[ CAS No. 70705-30-5 ] {[proInfo.proName]}

Name: 70705-30-5|Ethyl 6-methylimidazo[1,2-a]pyridine-2-carboxylate|98%
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SKU: A892325
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Quality Control of [ 70705-30-5 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

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Product Details of [ 70705-30-5 ]

CAS No. :	70705-30-5	MDL No. :	MFCD02325396
Formula :	C₁₁H₁₂N₂O₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	BFYXMAOPTOBSJZ-UHFFFAOYSA-N
M.W :	204.23	Pubchem ID :	12558372
Synonyms :

Calculated chemistry of [ 70705-30-5 ] Expand+

Physicochemical Properties

Num. heavy atoms :	15
Num. arom. heavy atoms :	9
Fraction Csp3 :	0.27
Num. rotatable bonds :	3
Num. H-bond acceptors :	3.0
Num. H-bond donors :	0.0
Molar Refractivity :	56.24
TPSA :	43.6 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	Yes
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.64 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.64
Log Po/w (XLOGP3) :	2.68
Log Po/w (WLOGP) :	1.82
Log Po/w (MLOGP) :	1.23
Log Po/w (SILICOS-IT) :	1.57
Consensus Log Po/w :	1.99

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-3.04
Solubility :	0.186 mg/ml ; 0.000911 mol/l
Class :	Soluble
Log S (Ali) :	-3.25
Solubility :	0.115 mg/ml ; 0.000565 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-2.96
Solubility :	0.224 mg/ml ; 0.0011 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	2.03

Safety of [ 70705-30-5 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 70705-30-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 70705-30-5 ]

[ 70705-30-5 ] Synthesis Path-Downstream 1~24

1
[ 72721-17-6 ]
[ 70705-30-5 ]

Yield	Reaction Conditions	Operation in experiment
30%	With hydrazine hydrate In ethanol for 0.166667h; Heating;

Reference： [1]Rees, Charles W.; Smith, David I. [Journal of the Chemical Society. Perkin transactions I, 1987, p. 1159 - 1164]

2
[ 70705-30-5 ]
[ 132272-63-0 ]

Yield	Reaction Conditions	Operation in experiment
69%	With acetic anhydride; acetic acid; nitrosylchloride at -10 - -5℃;

Reference： [1]Gueiffier; Milhavet; Blache; Chavignon; Teulade; Madesclaire; Viols; Dauphin; Chapat [Chemical and Pharmaceutical Bulletin, 1990, vol. 38, # 9, p. 2352 - 2356]

3
[ 70705-30-5 ]
6-methylimidazo<1,2-a>pyridine-2-carboxylic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
50%	With hydrogenchloride for 3h; Heating;

Reference： [1]Abignente; Arena; de Caprariis; Ferreri; Marmo; Ottavo; Rossi; Giasi [Farmaco, Edizione Scientifica, 1981, vol. 36, # 10, p. 893 - 904]

4
[ 70705-30-5 ]
[ 72721-16-5 ]

Yield	Reaction Conditions	Operation in experiment
80%	With nitric acid for 3h;
70%	With sulfuric acid; nitric acid at 0 - 5℃; for 3h; Inert atmosphere;
	With sulfuric acid; nitric acid at -5 - 0℃; for 2h;

Reference： [1]Teulade, J. C.; Escale, R.; Rossi, J. C.; Chapat, J. P.; Grassy, G.; Payard, M. [Australian Journal of Chemistry, 1982, vol. 35, # 9, p. 1761 - 1768]
[2]Tber, Zahira; Biteau, Nicolas G.; Agrofoglio, Luigi; Cros, Julien; Goffinont, Stéphane; Castaing, Bertrand; Nicolas, Cyril; Roy, Vincent [European Journal of Organic Chemistry, 2019, vol. 2019, # 33, p. 5756 - 5767]
[3]Xia, Guangxin; Li, Jianfeng; Peng, Aiming; Lai, Shunan; Zhang, Shujun; Shen, Jingshan; Liu, Zhonghua; Chen, Xinjian; Ji, Ruyun [Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 11, p. 2790 - 2794]

