Alternatived Products of [ 70590-48-6 ]
Product Details of [ 70590-48-6 ]
CAS No. : | 70590-48-6 |
MDL No. : | MFCD18819543 |
Formula : |
C7H7NOS
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
153.20
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 70590-48-6 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 70590-48-6 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 70590-48-6 ]
- 1
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[ 36234-66-9 ]
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[ 70590-48-6 ]
Yield | Reaction Conditions | Operation in experiment |
52% |
With isopentyl nitrite; In tetrahydrofuran; at 0 - 45℃; for 3.0h; |
Int-36 (1.0 g, 5.95 mmol) was dissolved in tetrahydrofuran (20 mL) and isoamyl nitrite (0.95 mL, 7.14 mmol) was added at 0 °C. Then the mixture was heated at 45 °C for 3 h. After cooling to rt, the mixture was quenched with aq. ammonium chloride and extracted with EtOAc (3 x 50 mL). The combined organic layers were washed with water (30 mL), brine (30 mL), dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude product was purified by colunm chromatography on neutral alumina using 5percent EtOAc in hexane as eluent. 6,7- Dihydrobenzo[d]thiazol-4(5H)-one (int-37) was obtained as an off-white solid in 52percent (480 mg) yield. ?H-NMR (400 MHz, DMSO-d6): oe 8.95 (s, 1H), 3.13 (t, J= 6.0 Hz, 2H), 2.60-2.53 (m, 2H), 2.13 (dt, J= 12.4, 6.4 Hz, 2H); MS (ESI) mlz 154.13 [M+Hj. |