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Chemical Structure| 70093-12-8 Chemical Structure| 70093-12-8

Structure of 70093-12-8

Chemical Structure| 70093-12-8

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Product Details of [ 70093-12-8 ]

CAS No. :70093-12-8
Formula : C15H10FNO
M.W : 239.24
SMILES Code : FC1=CC=C(C=C1)C1=C(C=O)C2=C(N1)C=CC=C2
MDL No. :MFCD00278629

Safety of [ 70093-12-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H332
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501

Application In Synthesis of [ 70093-12-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 70093-12-8 ]

[ 70093-12-8 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 70093-12-8 ]
  • [ 16732-66-4 ]
  • 3-[(2-(2-bromophenyl)hydrazono)methyl]-2-(4-fluorophenyl)-1H-indole [ No CAS ]
YieldReaction ConditionsOperation in experiment
52.5% In ethanol; for 0.5h;Heating; General procedure: 2-(p-Fluorophenyl)-1H-indole-3-carboxaldehyde (1 mmol) andphenyl hydrazine or its derivatives (1.3 mmol) in EtOH (20 mL)were heated for 30 min on a hot water bath. On cooling, the formedprecipitate was collected, washed with cold EtOH, and recrystallizedfrom water to give compounds with 5.0-69.3% yield. 3-[(2-(2-Bromophenyl)hydrazono)methyl]-2-(4-fluorophenyl)-1H-indole (1h): Yield 52.5%. Mp 160-164 C. FT-IR (KBr): v = 1590 (C=N, azomethine stretch), 3388 cm-1 (N-H stretch). 1H NMR (DMSO-d6): delta = 6.66-6.70 (1H, m), 7.19-7.26 (2H, m), 7.34-7.48 (5H, m), 7.53-7.56 (1H, dd, Jm = 1.2 Hz, Jo = 8.4 Hz), 7.71-7.75 (2H, m), 8.35-8.37 (1H, dd, Jo = 6.4 Hz, Jm = 1.6 Hz) 8.64 (1H, s, hydrazine-NH), 9.40 (1H, s, azomethine-CH), 11.73 (1H, s, indole-H). 13C NMR: delta = 106.14, 109.59, 112.13, 114.24, 116.5, 119.77, 121.31, 122.67, 123.50, 126.09, 128.75, 129.37, 131.90, 133.20, 137.16, 139.17, 143.73, 161.61, 164.06. ESI-MS: m/z = 408.7 [M+1] (95%), 410.7 [M+1+2] (100%). C21H15N3BrF: calcd. C 61.90, H 3.71, N 10.32; found C 61.59, H 3.67, N 10.13.
  • 2
  • [ 70093-12-8 ]
  • [ 658-27-5 ]
  • 2-(4-fluorophenyl)-3-[(2-(3-fluorophenyl)hydrazono)methyl]-1H-indole [ No CAS ]
YieldReaction ConditionsOperation in experiment
45.0% In ethanol; for 0.5h;Heating; General procedure: 2-(p-Fluorophenyl)-1H-indole-3-carboxaldehyde (1 mmol) andphenyl hydrazine or its derivatives (1.3 mmol) in EtOH (20 mL)were heated for 30 min on a hot water bath. On cooling, the formedprecipitate was collected, washed with cold EtOH, and recrystallizedfrom water to give compounds with 5.0-69.3% yield. 2-(4-Fluorophenyl)-3-[(2-(3-fluorophenyl)hydrazono)methyl]-1H-indole (1k): Yield 45.0%. Mp 140-144 C. FT-IR (KBr): v = 1610 (C=N, azomethine stretch), 3400 cm-1 (N-H stretch). 1H NMR (DMSO-d6): delta = 6.44-6.49 (1H, m), 6.76-6.80(2H, m), 7.19-7.26 (3H, m), 7.42-7.47 (3H, m), 7.69-7.73 (2H, m), 8.20 (1H, s, hydrazine-NH), 8.31-8.33 (1H, m), 10.19 (1H, s, azomethine-CH), 11.71 (1H, s, indole-H). ESI-MS: m/z = 348.8 [M+1] (100%). C21H15N3F2: calcd. C 72.59, H 4.36, N 12.10; found C 72.47, H 4.34, N 11.87.
  • 3
  • [ 70093-12-8 ]
  • [ 51516-70-2 ]
  • (E)-1-(4-fluorophenyl)-5-(((2-(4-fluorophenyl)-1H-indol-3-yl)methylene)amino)-1H-pyrazole-4-carbonitrile [ No CAS ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; In ethanol; water; at 80℃; General procedure: Intermediate 4 (1mmol) and the intermediate 7 (1mmol) were dissolved in ethanol to the glass flask, then HCl solution was added as a catalyst refluxed at 80C for 15-18h. After the TLC monitoring reaction was completed, the mixture was vacuum filtered and concentrated. Finally, the above crude product can be isolated and purified by column chromatography (Hexane/EtOAc=8:1) to obtain target compounds.
 

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