Yield	Reaction Conditions	Operation in experiment
	Rk. mit HNO3, H2SO4 --> Nitroprodukte (9) u. (10);

Yield	Reaction Conditions	Operation in experiment
93%	In 1,2-dimethoxyethane at 20℃; for 0.75h;	8.A General procedure: [001202] Step A: To a solution of 2-amino-5-methylpyrazine (1.09 g, 10 mmol) in DME (10 mL) was added ethyl 3-bromo-2-oxopropanoate (1.57 mL, 12.5 mmol). The mixture was stirred at room temperature for 45 minutes. The precipitate was filtered, washed with Et20 and dried to give a yellow solid. The solid was suspended in EtOH (20 mL) and heated at 90 °C. After 1.5 hours, the resulting brown solution was concentrated and adjusted to pH 7. The mixture was extracted with EtOAc. The organics were concentrated and the residue was triturated and washed with MeCN to give ethyl 6-methylimidazo[1,2-a]pyrazine-2-carboxylate as a brown solid (0.993 g, 48%).
	Brom-brenztraubensaeure-ethylester, 2-Amino-5-methyl-pyridin;
		27 Method O 6-Methyl-imidazo[1,2-a]pyridine-2-carboxylic acid and 6-methyl-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester were prepared in a similar manner to 6-fluoro-imidazo[1,2-a]pyridine-2-carboxylic acid and its ester above.

With sodium hydrogencarbonate In 1,4-dioxane at 100℃; for 12h;

Synthesis of Ethyl 6-bromoimidazo[l,2-a]pyridine-2-carboxylate(1-6) General procedure: To a stirred solution of 5-bromopyridin-2-amine(A14, 10 g, 57.8 mmol) in l,4-dioxane(120 mL) was added ethyl 3-bromo pyruvate(A15, 10.83 mL, 86.71 mmol), followed by NaHC03(9.71 g, 115.6 mmol). The reaction mixture was heated for 12 h at 100 °C and then concentrated under reduced pressure. The crude product was washed with ethyl acetate/water 2: 1 mixture(3x 75 mL) and the combined organic layer was concentrated. Purified by column chromatography using ethyl acetate/hexane to afford 16 as blackish brown solid(15.3 g, 98%). MS(ESI) m/z =271[M+H]+.

7
[ 1603-41-4 ]
[ 70-23-5 ]
[ 70705-30-5 ]

Yield	Reaction Conditions	Operation in experiment
60%	In 1,2-dimethoxyethane at 20℃; for 0.75h; Inert atmosphere;
	In ethanol for 6h; Heating;
	In ethanol at 20℃; for 38h; Heating / reflux;	334.a Step (a) Ethyl 6-methylimidazo[l,2-a]ρyridine-2-carboxylateEthyl bromopyruvate (10.04 g, 55.48 mmol) was added slowly to 5-methylpyridin-2-amine (4 g, 36.99 mmol) in ethanol (60 ml) at ambient temperature. The reaction mixture was stirred at reflux for 19 h. Ethyl bromopyruvate (2.321 ml, 18.49 mmol) was added and the reaction mixture was refluxed for a further 19 h. The solvents were evaporated and IN HCl (100 mL) was added to the residue. The aqueous layer was washed with ethyl acetate, basified with aq. saturated sodium bicarbonate solution, and the product extracted into ethyl acetate. The combined organic phase was washed with brine and dried over anhydrous sodium sulfate, filtered and evaporated. The crude residue was purified by flash silica chromatography, elution gradient 40% ethyl acetate in DCM. Pure fractions were evaporated to dryness to afford the sub-title compound as a yellow solid (1.1 g). 1H NMR (400 MHz, CDCl3) δ 8.09 (s, IH), 7.90 (d, IH), 7.57 (d, J = 9.2 Hz, IH), 7.09 (dd, IH), 4.45 (q, 2H)5 2.33 (d, 3H), 1.44 (t, 3H). [M+H]+=205

In ethanol for 1h; Reflux;

