[ CAS No. 7152-24-1 ] {[proInfo.proName]}

Name: 7152-24-1|2-(Methylthio)benzimidazole|99%
Brand: Ambeed
SKU: A567052
Price: 37.0 USD
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Quality Control of [ 7152-24-1 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 7152-24-1 ]

Product Details of [ 7152-24-1 ]

CAS No. :	7152-24-1	MDL No. :	MFCD00005594
Formula :	C₈H₈N₂S	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	OCKJFOHZLXIAAT-UHFFFAOYSA-N
M.W :	164.23	Pubchem ID :	23539
Synonyms :

Calculated chemistry of [ 7152-24-1 ]

Physicochemical Properties

Num. heavy atoms :	11
Num. arom. heavy atoms :	9
Fraction Csp3 :	0.12
Num. rotatable bonds :	1
Num. H-bond acceptors :	1.0
Num. H-bond donors :	1.0
Molar Refractivity :	47.81
TPSA :	53.98 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.81 cm/s

Lipophilicity

Log Po/w (iLOGP) :	1.56
Log Po/w (XLOGP3) :	2.1
Log Po/w (WLOGP) :	2.28
Log Po/w (MLOGP) :	1.58
Log Po/w (SILICOS-IT) :	2.58
Consensus Log Po/w :	2.02

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.72
Solubility :	0.312 mg/ml ; 0.0019 mol/l
Class :	Soluble
Log S (Ali) :	-2.86
Solubility :	0.225 mg/ml ; 0.00137 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-3.4
Solubility :	0.0655 mg/ml ; 0.000399 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.47

Safety of [ 7152-24-1 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P233-P260-P261-P264-P271-P280-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 7152-24-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 7152-24-1 ]

[ 7152-24-1 ] Synthesis Path-Downstream 1~88

1
[ 186581-53-3 ]
[ 583-39-1 ]
[ 60-29-7 ]
[ 555-31-7 ]
[ 7152-24-1 ]
[ 4344-61-0 ]
[ 3418-46-0 ]

Reference： [1]Chemische Berichte,1957,vol. 90,p. 2852,2854

2
[ 186581-53-3 ]
[ 583-39-1 ]
[ 7152-24-1 ]

Reference： [1]Chemische Berichte,1957,vol. 90,p. 2852,2854

3
[ 583-39-1 ]
[ 77-78-1 ]
[ 7152-24-1 ]

Reference： [1]Patent: DE814151,1949,
DRP/DRBP Org.Chem.,

4
[ 583-39-1 ]
[ 74-88-4 ]
[ 7152-24-1 ]

Reference： [1]Tetrahedron,1995,vol. 51,p. 11515 - 11530
[2]Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan,1954,vol. 74,p. 1365,1367, 1368
Chem.Abstr.,1955,p. 15876
[3]Journal of the Chemical Society,1949,p. 3311,3314
[4]Phosphorus and Sulfur and the Related Elements,1984,vol. 20,p. 231 - 240
[5]Bioorganic and Medicinal Chemistry Letters,2008,vol. 18,p. 1573 - 1576

5
[ 7152-24-1 ]
[ 77-78-1 ]
[ 4344-61-0 ]

Reference： [1]Patent: DE814151,1949,
DRP/DRBP Org.Chem.,

6
[ 7152-24-1 ]
[ 74-88-4 ]
[ 4344-61-0 ]

Reference： [1]Journal of Organic Chemistry,1956,vol. 21,p. 24,26, 27
[2]Chemical Communications,2017,vol. 53,p. 1041 - 1044

7
[ 7152-24-1 ]
[ 74-88-4 ]
[ 3418-46-0 ]

Reference： [1]Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan,1954,vol. 74,p. 1365,1367, 1368
Chem.Abstr.,1955,p. 15876

8
[ 7152-24-1 ]
[ 57159-81-6 ]

