70199-60-9|4-(Methoxymethyl)pyridine| Ambeed

CAS No. :	70199-60-9
Formula :	C₇H₉NO
M.W :	123.15
SMILES Code :	COCC1=CC=NC=C1
MDL No. :	MFCD13175366
InChI Key :	MBGSSZLPFNHEHX-UHFFFAOYSA-N
Pubchem ID :	642837

Safety of [ 70199-60-9 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 70199-60-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 70199-60-9 ]

[ 70199-60-9 ] Synthesis Path-Downstream 1~48

1
[ 124-41-4 ]
[ 1822-51-1 ]
[ 70199-60-9 ]

References: [1]Journal of the American Chemical Society,2018,vol. 140,p. 3322 - 3330.
[2]Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan,1959,vol. 79,p. 1277,1280.
Chem.Abstr.,1960,p. 4566.
[3]Advanced Synthesis and Catalysis,2017,vol. 359,p. 1927 - 1932.

2
[ 872-85-5 ]
[ 67-56-1 ]
[ 70199-60-9 ]

References: [1]Synthesis,1982,p. 419 - 421.

3
[ 70199-60-9 ]
C₇H₈NO^(1-)*Li⁽¹⁺⁾ [ No CAS ]

References: [1]Synthesis,1991,p. 1221 - 1227.

4
[ 1007-48-3 ]
[ 74-88-4 ]
[ 70199-60-9 ]

References: [1]Chemistry of Heterocyclic Compounds,1998,vol. 34,p. 40 - 43.

6
[ 70199-60-9 ]
[ 6068-28-6 ]
1-hexadecyl-4-(methoxymethyl)pyridinium tosylate [ No CAS ]

References: [1]European Journal of Medicinal Chemistry,2005,vol. 40,p. 840 - 849.

7
[ 70199-60-9 ]
[ 143-15-7 ]
1-dodecyl-4-methoxymethyl-pyridinium; bromide [ No CAS ]

References: [1]European Journal of Medicinal Chemistry,2005,vol. 40,p. 840 - 849.

8
[ 586-95-8 ]
[ 70199-60-9 ]

References: [1]Chemistry of Heterocyclic Compounds,1998,vol. 34,p. 40 - 43.

9
[ 70199-60-9 ]
[ 138761-48-5 ]

References: [1]Synthesis,1991,p. 1221 - 1227.

10
[ 70199-60-9 ]
[ 138761-47-4 ]

References: [1]Synthesis,1991,p. 1221 - 1227.

11
[ 70199-60-9 ]
[ 74-88-4 ]
4-methoxymethyl-1-methyl-1,2,3,6-tetrahydropyridine [ No CAS ]
4-methoxymethyl-1-methyl-pyridinium iodide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In acetonitrile;	a) 4-Methoxymethyl-1-methyl-pyridinium iodide A solution of 4.8 g (0.039 mol) of 4-methoxymethyl-pyridine in 25 ml of acetonitrile is mixed with 6.6 g (0.047 mol) of methyl iodide and stirred for 5 hours at ambient temperature. Then the partially precipitated quaternary salt is precipitated by the addition of ethyl acetate. 9.1 g (88% of theory) of 4-methoxymethyl-1-methyl-pyridinium iodide are obtained, m.p. 105-108 C. The analytically pure methoiodide has a melting point of 106-108 C. (CH3 CN). [C8 H12 NO]+ I- (265.10). Calculated: C 36.25; H 4.57; H 5.28; I 47.87; Found: 36.02, 4.60, 5.26, 47.69.

References: [1]Patent: US5422353,1995,A .

12
[ 70199-60-9 ]
[ 1225380-68-6 ]
[ 1227159-73-0 ]

Yield	Reaction Conditions	Operation in experiment
	In methanol; at 160.0℃; for 3.0h;Microwave irradiation;	Example 149 2-[4-(Methoxymethyl)piperidin-1-yl]-4-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxa-diazol-5-yl}-1H-pyrazol-1-yl)methyl]pyridine 445 mg (3.44 mmol) of <strong>[70199-60-9]4-(methoxymethyl)pyridine</strong> and 100 mg (0.229 mmol) of the compound from Example 81A were heated at 160 C. in a microwave oven (Biotage Initiator 2.5, automatic control of the irradiation power) for 3 h without addition of a solvent. After cooling to RT, the reaction mixture was taken up in approx. 2 ml of methanol. This solution was separated directly into its components by means of preparative HPLC (method N). The product fractions were combined and freed from the solvent and the residue was stirred with pentane. 77 mg (60% of th., purity of approx. 94%) of the title compound were obtained. 1H-NMR (400 MHz, CDCl3, δ/ppm): 8.25 (d, 2H), 8.11 (d, 1H), 7.33 (d, 2H), 6.83 (s, 1H), 6.35 (s, 1H), 6.29 (d, 1H), 5.33 (s, 2H), 4.26-4.20 (m, 2H), 3.33 (s, 3H), 3.23 (d, 2H), 2.83-2.77 (m, 2H), 2.29 (s, 3H), 1.88-1.77 (m, 3H), 1.29-1.18 (m, 2H). LC/MS (method I, ESIpos): Rt=1.09 min, m/z=529 [M+H]+.

References: [1]Patent: US2013/196964,2013,A1 .Location in patent: Paragraph 1949; 1950; 1951; 1952.

13
[ 70199-60-9 ]
[ 557-93-7 ]
4-(1-methoxy-2-methylallyl)pyridine [ No CAS ]

References: [1]Organic Letters,2016,vol. 18,p. 2371 - 2374.

14
[ 70199-60-9 ]
[ 3017-70-7 ]
4-(1-methoxy-2,3-dimethylbut-2-enyl)pyridine [ No CAS ]