Reference： [1]Tber, Zahira; Biteau, Nicolas G.; Agrofoglio, Luigi; Cros, Julien; Goffinont, Stéphane; Castaing, Bertrand; Nicolas, Cyril; Roy, Vincent [European Journal of Organic Chemistry, 2019, vol. 2019, # 33, p. 5756 - 5767]
[2]Xia, Guangxin; Li, Jianfeng; Peng, Aiming; Lai, Shunan; Zhang, Shujun; Shen, Jingshan; Liu, Zhonghua; Chen, Xinjian; Ji, Ruyun [Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 11, p. 2790 - 2794]
[3]Current Patent Assignee: ALCON, INC. - WO2008/84223, 2008, A2 Location in patent: Page/Page column 423-424
[4]Feng, Song; Hong, Di; Wang, Baoxia; Zheng, Xiufang; Miao, Kun; Wang, Lisha; Yun, Hongying; Gao, Lu; Zhao, Shuhai; Shen, Hong C. [ACS Medicinal Chemistry Letters, 2015, vol. 6, # 3, p. 359 - 362]

8
[ 70705-30-5 ]
[ 859788-12-8 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: HNO₃; H₂SO₄ / 2 h / -5 - 0 °C 2: aq. NH₃ / tetrahydrofuran / 20 °C 3: H₂ / Pd/C / 50 °C
	Multi-step reaction with 3 steps 1: sulfuric acid; nitric acid / 3 h / 0 - 5 °C / Inert atmosphere 2: ammonium hydroxide / tetrahydrofuran; water / 20 h / 20 °C / Inert atmosphere; Sealed tube 3: tin(ll) chloride / ethanol / 0.17 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

Reference： [1]Xia, Guangxin; Li, Jianfeng; Peng, Aiming; Lai, Shunan; Zhang, Shujun; Shen, Jingshan; Liu, Zhonghua; Chen, Xinjian; Ji, Ruyun [Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 11, p. 2790 - 2794]
[2]Tber, Zahira; Biteau, Nicolas G.; Agrofoglio, Luigi; Cros, Julien; Goffinont, Stéphane; Castaing, Bertrand; Nicolas, Cyril; Roy, Vincent [European Journal of Organic Chemistry, 2019, vol. 2019, # 33, p. 5756 - 5767]

9
[ 70705-30-5 ]
[ 859787-82-9 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: HNO₃; H₂SO₄ / 2 h / -5 - 0 °C 2: aq. NH₃ / tetrahydrofuran / 20 °C
	Multi-step reaction with 2 steps 1: sulfuric acid; nitric acid / 3 h / 0 - 5 °C / Inert atmosphere 2: ammonium hydroxide / tetrahydrofuran; water / 20 h / 20 °C / Inert atmosphere; Sealed tube

10
[ 70705-30-5 ]
[ 859788-68-4 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1: HNO₃; H₂SO₄ / 2 h / -5 - 0 °C 2: aq. NH₃ / tetrahydrofuran / 20 °C 3: H₂ / Pd/C / 50 °C 4: pyridine; DMAP / CH₂Cl₂ 5: KOt-Bu / 2-methyl-propan-2-ol / Heating

11
[ 70705-30-5 ]
[ 859788-42-4 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: HNO₃; H₂SO₄ / 2 h / -5 - 0 °C 2: aq. NH₃ / tetrahydrofuran / 20 °C 3: H₂ / Pd/C / 50 °C 4: pyridine; DMAP / CH₂Cl₂

12
[ 70705-30-5 ]
4-ethoxy-3-(6-methyl-1-oxo-1,2-dihydro-2,4,4b,9-tetraaza-fluoren-3-yl)-benzenesulfonyl chloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 6 steps 1: HNO₃; H₂SO₄ / 2 h / -5 - 0 °C 2: aq. NH₃ / tetrahydrofuran / 20 °C 3: H₂ / Pd/C / 50 °C 4: pyridine; DMAP / CH₂Cl₂ 5: KOt-Bu / 2-methyl-propan-2-ol / Heating 6: chlorosulfonic acid / 3 h / 0 - 5 °C