Yield	Reaction Conditions	Operation in experiment
97%	With 1,3,5-trichloro-2,4,6-triazine; dihydrogen peroxide; In water; acetonitrile; at 20℃; for 0.333333h;	General procedure: To a mixture of sulfide (1 mmol) and TCT (1 mmol, 0.184 g) in acetonitrile (5 mL) was added 30% H2O2 (2 mmol, 0.2 mL). The mixture was stirred at room temperature for the appropriate period of time until complete consumption of the starting material as observed by TLC. After completion of the reaction, H2O (10 mL) was added to the reaction mixture which was then extracted with EtOAc (4 × 5 mL) and the combined extracts were dried (MgSO4). The filtrate was evaporated and the corresponding sulfone was obtained as the only product (Table 1).
15.5 g (89%)	With oxone; In methanol; water;	Step 1) Preparation of 2-(Methylsulfonyl)-1H-benzimidazole According to the procedure of B. M. Trost, et al., Tetrahedron Lett., 22 (14), 1287 (1981), to a cooled (0 C.), stirred solution of <strong>[7152-24-1]2-(methylthio)benzimidazole</strong> (14.5 g, 0.088 mol) in MeOH (350 mL) was added a solution of oxone (2 KHSO5.KHSO4.K2 SO4; 81.6 g, 0.133 mol) in H2 O (350 mL) over 10 minutes. The cooling bath was removed after 10 minutes, stirring was continued at room temperature for 5 hours. The MeOH was removed under reduced pressure and the white solid was collected by filtration to give 15.5 g (89%) of product m.p. 200-202 C. NMR (DMSO-d6, 300 MHz): delta3.50 (s, 3H), 7.40 (dd, J=6.2 Hz, 3-1 Hz, 2H), 7.72 (brs, 2H).

Reference： [1]Tetrahedron Letters,2011,vol. 52,p. 6420 - 6423
[2]Angewandte Chemie - International Edition,2013,vol. 52,p. 12592 - 12596
Angew. Chem.,2013,vol. 125,p. 12824 - 12828,5
[3]Green Chemistry,2017,vol. 19,p. 4061 - 4066
[4]Chemija,1959,vol. 2,p. 333,336
Chem.Abstr.,1960,p. 509
[5]Journal of Heterocyclic Chemistry,1995,vol. 32,p. 707 - 718
[6]Patent: US5149700,1992,A

9
[ 67-56-1 ]
[ 583-39-1 ]
[ 7152-24-1 ]

Reference： [1]Chemistry of Heterocyclic Compounds,1984,vol. 20,p. 656 - 658
Khimiya Geterotsiklicheskikh Soedinenii,1984,vol. 20,p. 805 - 807
[2]Journal of Organic Chemistry USSR (English Translation),1984,p. 1854
Zhurnal Organicheskoi Khimii,1984,vol. 20,p. 2031 - 2032

10
[ 7152-24-1 ]
[ 32837-87-9 ]
[ 111646-95-8 ]
[ 111244-77-0 ]

Reference： [1]Bulletin of the Academy of Sciences of the USSR Division of Chemical Science,1987,vol. 36,p. 176 - 177
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya,1987,p. 197 - 199

11
[ 7152-24-1 ]
[ 28663-68-5 ]
1-Phenyl-1H-benzo[4,5]imidazo[2,1-c][1,2,4]triazole-3-carboxylic acid ethyl ester [ No CAS ]

Reference： [1]Heterocycles,1993,vol. 36,p. 1775 - 1781

12
[ 7152-24-1 ]
[ 935-02-4 ]
[ 83256-11-5 ]

Reference： [1]Chemistry of Heterocyclic Compounds,1982,vol. 18,p. 736 - 739
Khimiya Geterotsiklicheskikh Soedinenii,1982,p. 963 - 966

13
[ 7152-24-1 ]
[ 118988-55-9 ]
(1-Phenyl-1H-benzo[4,5]imidazo[2,1-c][1,2,4]triazol-3-yl)-thiophen-2-yl-methanone [ No CAS ]

Reference： [1]Heterocycles,1993,vol. 36,p. 1775 - 1781

14
[ 7152-24-1 ]
[ 118988-56-0 ]
Thiophen-2-yl-(1-p-tolyl-1H-benzo[4,5]imidazo[2,1-c][1,2,4]triazol-3-yl)-methanone [ No CAS ]

