Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 708-75-8 | MDL No. : | MFCD00012137 |
Formula : | C7H7N5O | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | UDOGNMDURIJYQC-UHFFFAOYSA-N |
M.W : | 177.16 | Pubchem ID : | 135416532 |
Synonyms : |
|
Signal Word: | Warning | Class: | |
Precautionary Statements: | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P313-P337+P313-P362-P403+P233-P405-P501 | UN#: | |
Hazard Statements: | H315-H319-H335 | Packing Group: | |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sulfuric acid unter Zutritt von Luft; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70% | With acetic acid at 140℃; | |
With acetic acid for 1.5h; Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With pyridine |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
bei der elektrochemischen Reduktion an einer Quecksilber-Kathode; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydroxide Hydrogenation; | ||
With hydrogen; benzenesulfonic acid In methanol at 70℃; for 15h; | C29 Example C29; 8.12 mg of [Rh(COD)2]BF4 (20 μmoles) and 15.57 mg of BINAP (25 μmoles) are weighed, degassed and dissolved in a mixture of tetrahydrofuran and methanol. The solvents are condensed off under a high vacuum and the residue is taken up in 5 ml of methanol. A suspension of 0.35 g of 6-methylpterin (2 mmoles) (prepared as per P. Waring et al., Aust. J. Chem. vol. 38, page 629, 1985) and 0.32 g of benzene sulphonic acid (2 mmoles) in 25 ml of methanol is added to the catalyst. The mixture is added in a nitrogen countercurrent to a 100 ml autoclave and hydrogenated at 70° C. and 80 bars hydrogen pressure for 15 hours. The conversion rate to 6-methyl-5,6,7,8-tetrahydropterin is 63% and is determined by HPLC direct from the reaction solution. The HPLC method employed is the same one as is used for the quantitative determination of the tetrahydrofolic acid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With formic acid; platinum Hydrogenation.und Behandeln des Reaktionsgemisches mit Acetanhydrid; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With water; hydrogen bromide; bromine |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
unter Ausschluss von Luft; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydroxide; water |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
at 280℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydroxide; zinc und anschliessend mit wss.H2O2; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
80% | With sodium hydrogensulfite; sodium sulfite In water at 0 - 20℃; for 13h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
78% | ||
40% | With dmap for 3h; Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
87% | With sodium dithionite; deuteriated sodium hydroxide In water-d2 at 22℃; for 48h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With deuterium In deuteromethanol; water-d2 at 22℃; for 48h; in neutral or weekly acidic media; | ||
With diclazuril; deuterium In deuteromethanol; water-d2 at 22℃; for 1h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium disulfite In water at 80℃; for 6h; further cyclizating agents; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With piperidine; potassium hydroxide 1.) water, 20 deg C, 7 d, 2.) heating; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
35 % Chromat. | With hydrogenchloride pH 3.0; Yields of byproduct given; | |
35 % Chromat. | With hydrogenchloride pH 3.0; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
1: 42% 2: 14% | With aluminum-mercury amalgam; ammonia In methanol; water for 10h; Ambient temperature; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Yield given. Multistep reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Rk. mit NaOD; | ||
Rk.MeJ,NaOH/MeOH:S.2024,2027;Rk.MeJ,MeOH:S.2025,2027; | ||
14C-Markierung: mechanist. Untersuch.; |
Rk. mit Trifluoressigsaeure u. Fluorsulfonsaeure -> Mono- u. Dikation: NMR-Spektren; | ||
In water at 20℃; Photolysis; | ||
With oxygen; rose bengal In water-d2 Irradiation; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Tetrahydropterin 1,O2; | ||
13a, KMnO4; | ||
Methylglyoxal, Pyrimidindihydrochlorid 1, Hydrazin.; |
Methylglyoxal-dihydrazon 18, 1-Dihydrochlorid; | ||
Acetamid II,Br2,Bisulfitsalz I; | ||
2,5,6-Triamino-4-hydroxypyrimidinium-sulfat; | ||