13
[ 70705-30-5 ]
3-[2-ethoxy-5-(4-methyl-piperazine-1-sulfonyl)-phenyl]-6-methyl-2<i>H</i>-2,4,4b,9-tetraaza-fluoren-1-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 7 steps 1: HNO₃; H₂SO₄ / 2 h / -5 - 0 °C 2: aq. NH₃ / tetrahydrofuran / 20 °C 3: H₂ / Pd/C / 50 °C 4: pyridine; DMAP / CH₂Cl₂ 5: KOt-Bu / 2-methyl-propan-2-ol / Heating 6: chlorosulfonic acid / 3 h / 0 - 5 °C 7: Et₃N / CHCl₃ / 20 °C

14
[ 70705-30-5 ]
[ 926223-25-8 ]

Yield	Reaction Conditions	Operation in experiment
	Stage #1: ethyl 6-methylimidazo<1,2-a>pyridine-2-carboxylate With lithium aluminium tetrahydride In tetrahydrofuran at 5℃; for 1h; Stage #2: With ethyl acetate In tetrahydrofuran Stage #3: With water In tetrahydrofuran; dichloromethane; ethyl acetate	334.b Step (b) 6-Methylimidazo[l,2-a]pyridin-2-yl)methanolA solution of ethyl 6-methylimidazo[l,2-a]pyridine-2-carboxylate (1.11 g, 5.44 mmol) in tetrahydrofuran (20 mL) was added dropwise to lithium aluminium hydride (IM in THF)(5.44 mL, 5.44 mmol) at 5 0C and the reaction mixture was stirred at 5 0C for 1 h. The reaction was quenched by dropwise addition of ethyl acetate. After allowing to warm to room temperature, the mixture was partitioned between DCM and water. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated to afford the sub- title compound as a pale brown solid (0.84 g).1H NMR (400 MHz, CDCl3) δ 7.87 (s, IH), 7.47 - 7.44 (m, 2H), 7.02 (dd, J = 9.1, 1.2 Hz,IH), 4.82 (s, 2H), 2.31 (s, 3H).[M+H]+=163
	With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 1h;

Reference： [1]Current Patent Assignee: ALCON, INC. - WO2008/84223, 2008, A2 Location in patent: Page/Page column 424
[2]Feng, Song; Hong, Di; Wang, Baoxia; Zheng, Xiufang; Miao, Kun; Wang, Lisha; Yun, Hongying; Gao, Lu; Zhao, Shuhai; Shen, Hong C. [ACS Medicinal Chemistry Letters, 2015, vol. 6, # 3, p. 359 - 362]

15
[ 70705-30-5 ]
C₁₈H₁₆BrN₅O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C 2: N-Bromosuccinimide / acetonitrile / 0 °C 3: thionyl chloride / dichloromethane / 2 h / 20 °C 4: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C

Reference： [1]Feng, Song; Hong, Di; Wang, Baoxia; Zheng, Xiufang; Miao, Kun; Wang, Lisha; Yun, Hongying; Gao, Lu; Zhao, Shuhai; Shen, Hong C. [ACS Medicinal Chemistry Letters, 2015, vol. 6, # 3, p. 359 - 362]

16
[ 70705-30-5 ]
C₂₈H₃₅N₅O₂Si [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C 2: N-Bromosuccinimide / acetonitrile / 0 °C 3: thionyl chloride / dichloromethane / 2 h / 20 °C 4: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C 5: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / acetonitrile / 0.5 h / Microwave irradiation; Heating; Inert atmosphere

17
[ 70705-30-5 ]
C₂₂H₂₁N₅O₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 6 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C 2: N-Bromosuccinimide / acetonitrile / 0 °C 3: thionyl chloride / dichloromethane / 2 h / 20 °C 4: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C 5: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / acetonitrile / 0.5 h / Microwave irradiation; Heating; Inert atmosphere 6: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C