Reference： [1]Heterocycles,1993,vol. 36,p. 1775 - 1781

15
[ 7152-24-1 ]
[ 132815-67-9 ]
1-Phenyl-1H-benzo[4,5]imidazo[2,1-c][1,2,4]triazole-3-carboxylic acid phenylamide [ No CAS ]

Reference： [1]Heterocycles,1993,vol. 36,p. 1775 - 1781

16
[ 7152-24-1 ]
[ 132815-68-0 ]
1-p-Tolyl-1H-benzo[4,5]imidazo[2,1-c][1,2,4]triazole-3-carboxylic acid phenylamide [ No CAS ]

Reference： [1]Heterocycles,1993,vol. 36,p. 1775 - 1781

17
[ 7152-24-1 ]
[ 18440-55-6 ]
1-(1-p-Tolyl-1H-benzo[4,5]imidazo[2,1-c][1,2,4]triazol-3-yl)-ethanone [ No CAS ]

Reference： [1]Heterocycles,1993,vol. 36,p. 1775 - 1781

18
[ 7152-24-1 ]
[ 132815-69-1 ]
3-ethoxycarbonyl-1-(p-methylphenyl)-1,2,4-triazolo[4,5-a]-benzimidazole [ No CAS ]

Reference： [1]Heterocycles,1993,vol. 36,p. 1775 - 1781

19
[ 7152-24-1 ]
[ 32837-89-1 ]
[ 111622-57-2 ]

Reference： [1]Bulletin of the Academy of Sciences of the USSR Division of Chemical Science,1987,vol. 36,p. 176 - 177
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya,1987,p. 197 - 199

20
[ 7152-24-1 ]
[ 4637-24-5 ]
[ 4344-61-0 ]

Reference： [1]Australian Journal of Chemistry,1981,vol. 34,p. 1729 - 1738

21
[ 7152-24-1 ]
[ 107-14-2 ]
[ 119038-45-8 ]

Reference： [1]Synthetic Communications,1988,vol. 18,p. 805 - 810
[2]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,2015,vol. 54B,p. 829 - 832

22
[ 7152-24-1 ]
[ 18440-58-9 ]
[ 81402-65-5 ]

Reference： [1]Heterocycles,1993,vol. 36,p. 1775 - 1781

23
[ 7152-24-1 ]
[ 127167-47-9 ]
[ 127166-00-1 ]

Reference： [1]Journal of Medicinal Chemistry,1992,vol. 35,p. 3402 - 3413

24
[ 7152-24-1 ]
[ 75-36-5 ]
[ 28100-30-3 ]

Reference： [1]Pharmaceutical Chemistry Journal,1992,vol. 26,p. 851 - 854
Khimiko-Farmatsevticheskii Zhurnal,1992,vol. 26,p. 50 - 53

25
[ 7152-24-1 ]
(1Z)-2-oxo-N,2-diphenylethanehydrazonoyl bromide [ No CAS ]
Phenyl-(1-phenyl-1H-benzo[4,5]imidazo[2,1-c][1,2,4]triazol-3-yl)-methanone [ No CAS ]

Reference： [1]Heterocycles,1993,vol. 36,p. 1775 - 1781

26
[ 7152-24-1 ]
C₁₈H₁₃BrN₂O [ No CAS ]
Naphthalen-2-yl-(1-phenyl-1H-benzo[4,5]imidazo[2,1-c][1,2,4]triazol-3-yl)-methanone [ No CAS ]

Reference： [1]Heterocycles,1993,vol. 36,p. 1775 - 1781

27
[ 7152-24-1 ]
C₁₉H₁₅BrN₂O [ No CAS ]
Naphthalen-2-yl-(1-p-tolyl-1H-benzo[4,5]imidazo[2,1-c][1,2,4]triazol-3-yl)-methanone [ No CAS ]

Reference： [1]Heterocycles,1993,vol. 36,p. 1775 - 1781

28
[ 7152-24-1 ]
[ 59255-03-7 ]
Phenyl-(1-p-tolyl-1H-benzo[4,5]imidazo[2,1-c][1,2,4]triazol-3-yl)-methanone [ No CAS ]

