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Chemical Structure| 712353-74-7 Chemical Structure| 712353-74-7

Structure of 712353-74-7

Chemical Structure| 712353-74-7

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Product Details of [ 712353-74-7 ]

CAS No. :712353-74-7
Formula : C16H21NO6
M.W : 323.34
SMILES Code : O=C(OC)CC(N(CCC(OC)=O)CC1=CC=C(OC)C=C1)=O

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Application In Synthesis of [ 712353-74-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 712353-74-7 ]

[ 712353-74-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 712353-74-7 ]
  • [ 712353-75-8 ]
YieldReaction ConditionsOperation in experiment
69% A mixture of an hydrous K2CO3 (3.2g, 23.2mmol, 5eq) and 18-crown-6 (azetroped several times with toluene) (122mg, 0. 464MMOL, 10MOL%) in dry toluene (4ML), under nitrogen, was heated to reflux and then treated, dropwise, over 40min, with a solution of N- (4-METHOXY- BENZYL)-N- (2-METHOXYCARBONYL-ETHYL)-MALONAMIC acid methyl ester. After 7h at reflux the reaction was diluted with water (4ML) and toluene (4ml), then cooled to 0 and carefully acudified to pH 1.7 with 0. 1N HC1. The mixture was then extracted several times with CH2C12 (3X80ML) and the combined organics dried and evaporated to a brown oil (1.33g). The brown oil was treated with 10% aqueous oxalic acid and heated to reflux for 6.5h. The mixture was then extracted repratedly with CH 2CL2 and the combined organics dried and evaporated to a dirty yellow oil (1.03g). The crude material was purified on silica gel using (CH2CL2 : MEOH 30: 1) as eluent to give 1- (4-METHOXY-BENZYL)- piperidine-2,4-dione as a pale brown solid (750mg, 69%) ; (300MHZ, CDC1 3) 2. 52 (T, J = 5.7HZ, 2H), 3.41 (s, 2H), 3.47 (t, J = 5.7Hz, 2H), 3.80 (s, 3H), 4.62 (s, 2H), 6.16-6. 88 (m, 2H), 7.20 (m, 2H).
 

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