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Chemical Structure| 71041-12-8 Chemical Structure| 71041-12-8

Structure of 71041-12-8

Chemical Structure| 71041-12-8

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Product Details of [ 71041-12-8 ]

CAS No. :71041-12-8
Formula : C18H11Br2NO
M.W : 417.09
SMILES Code : BrC1=CC(OC2=CC(Br)=CC=C2N3C4=CC=CC=C4)=C3C=C1

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Application In Synthesis of [ 71041-12-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 71041-12-8 ]

[ 71041-12-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 71041-12-8 ]
  • [ 18628-07-4 ]
  • C66H41N5O [ No CAS ]
YieldReaction ConditionsOperation in experiment
68.8% With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; tri-tert-butyl phosphine; sodium t-butanolate; In toluene; at 105℃; for 24h;Inert atmosphere; In a 250 ml three-necked flask, 0.01 mol of intermediate A4, 0.024 mol of intermediate F16 was added under nitrogen protection.150 ml of toluene was stirred and mixed, and then 0.04 mol of sodium t-butoxide, 1 × 10 -4 mol of Pd 2 (dba) 3 was added.1×10-4 mol of tri-tert-butylphosphine, heated to 105 C, and refluxed for 24 hours.The sampling point plate shows that there is no bromine residue remaining, the reaction is complete; it is naturally cooled to room temperature, filtered, and the filtrate is subjected to vacuum distillation (-0.09 MPa, 85 C), and passed through a neutral silica gel column to obtain the target product.HPLC purity 99.4%, yield 68.8%;
 

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