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Chemical Structure| 700871-86-9 Chemical Structure| 700871-86-9

Structure of 700871-86-9

Chemical Structure| 700871-86-9

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Product Details of [ 700871-86-9 ]

CAS No. :700871-86-9
Formula : C10H5BrF3NO3S
M.W : 356.12
SMILES Code : O=S(C(F)(F)F)(OC1=CC=NC2=CC(Br)=CC=C12)=O

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Application In Synthesis of [ 700871-86-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 700871-86-9 ]

[ 700871-86-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 700871-86-9 ]
  • [ 4540-87-8 ]
  • benzyl N-[2-(7-bromoquinolin-4-yl)ethyl]carbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
43.14% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In water; toluene; at 70.0℃; for 16.0h;Inert atmosphere; In a 500-nil 3-necked round-bottom flask purged and maintained with an inertatmosphere of nitrogen was placed 7-bromoquinolin-4-yl trifluoromethanesulfonate (7.5g, 21.06 mmol, 1 equiv), C52CO3 (20585.8 mg, 63.18 mmol, 3.0 equiv), (2- [[(benzyloxy)carbonyljaminojethyl)boronic acid (9394.4 mg, 42.12 mmol, 2 equiv), and Pd(dppf)C12 (1541.0 mg, 2.11 mmol, 0.1 equiv) in toluene (200 mL) and H20 (50 mL). The resulting solution was stirred for 16 hours at 70 C. The resulting mixture was cooled to room temperature and concentrated. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1:1). This resulted in 3.5 g (43.14%) of benzyl N-[2- (7-bromoquinolin-4-yl)ethyljcarbamate as a white solid. LC-MS: [M+Hj = 385.0.
 

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