Reference： [1]Heterocycles,1993,vol. 36,p. 1775 - 1781

29
[ 7152-24-1 ]
[ 38585-67-0 ]
[ 84941-42-4 ]

Reference： [1]Archiv der Pharmazie,1983,vol. 316,p. 82 - 88

30
[ 7152-24-1 ]
[ 98639-91-9 ]

Yield	Reaction Conditions	Operation in experiment
85%	With tert.-butylhydroperoxide; bis(acetylacetonate)oxovanadium; In decane; dichloromethane; at 20℃;	t-BuOOH (solution 5.5 M in decane, 1 mL) and V0(acac)2 (5%, 0.25 mmol, 66 mg)were added in sequence to a solution of commercially available 2-(methylthio)-benzoimidazole (5 mmol, 820 mg) in CH2Cl2 (25 ml). The mixture was stirred at rt and monitored by thin-layer chromatography (TLC). At the end of there action, the solventwasremovedunderreducedpressureandthecrudewasdirectlypurifiedby flashchromatography (CHCl3/EtOAc) to obtain pure 1 as a white solid (765 mg, 4.2 mmol, 85% yield).

Reference： [1]Journal of Chemical Research,2005,p. 796 - 799
[2]Synthetic Communications,2015,vol. 45,p. 1783 - 1791
[3]Synthetic Communications,2005,vol. 35,p. 775 - 784
[4]Journal of the American Chemical Society,2004,vol. 126,p. 7800 - 7811
[5]Green Chemistry,2017,vol. 19,p. 4061 - 4066
[6]Journal of Organic Chemistry,1987,vol. 52,p. 4620 - 4622
[7]Organic Letters,2007,vol. 9,p. 2265 - 2268
[8]Bioorganic and Medicinal Chemistry Letters,2008,vol. 18,p. 1573 - 1576
[9]Russian Journal of Organic Chemistry,2011,vol. 47,p. 124 - 130

31
[ 19541-99-2 ]
[ 624-92-0 ]
[ 7152-24-1 ]

Reference： [1]Journal of Organic Chemistry,1989,vol. 54,p. 2949 - 2952

32
[ 4637-24-5 ]
[ 134469-07-1 ]
[ 7152-24-1 ]

Reference： [1]Australian Journal of Chemistry,1981,vol. 34,p. 1729 - 1738

33
[ 74-87-3 ]
[ 134469-07-1 ]
[ 7152-24-1 ]

Reference： [1]Journal of Organic Chemistry,1987,vol. 52,p. 4620 - 4622

34
[ 134469-07-1 ]
[ 77-78-1 ]
[ 7152-24-1 ]

Reference： [1]Synthetic Communications,1988,vol. 18,p. 805 - 810

35
[ 7152-24-1 ]
[ 546-68-9 ]
[ 74275-03-9 ]
1-(2'-isopropylcarbamatopropyl)-2-methylmercaptobenzimidazole [ No CAS ]

Reference： [1]Tetrahedron,1995,vol. 51,p. 11515 - 11530

36
[ 134469-07-1 ]
[ 74-88-4 ]
[ 7152-24-1 ]

Reference： [1]Ultrasonics Sonochemistry,2010,vol. 17,p. 783 - 788
[2]Bioorganic and medicinal chemistry letters,2002,vol. 12,p. 2221 - 2224
[3]Revue Roumaine de Chimie,2004,vol. 49,p. 157 - 161
[4]Journal of Molecular Structure,2021,vol. 1223
[5]Green Chemistry,2017,vol. 19,p. 4061 - 4066
[6]Journal of Heterocyclic Chemistry,1995,vol. 32,p. 707 - 718
[7]European Journal of Organic Chemistry,2010,p. 6409 - 6416
[8]Archiv der Pharmazie,2020

37
[ 95-54-5 ]
6-Chloro-7-methyl-3-methylsulfanyl-2,3-dihydro-benzo[1,4,2]dithiazine 1,1-dioxide [ No CAS ]
[ 7152-24-1 ]
[ 107466-36-4 ]
[ 197656-97-6 ]
C₂₈H₂₂Cl₂N₆O₄S₄ [ No CAS ]

