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Chemical Structure| 70933-58-3 Chemical Structure| 70933-58-3

Structure of 70933-58-3

Chemical Structure| 70933-58-3

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Product Details of [ 70933-58-3 ]

CAS No. :70933-58-3
Formula : C10H9NO
M.W : 159.18
SMILES Code : CC(=O)NC1=CC(=CC=C1)C#C
MDL No. :MFCD00831583
InChI Key :KPCKMWGCLHYFCN-UHFFFAOYSA-N
Pubchem ID :2726447

Safety of [ 70933-58-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P264-P270-P301+P312+P330-P501

Application In Synthesis of [ 70933-58-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 70933-58-3 ]

[ 70933-58-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 70933-58-3 ]
  • [ 5459-50-7 ]
  • [ 1246471-71-5 ]
YieldReaction ConditionsOperation in experiment
With copper(l) iodide; triethylamine;bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 20℃;Inert atmosphere; 3-Ethynylacetanilide (480 mg, 3 mmol) and 2-iodo-5-introaniline (800 mg, 3 mmol) were dissolved in anhydrous THF (30 mL), PdCl2(PPh3)2 (105 mg,0.15 mmol) and CuI (28.5 mg,0.15 mmol) Et3N(I ml) was added sequentially. The reaction mixture was protected by N2 and stirred at RT for overnight. After that, the solvents were evaporated, and the residue was extracted with EtOAc (50x2 mL), washed with water (40 mL) and brine (30 mL), dried over anhydrous NaSO4. After concentrated in vacuo, the residue was purified by column chromatography (DCM/MeOH =50: l→20:l) to afford the desired product (620 mg). MS (ESI) m/e (M+H*): 296.
620 mg With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 25℃;Inert atmosphere; 3-Ethynylacetanilide (480 mg, 3 mmol) and 2-iodo-5-introaniline (800 mg, 3 mmol) were dissolved in anhydrous THF (30 mL), PdCl2(PPh3)2 (105 mg,0.15 mmol) and CuI (28.5 mg,0.15 mmol) Et3N (1 ml) was added sequentially. The reaction mixture was protected by N2 and stirred at RT for overnight. After that, the solvents were evaporated, and the residue was extracted with EtOAc (50×2 mL), washed with water (40 mL) and brine (30 mL), dried over anhydrous NaSO4. After concentrated in vacuo, the residue was purified by column chromatography (DCM/MeOH=50:1→20:1) to afford the desired product (620 mg). MS (ESI) m/e (M+H+): 296.
 

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