18
[ 70705-30-5 ]
C₂₂H₂₅N₅O₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 7 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C 2: N-Bromosuccinimide / acetonitrile / 0 °C 3: thionyl chloride / dichloromethane / 2 h / 20 °C 4: sodium hydride / N,N-dimethyl-formamide / 0 - 20 °C 5: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / acetonitrile / 0.5 h / Microwave irradiation; Heating; Inert atmosphere 6: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C 7: palladium 10% on activated carbon; hydrogen / 3 h / 20 °C

19
[ 70705-30-5 ]
C₉H₉BrN₂O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C 2: N-Bromosuccinimide / acetonitrile / 0 °C

20
[ 70705-30-5 ]
C₉H₈BrClN₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C 2: N-Bromosuccinimide / acetonitrile / 0 °C 3: thionyl chloride / dichloromethane / 2 h / 20 °C

21
[ 70705-30-5 ]
8-methyl-4-(p-tolyl)-2-(trifluoromethyl)pyrido[1,2-e]purine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 6 steps 1: sulfuric acid; nitric acid / 3 h / 0 - 5 °C / Inert atmosphere 2: ammonium hydroxide / tetrahydrofuran; water / 20 h / 20 °C / Inert atmosphere; Sealed tube 3: tin(ll) chloride / ethanol / 0.17 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation 4: 24 h / 110 - 160 °C / Inert atmosphere 5: thionyl chloride / chloroform; N,N-dimethyl-formamide / 1.5 h / Inert atmosphere; Reflux 6: potassium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 0.5 h / 120 °C / Inert atmosphere; Sealed tube; Microwave irradiation

22
[ 70705-30-5 ]
8-methyl-4-(4-(trifluoromethoxy)phenyl)-2-(trifluoromethyl)-pyrido[1,2-e]purine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 6 steps 1: sulfuric acid; nitric acid / 3 h / 0 - 5 °C / Inert atmosphere 2: ammonium hydroxide / tetrahydrofuran; water / 20 h / 20 °C / Inert atmosphere; Sealed tube 3: tin(ll) chloride / ethanol / 0.17 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation 4: 24 h / 110 - 160 °C / Inert atmosphere 5: thionyl chloride / chloroform; N,N-dimethyl-formamide / 1.5 h / Inert atmosphere; Reflux 6: potassium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / toluene / 0.5 h / 120 °C / Inert atmosphere; Sealed tube; Microwave irradiation

23
[ 70705-30-5 ]
8-methyl-2-(trifluoromethyl)pyrido[1,2-e]purin-4-ol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: sulfuric acid; nitric acid / 3 h / 0 - 5 °C / Inert atmosphere 2: ammonium hydroxide / tetrahydrofuran; water / 20 h / 20 °C / Inert atmosphere; Sealed tube 3: tin(ll) chloride / ethanol / 0.17 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation 4: 24 h / 110 - 160 °C / Inert atmosphere

24
[ 70705-30-5 ]
4-chloro-8-methyl-2-(trifluoromethyl)pyrido[1,2-e]purine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1: sulfuric acid; nitric acid / 3 h / 0 - 5 °C / Inert atmosphere 2: ammonium hydroxide / tetrahydrofuran; water / 20 h / 20 °C / Inert atmosphere; Sealed tube 3: tin(ll) chloride / ethanol / 0.17 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation 4: 24 h / 110 - 160 °C / Inert atmosphere 5: thionyl chloride / chloroform; N,N-dimethyl-formamide / 1.5 h / Inert atmosphere; Reflux

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P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 70705-30-5 ] {[proInfo.proName]}

Quality Control of [ 70705-30-5 ]

Related Doc. of [ 70705-30-5 ]

Product Details of [ 70705-30-5 ]

Calculated chemistry of [ 70705-30-5 ] Expand+

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 70705-30-5 ]

Application In Synthesis of [ 70705-30-5 ]

[ 70705-30-5 ] Synthesis Path-Downstream 1~24

Related Functional Groups of [ 70705-30-5 ]

Esters

Related Parent Nucleus of [ 70705-30-5 ]

Other Aromatic Heterocycles

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

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[ 70705-30-5 ]

Related Parent Nucleus of
[ 70705-30-5 ]