Pyrimidin II, N,N-Diacetylaminoaceton (IX), N2H4; | ||
Pyrimidin (III), CHOCOCH3 (IV), H2O (neben 7-Methylpterin <V>); | ||
2-Amino-4(3H)-oxo-5-phenyl-azo-pyrimidyl-amino-aceton-hydrochlorid, elektrolytische Reduktion; | ||
7,8-Dihydropterin,H2O2; | ||
/BRN= 125006//MeCOCH2NHCOMe/Hydrazin/AcOH; | ||
II + NH4OH + Pyruvaldehyd; | ||
(III), Luftoxidation, 0.1m Na- u. K-phosphat-Lsg.; | ||
V,Luftoxidation unter physiolog.Bed.; | ||
Reduktion von Folsaeure; | ||
Acetoxyaceton, 2,4,5-Triamino-6-oxo-dihydropyrimidin-dihydrochlorid; | ||
6-Methyl-7,8-dihydro-pterin, KMnO4; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
28% | for 0.0208333h; microwave irradiation; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
40% | for 0.0177778h; microwave irradiation; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70% | In water at 0 - 5℃; for 0.0172222h; microwave irradiation; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
71% | In N,N-dimethyl-formamide at 20℃; for 3.5h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
74% | In 1,4-dioxane for 3h; Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
62% | With perchloric acid at 70 - 80℃; for 0.25h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: 71 percent / dimethylformamide / 3.5 h / 20 °C 2: 81 percent / Ph3P; diisopropyl azodicarboxylate / dioxane / 24 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: 71 percent / dimethylformamide / 3.5 h / 20 °C 2: 79 percent / Ph3P; diisopropyl azodicarboxylate / dioxane / 24 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: 71 percent / dimethylformamide / 3.5 h / 20 °C 2: 81 percent / Ph3P; diisopropyl azodicarboxylate / dioxane / 24 h / 20 °C 3: 71 percent / conc. aq. NH3 / methanol / 24 h / 20 °C | ||
Multi-step reaction with 2 steps 1: 74 percent / dioxane / 3 h / Heating 2: 71 percent / conc. aq. NH3 / methanol / 24 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: 87 percent / Na2S2O4, NaOD / D2O / 48 h / 22 °C 2: D2 / PtO2 / D2O; various solvent(s) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: 87 percent / Na2S2O4, NaOD / D2O / 48 h / 22 °C 2: D2 / PtO2 / D2O; various solvent(s) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1: 40 percent / 4-dimethylaminopyridine / 3 h / Heating 2: 44 percent / 4-chlorophenyl phosphorodichloridate, pyridine / 48 h / Ambient temperature 3: 96 percent / aq. NH3 / dioxane / 0.5 h / Ambient temperature 4: 89 percent / aq. NH3 / dioxane / 96 h / Ambient temperature |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: acetic acid / 1.5 h / Heating 2: 84 percent / acetic acid / 24 h / 85 - 90 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: acetic acid / 1.5 h / Heating 2: 84 percent / acetic acid / 24 h / 85 - 90 °C 3: 95 percent / 3M HCl / 16 h / Ambient temperature |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: 40 percent / 4-dimethylaminopyridine / 3 h / Heating 2: 44 percent / 4-chlorophenyl phosphorodichloridate, pyridine / 48 h / Ambient temperature 3: 96 percent / aq. NH3 / dioxane / 0.5 h / Ambient temperature |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: 40 percent / 4-dimethylaminopyridine / 3 h / Heating 2: 44 percent / 4-chlorophenyl phosphorodichloridate, pyridine / 48 h / Ambient temperature |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 2: NBS, AcOH |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 2: NBS, AcOH |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 2: NBS, AcOH |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 2: NBS, AcOH |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 2: ozone / anschliessend Erwaermen mit wss. H2O2 in wss. HCl |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: aqueous pyridine 2: NaOH; water |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: aqueous pyridine 2: aqueous acetic acid |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