Reference： [1]Acta poloniae pharmaceutica,1997,vol. 54,p. 215 - 221

38
[ 7152-24-1 ]
[ 200634-16-8 ]
Benzothiazol-2-yl-(1-oxa-2,3a,8-triaza-cyclopenta[a]inden-3-yl)-methanone [ No CAS ]

Reference： [1]Tetrahedron,1997,vol. 53,p. 17461 - 17468

39
[ 7152-24-1 ]
[ 100538-35-0 ]
3'-(2-methylsulfanyl-benzoimidazol-1-ylmethyl)-biphenyl-2-carboxylic acid [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1999,vol. 42,p. 3919 - 3933

40
[ 7152-24-1 ]
4'-formyl-[1,1'-biphenyl]-2-carboxylic acid [ No CAS ]
4'-(2-methylsulfanyl-benzoimidazol-1-ylmethyl)-biphenyl-2-carboxylic acid [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1999,vol. 42,p. 3919 - 3933

41
[ 7152-24-1 ]
4'-formyl-biphenyl-3-carboxylic acid [ No CAS ]
4'-(2-methylsulfanyl-benzoimidazol-1-ylmethyl)-biphenyl-3-carboxylic acid [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1999,vol. 42,p. 3919 - 3933

42
[ 7152-24-1 ]
(4'-formyl-biphenyl-3-yl)-acetic acid [ No CAS ]
[4'-(2-methylsulfanyl-benzoimidazol-1-ylmethyl)-biphenyl-3-yl]-acetic acid [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1999,vol. 42,p. 3919 - 3933

43
[ 7152-24-1 ]
3'-(1H-tetrazol-5-yl)-biphenyl-4-carbaldehyde [ No CAS ]
2-methylsulfanyl-1-[3'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-benzoimidazole [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1999,vol. 42,p. 3919 - 3933

44
[ 7152-24-1 ]
2'-(1H-tetrazol-5-yl)-biphenyl-3-carbaldehyde [ No CAS ]
2-methylsulfanyl-1-[2'-(1H-tetrazol-5-yl)-biphenyl-3-ylmethyl]-1H-benzoimidazole [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1999,vol. 42,p. 3919 - 3933

45
[ 7152-24-1 ]
[ 151052-40-3 ]
2-methylsulfanyl-1-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-benzoimidazole [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1999,vol. 42,p. 3919 - 3933

46
[ 7152-24-1 ]
3'-(1H-tetrazol-5-ylmethyl)-biphenyl-4-carbaldehyde [ No CAS ]
2-methylsulfanyl-1-[3'-(1H-tetrazol-5-ylmethyl)-biphenyl-4-ylmethyl]-1H-benzoimidazole [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1999,vol. 42,p. 3919 - 3933

47
[ 7152-24-1 ]
2'-(1H-tetrazol-5-ylmethyl)-biphenyl-4-carbaldehyde [ No CAS ]
2-methylsulfanyl-1-[2'-(1H-tetrazol-5-ylmethyl)-biphenyl-4-ylmethyl]-1H-benzoimidazole [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1999,vol. 42,p. 3919 - 3933

48
[ 7152-24-1 ]
2'-(1H-tetrazol-5-ylmethyl)-biphenyl-3-carbaldehyde [ No CAS ]
2-methylsulfanyl-1-[2'-(1H-tetrazol-5-ylmethyl)-biphenyl-3-ylmethyl]-1H-benzoimidazole [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1999,vol. 42,p. 3919 - 3933

49
[ 7152-24-1 ]
3'-(1H-tetrazol-5-ylmethyl)-biphenyl-3-carbaldehyde [ No CAS ]
2-methylsulfanyl-1-[3'-(1H-tetrazol-5-ylmethyl)-biphenyl-3-ylmethyl]-1H-benzoimidazole [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,1999,vol. 42,p. 3919 - 3933

