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Chemical Structure| 71274-84-5 Chemical Structure| 71274-84-5

Structure of 71274-84-5

Chemical Structure| 71274-84-5

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Product Details of [ 71274-84-5 ]

CAS No. :71274-84-5
Formula : C13H9F3O
M.W : 238.21
SMILES Code : FC(F)(F)OC1=CC=C(C2=CC=CC=C2)C=C1
MDL No. :MFCD03412285

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Application In Synthesis of [ 71274-84-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 71274-84-5 ]

[ 71274-84-5 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 103962-05-6 ]
  • [ 71-43-2 ]
  • [ 71274-84-5 ]
YieldReaction ConditionsOperation in experiment
60% With palladium diacetate; silver nitrate; at 110℃; for 24h;Inert atmosphere; General procedure: Aryl iodides (0.5 mmol) and AgNO3 (85 mg, 0.5 mmol) and Pd(OAc)2 (11.2 mg, 0.05 mmol) were added to Schlenk tubes. Benzene (4 ml) was added to the tubes using a syringe. The mixture was then stirred in a sealed tube under argon atmosphere. Then the mixture was stirred at 110 C until complete consumption of the starting material was monitored by TLC. After completion of the reaction, the mixture was diluted with ethyl acetate, passed through a fritted glass filter to remove the inorganic salts and the solvent was removed with the aid of a rotary evaporator. The residue was purified by column chromatography on silica gel using petroleum ether/ethyl acetate as eluent to provide the desired product.
  • 2
  • [ 780-69-8 ]
  • [ 103962-05-6 ]
  • [ 71274-84-5 ]
YieldReaction ConditionsOperation in experiment
61% With bis-triphenylphosphine-palladium(II) chloride; tetrabutylphosphonium 4-ethoxyvalerate; tetrabutyl ammonium fluoride; at 130℃; for 24h;Green chemistry; General procedure: In a 4 mL screw-cap vial, 0.5 mmol of the corresponding iodoarene compounds, 1.5 eq of the corresponding silane, 1.5 eq of tetrabutylammonium fluoride (TBAF), 0.01 eq PdCl2(PPh3)2, and 0.8 mL of tetrabutylphosphonium 4-ethoxyvalerate ([TBP][4EtOV]) ionic liquid were mixed and stirred at 130 C for 24 h. After cooling, the mixture was partitioned between 5 mL of 1 M HCl and 5 mL of pentane. The aqueous phase was extracted subsequently with 3 * 5 mL of pentane. The combined organic phase was washed with brine, dried over MgSO4, and filtered, and the solvent was evaporated under reduced pressure (ca. 1.333 kPa). The residue was purified by chromatography on silica gel (Merck Silicagel 60 (0.063-0.200 mm) for column chromatography (70-230 mesh ASTM)) eluted with n-pentane:EtOAc. The detailed experimental procedure, as well as the characterization of isolated compounds are provided in the Supporting Information.
 

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