63% | Stage #1: In tetrahydrofuran; methanol Stage #2: 2-amino-6-methylpteridin-4(1H)-one; benzenesulfonic acid With hydrogen In methanl at 70℃; for 15h; | 29 Beispiel 29: 8,12 mg [Rh(COD)2]BF4 (20 umol) und 15,57 mg BINAP (25 umol) werden eingewogen, entgast und in einer Mischung aus Tetrahydrofuran und Methanol gelost. Die Losungsmittel werden im Hochvakuum abkondensiert und der Ruckstand in 5 ml Methanol aufgenommen. Zum Katalysator wird eine Suspension aus 0,35 g 6-Methylpterin (2 mmol) (hergestellt nach P. Waring et al., Aust. J. Chem., Bd. 38, Seite 629, 1985) und 0,32 g Benzolsulfonsaure (2 mmol) in 25 ml Methanol gegeben. Die Mischung wird im Stickstoffgegenstrom in einen 100 ml Autoklaven gegeben und bei 70oC und 80 bar Wasserstoffdruck 15 Stunden lang hydriert. Der Umsatz zu 6-Methyl-5,6,7,8-tetrahydropterin betragt 63% und wird mit HPLC direkt aus der Reaktionslosung bestimmt. Die verwendete HPLC-Methode ist die Gleiche, die fur die quantitative Bestimmung der Tetrahydrofolsaure verwendet wird. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With dihydrogen peroxide at 37℃; | ||
Ca. 50 %Chromat. | With oxygen In water at 25℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
57% | With pyridine for 4.5h; Reflux; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1: acetic acid / 140 °C 2: acetic acid; N-Bromosuccinimide; dibenzoyl peroxide / 3 h / 120 °C 3: calcium carbonate / N,N-dimethyl acetamide / 3 h / 95 °C / Inert atmosphere 4: tetrakis(actonitrile)copper(I) hexafluorophosphate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine / water; <i>tert</i>-butyl alcohol / 50 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: acetic acid / 140 °C 2: acetic acid; N-Bromosuccinimide; dibenzoyl peroxide / 3 h / 120 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: acetic acid / 140 °C 2: acetic acid; N-Bromosuccinimide; dibenzoyl peroxide / 3 h / 120 °C 3: calcium carbonate / N,N-dimethyl acetamide / 3 h / 95 °C / Inert atmosphere |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
62% | With dmap at 80℃; for 2h; | 1.2 Synthesis of N- (6-methyl-4-oxo-3,4-dihydropteridin-2-yl) isobutyramide (1-b) Isobutyric anhydride (10 mL) and N, N-dimethyl-4-aminopyridine (DMAP) (0.5 g) are added to a solution of compound (1-a) (4.71 g) in isobutyric acid (100 mL), and 80 ° C. Stir at for 2 hours and filter the clear solution. The filtrate was cooled to room temperature and left for 3 hours. The crystals were collected, washed with ethyl acetate and evaporated to dryness to give compound (1-b) (4.08 g, yield 62%) as a red solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
80% | Stage #1: 2,5,6-triamino-4-hydroxypyrimidine With sodium sulfite In water Stage #2: 2-oxopropanal With sodium hydrogensulfite In water at 5 - 20℃; | 1.1 Synthesis of 2-amino-6-methylpteridin-4 (3H) -one (1-a) Sodium sulfite (96.0 g) in a suspension of 3,5,6-triamino-4-hydroxypyrimidine (8 g) and water (800 mL)Was added and stirred. It was cooled to 0-5 ° C. when the mixture became a clear solution.A 30% aqueous solution of 2-oxopropanal (8 g) and a solution of sodium bisulfite (3.8 g) and water (80 mL) were added dropwise over 40 minutes and kept at 5 ° C. The mixture was stirred at room temperature overnight. The yellow solid is collected by filtration, washed with water, ethanol and evaporated to dryness under reduced pressure as a yellow solid4.72 g (yield 80%) of 2-amino-6-methylpteridin-4 (3H) -one (1-a) were obtained. |
[ 712-30-1 ]
2-Amino-4-oxo-3,4-dihydropteridine-6-carbaldehyde
Similarity: 1.00
[ 59212-10-1 ]
2-Amino-6-(bromomethyl)pteridin-4(3H)-one hydrobromide
Similarity: 0.92
[ 948-60-7 ]
2-Amino-4-oxo-3,4-dihydropteridine-6-carboxylic acid
Similarity: 0.91
[ 712-30-1 ]
2-Amino-4-oxo-3,4-dihydropteridine-6-carbaldehyde
Similarity: 1.00
[ 59212-10-1 ]
2-Amino-6-(bromomethyl)pteridin-4(3H)-one hydrobromide
Similarity: 0.92
[ 712-30-1 ]
2-Amino-4-oxo-3,4-dihydropteridine-6-carbaldehyde
Similarity: 1.00
[ 59212-10-1 ]
2-Amino-6-(bromomethyl)pteridin-4(3H)-one hydrobromide
Similarity: 0.92
[ 948-60-7 ]
2-Amino-4-oxo-3,4-dihydropteridine-6-carboxylic acid
Similarity: 0.91
[ 712-30-1 ]
2-Amino-4-oxo-3,4-dihydropteridine-6-carbaldehyde
Similarity: 1.00
[ 59212-10-1 ]
2-Amino-6-(bromomethyl)pteridin-4(3H)-one hydrobromide
Similarity: 0.92
[ 712-30-1 ]
2-Amino-4-oxo-3,4-dihydropteridine-6-carbaldehyde
Similarity: 1.00
[ 59212-10-1 ]
2-Amino-6-(bromomethyl)pteridin-4(3H)-one hydrobromide
Similarity: 0.92
[ 948-60-7 ]
2-Amino-4-oxo-3,4-dihydropteridine-6-carboxylic acid
Similarity: 0.91
[ 712-30-1 ]
2-Amino-4-oxo-3,4-dihydropteridine-6-carbaldehyde
Similarity: 1.00
[ 59212-10-1 ]
2-Amino-6-(bromomethyl)pteridin-4(3H)-one hydrobromide
Similarity: 0.92