Yield	Reaction Conditions	Operation in experiment
95%		Compound 42 was prepared using the same procedure as compound 4 with compound 42d and 2-(methylmercapto)benzimidazole in 95% yield: 1H NMR (CD3OD) delta 0.99 (d, J=6.5 Hz, 6H), 1.61-1.66 (m, 2H), 1.66-1.71 (m, 1H), 2.91 (s, 3H), 4.40-4.43 (m, 2H), 6.05 (s, 2H), 7.21 (td, J=2.4, 9.2 Hz, 1H), 7.27 (dd, J=2.4, 8.9 Hz, 1H), 7.43-7.51 (m, 2H), 7.63-7.65 (m, 2H), 7.76 (d, J=7.8 Hz, 1H); MS m/e 384 (MH+).

52
[ 583-39-1 ]
[ 77-78-1 ]
aqueous NaOH [ No CAS ]
[ 7152-24-1 ]
[ 4344-61-0 ]

Reference： [1]Chemische Berichte,1957,vol. 90,p. 2852,2854

53
[ 95-54-5 ]
[ 141972-53-4 ]
[ 7152-24-1 ]
[ 138416-36-1 ]

Reference： [1]Heterocycles,2001,vol. 55,p. 45 - 58

54
[ 7152-24-1 ]
C-thiazol-5-oyl-N-phenylhydrazonoyl bromide [ No CAS ]
1-phenyl-3-(4'-methyl-2'-phenylthiazol-5'-oyl)triazolo[4,3-a]benzimidazole [ No CAS ]

Reference： [1]Journal of Chemical Research, Miniprint,2000,p. 1144 - 1154

55
[ 7152-24-1 ]
C₂₂H₂₀BrClN₄O₃ [ No CAS ]
2-p-chlorophenyl-1-[3'-ethoxycarbonyl-5'-methyl-4'-(p-tolyl)]pyrazoloyl-triazolo[4,3-a]benzimidazole [ No CAS ]

Reference： [1]Phosphorus, Sulfur and Silicon and the Related Elements,2000,vol. 164,p. 181 - 188

56
[ 94906-59-9 ]
[ 7152-24-1 ]

Reference： [1]Tetrahedron Letters,2002,vol. 43,p. 399 - 402

57
[ 169905-10-6 ]
[ 134469-07-1 ]
[ 7152-24-1 ]
[ 107512-18-5 ]

Reference： [1]Synthetic Communications,2002,vol. 32,p. 1211 - 1217

58
[ 7152-24-1 ]
[ 31805-14-8 ]
1,1'-diphenyl-3,3'-bi-(1,2,4-triazolo[4,5-a]benzimidazole) [ No CAS ]

Reference： [1]Journal of the Chinese Chemical Society,2002,vol. 49,p. 1035 - 1040

59
[ 7152-24-1 ]
[ 31805-14-8 ]
1,1'-diphenyl-3,3'-bi-(1,2,4-triazolo[4,5-a]benzimidazole) [ No CAS ]

Reference： [1]Synthetic Communications,2003,vol. 33,p. 4079 - 4086

60
[ 7152-24-1 ]
C₁₄H₁₀Cl₄N₄ [ No CAS ]
1,1'-di(4-chlorophenyl)-3,3'-bi-(1,2,4-triazolo[4,5-a]benzimidazole) [ No CAS ]

Reference： [1]Synthetic Communications,2003,vol. 33,p. 4079 - 4086

61
[ 7152-24-1 ]
[ 106-95-6 ]
[ 91088-81-2 ]

Reference： [1]Revue Roumaine de Chimie,2004,vol. 49,p. 157 - 161
[2]Revue Roumaine de Chimie,2009,vol. 54,p. 643 - 650

62
[ 7152-24-1 ]
[ 845749-78-2 ]
(1-methyl-1H-benzoimidazol-2-yl)-(1-oxa-2,3a,8-triaza-cyclopenta[a]inden-3-yl)-methanone [ No CAS ]

Reference： [1]Heteroatom Chemistry,2004,vol. 15,p. 432 - 436

63
[ 7152-24-1 ]
[ 101477-74-1 ]
1-(4-methylphenyl)-3-(4-methylphenylazo)[1,2,4]triazolo[4,3-a]benzimidazole [ No CAS ]

