), 7.969 (d, J = 8.1 Hz, 1H, 4-H), 8.203 (s, 1H, 2-H). 13C NMR (75.41 MHz, DMSO): delta = 41.78 (10-C), 50.62 (14-C), 105.17 (3-C), 109.51 (3'-C), 111.39 (7-C), 111.71 (7'-C), 118.27 (4'-C), 119.03 (5'-C), 120.63 (4-C), 121.42 (6'-C), 121.51 (5-C), 122.30 (6-C), 125.56 (2'-C), 126.19 (9'-C), 126.30 (9-C), 134.93 (2-C), 136.25 (8-C), 136.31 (8'-C), 164.43 (11-C) ppm. C19H16N2O2 (304.33): calcd. C 74.98, H 5.30, N 9.21; found C 74.98, H 5.38, N 9.21. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With triphenylphosphine; 1,1'-azodicarbonyl-dipiperidine; In tetrahydrofuran;Cooling with ice; | 0099] Step 7. A solution of l,l'-(azodicarbonyl)dipiperidine (9.2 g, 36.4 mmol) in THF was added dropwise over 1 h to a solution of 3-amino-5-butylphenol (5 g, 30.3 mmol), (1H- indol-3-yl)-methanol (5.3 g, 36.4 mmol) and PPh3 (9.5 g, 36.4 mmol) in THF (80 mL) at ice bath temperature. The mixture was concentrated and purified by preparative HPLC to afford 2- ((lH-indol-3-yl)methyl)-5-amino-3-butylphenol (10.5 g, crude, 8 batches). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
42% | With dmap; triethylamine; In dichloromethane; at 0℃;Inert atmosphere; Molecular sieve; | To an oven dried flask that cooled under argon was added the (1H-indol-3-yl)methanol (1.0 grams, 6.8 mmol, 0.1M in dry dichloromethane, purchased from Fisher Scientific, stored over 4 angstrom molecular sieves) and DMAP (0.083 grams, 0.68 mmol). While stirring at 0 C., triethyl amine (2.0 mL, 14.3 mmol, purchased from Fisher Scientific) was added followed by benzoyl chloride (0.96 mL, 8.2 mmol, purchased from Fisher Scientific). Once the reaction was complete it was diluted with water, and the organic layer removed. The aqueous layer was then washed with dichloromethane twice and the organic material combined. The organic material was dried with sodium sulfate, filtered, and concentrated. Purification using a Teledyne ISCO on silica support (hexanes/ethyl acetate gradient) afforded the desired 1-benzoyl-1H-indol-3-yl)methyl benzoate. 42% yield. 1H-NMR delta 8.42 (d, 1H), 8.02 (dd, 2H), 7.76 (m, 3H), 7.62 (dd, 1H), 7.54 (m, 3H), 7.47-7.37 (m, 5H), 5.50 (s, 2H). |
42% | With dmap; triethylamine; In dichloromethane; at 0℃; | 1-Benzoyl-1H-indol-3-yl)methyl benzoate To an oven dried flask that cooled under argon was added the (1H-indol-3-yl)methanol (1.0 grams, 6.8 mmol, 0.1M in dry dichloromethane, purchased from Fisher Scientific, stored over 4 angstrom molecular sieves) and DMAP (0.083 grams, 0.68 mmol). While stirring at 0 C., triethyl amine (2.0 mL, 14.3 mmol, purchased from Fisher Scientific) was added followed by benzoyl chloride (0.96 mL, 8.2 mmol, purchased from Fisher Scientific). Once the reaction was complete it was diluted with water, and the organic layer removed. The aqueous layer was then washed with dichloromethane twice and the organic material combined. The organic material was dried with sodium sulfate, filtered, and concentrated. Purification using a Teledyne ISCO on silica support (hexanes/ethyl acetate gradient) afforded the desired 1-benzoyl-1H-indol-3-yl)methyl benzoate. 42% yield. 1H-NMR delta8.42 (d, 1H), 8.02 (dd, 2H), 7.76 (m, 3H), 7.62 (dd, 1H), 7.54 (m, 3H), 7.47-7.37 (m, 5H), 5.50 (s, 2H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
43.7% | With sodium; In water; toluene; at 100℃; for 9h; | To a mixture of 1.18g (0.01mol) of 7-azaindole in toluene (80ml) 1.47g (0.01mol) of 3-hydroxymethylindole was added and heated to boiling point, then 0.1g (0.0043mol) of Na was added. (If the reaction mixture was cloudy after heating, the azeotrope toluene-water was distilled before adding Na.) The reaction was continued for 9h at toluene's boiling point temperature with simultaneous distilling of secreting water. Next 3ml of methanol was added. To the cooled mixture 50ml of water was added and left for several hours at 4C. The obtained crude solid was separated yielding 1.52g (61.5%). After crystallization from ethanol/water (3:2) 1.08g of beige crystals was obtained (yield 43.7%). M.p. 164.0-164.3C. - IR (nujol): nu=3380 (N-H), 3100-3000, 3000-2800, 1630, 1600, 1480, 1420, 1330 (C-N) cm-1. 1H NMR (299.87MHz, DMSO-d6): delta=4.159 (s, 2H, 10-H), 6.916 (t, J1=1.2MHz, J2=7.2Hz, 1H, 6-H), 7.031 (t, J1=1.2Hz, J2=7.2Hz, 1H, 7-H), 7.108 (dd, J1=7.8Hz, J2=5.1Hz, 1H, 6?-H), 7.187 (s, J=3.2Hz, 1H, 2-H), 7.316 (d, J1=0.9Hz, J2=7.8Hz, 1H, 8-H), 7.377 (bs, 1H, 2?-H), 7.510 (dd, J1=1Hz, J2=7.8Hz, 1H, 5-H), 8.096 (d, J1=7.8Hz, J2=0.9Hz, 1H, 5?-H), 8.227 (t, J1=1.5Hz, J2=5.1Hz, 1H, 6?H), 10.758 (s, 1H, 1-NH), 11.649 (s, 1H, 1?-NH). 13C NMR (75.40MHz, DMSO-d6): delta=20.66 (10-C), 111.39 (8-C), 113.15 (3-C), 114.57 (3?-C), 114.71 (6?-C), 118.16 (6-C), 118.51 (5-C), 120.87 (7-C), 122.03 (4?-C), 122.98 (2-C), 124.80 (2?-C), 126.94 (4?-C), 130.96 (5?-C), 136.38 (9-C), 138.05 (7?-C) ppm. C16H13N3 (247.29): calcd. C 77.71, H 5.30, N 16.99: found C 77.70, H 5.38, N 16.94. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
13.8% | With sodium; In water; toluene; at 100℃; for 11h; | 3-Hydroxymethyl indole (1.47g, 0.01mol) was added to a suspension of indazole (1.18g, 0.01mol) in anhydrous toluene (130ml). The mixture was heated at the solvent's boiling temperature. To the mixture (0.05g, 0.0022mol) Na was added. (If the reaction mixture was cloudy after heating, the azeotrope toluene-water was distilled before adding Na.) The heating at boiling temperature was continued for 11h. The secreted water was removed. After this time, 3ml of ethanol was added and the mixture was heated for the next 1h. Then the mixture was kept at 4C for 24h. The obtained yellow solid was filtered and crystallized from ethanol/water (7:10 v/v) yielding 0.34g (13.8%) of beige crystals. M.p. 176.1-176.8C. - IR (nujol): nu=3160 (N-H), 3100-3000, 3000-2800, 1630, 1560, 1480, 1420, 1330 (C-N) cm-1. 1H NMR (299.87MHz, DMSO-d6): delta=5.768 (s, 2H 10-H), 6.924 (t, J=7.5Hz, 1H, 6-H), 7.036 (t, J=7.5Hz, 1H, 7-H), 7.085 (t, J=7.5Hz, 1H, 6?-H), 7.323 (d, J=8.0Hz, 1H, 8?-H), 7.336 (t, J=7.7Hz, 1H, 7?-H), 7.523 (d, J=1.8Hz, 1H, 2-H), 7.558 (d, J=8.0Hz, 1H, 5-H) 7.738 (d, J=8.3Hz,1H, 5?-H), 7.783 (d, J=8.3Hz, 1H, 8?-H), 8.046 (s, 1H, 3?-H), 11.026 (bs, 1H, N-H). 13C NMR (75.40MHz, DMSO-d6): delta=44.47 (10-C), 110.00 (8?-C), 110.53 (3-C), 111.44 (8-C), 118.71 (6-C), 118.78 (5-C), 120.17 (6?-C), 120.74 (5?-C), 121.21 (7-C), 123.75 (4?-C), 124.80 (2-C), 125.67 (7?-C), 126.36 (4-C), 132.05 (3?C), 136.25 (9-C),138.70 (9-C) ppm. C16H13N3 (247.29): calcd. C 77.71, H 5.30, N 16.99: found C 77.70, H 5.28, N 16.88. |
Tags: 700-06-1 synthesis path| 700-06-1 SDS| 700-06-1 COA| 700-06-1 purity| 700-06-1 application| 700-06-1 NMR| 700-06-1 COA| 700-06-1 structure
[ 14384-34-0 ]
2,3,4,9-Tetrahydro-1H-carbazol-3-ol
Similarity: 0.77
[ 151358-47-3 ]
4-(Di(1H-indol-3-yl)methyl)phenol
Similarity: 0.77
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P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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