Reference： [1]Journal of Chemical Research,2005,p. 285 - 288

64
[ 7152-24-1 ]
C₁₃H₉Cl₃N₄ [ No CAS ]
1-(3-chlorophenyl)-3-(3-chlorophenylazo)[1,2,4]triazolo[4,3-a]benzimidazole [ No CAS ]

Reference： [1]Journal of Chemical Research,2005,p. 285 - 288

65
[ 7152-24-1 ]
C₁₃H₉ClN₆O₄ [ No CAS ]
1-(4-nitrophenyl)-3-(4-nitrophenylazo)[1,2,4]triazolo[4,3-a]benzimidazole [ No CAS ]

Reference： [1]Journal of Chemical Research,2005,p. 285 - 288

66
[ 7152-24-1 ]
C₁₃H₉ClN₆O₄ [ No CAS ]
1-(3-nitrophenyl)-3-(3-nitrophenylazo)[1,2,4]triazolo[4,3-a]benzimidazole [ No CAS ]

Reference： [1]Journal of Chemical Research,2005,p. 285 - 288

67
[ 7152-24-1 ]
[ 4431-87-2 ]
1-phenyl-3-phenylazo[1,2,4]triazolo[4,3-a]benzimidazole [ No CAS ]

Reference： [1]Journal of Chemical Research,2005,p. 285 - 288

68
[ 7152-24-1 ]
[ 54337-38-1 ]
1-(4-chlorophenyl)-3-(4-chlorophenylazo)[1,2,4]triazolo[4,3-a]benzimidazole [ No CAS ]

Reference： [1]Journal of Chemical Research,2005,p. 285 - 288

69
[ 134469-07-1 ]
methyl halide [ No CAS ]
[ 7152-24-1 ]

Reference： [1]Organic Preparations and Procedures International,2005,vol. 37,p. 539 - 546

70
[ 7152-24-1 ]
[ 350-46-9 ]
C₁₄H₁₁N₃O₂S [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
25 - 45%	With potassium tert-butylate; In N,N-dimethyl-formamide; at 80℃;	To a stirred solution of a benzimidazole g (beta.OOmmols) and p- <n="137"/>fluoronitrobenzene h (6.00mmols) in 1OmL of anhydrous DMF, was added [potassium t-butoxide (f-BuOK) (7.61 mmols, 1.25eq.), and the reaction mixture was stirred at 80 0C overnight. The reaction mixture was added into 5OmL of water and the product was extracted with ethylacetate (3 x 2OmL). The extracts were washed with brine and concentrated. Column chromatography on silica gel using mixture of hexane:ethylacetate provided compound i in 25-45% yields.To a stirred solution of compound i (1.31 mmols) in 2OmL of 1 :1 CH2CI2IEtOH, was added SnCb (13.06mmols) followed by a few drops of water. The mixture was stirred overnight and concentrated. 2OmL of water was added to the residue, and the solution the brought to pH ~ 8-9 using 2N NaOH. The resulting mixture was extracted with ethylacetate (2OmL x 4), washed with brine (2OmL), dried over Na2SO-I, and concentrated to afforded compound j in 70-97% yields.To a solution of compound j (0.30mmols) in 5mL of CH2CI2, was added an acyl chloride k (0.30mmols), followed by diisopropyl-ethylamine (0.60mmols). The resultant mixture was stirred at room temperature for 30min and eluted through a short pad of silica gel using mixture of hexane:ethylacetate to afford, upon concentration, the product I in 80-96% yields.

Reference： [1]Patent: WO2007/112093,2007,A2 .Location in patent: Page/Page column 135-136; 140

71
[ 7152-24-1 ]
C₈H₈N₂SO [ No CAS ]

Reference： [1]Organic Letters,2007,vol. 9,p. 2265 - 2268

72
[ 7152-24-1 ]
(S)-2-(methylsulfinyl)benzimidazole [ No CAS ]

Reference： [1]Chemical Communications,2007,p. 2187 - 2189
[2]Advanced Synthesis and Catalysis,2009,vol. 351,p. 903 - 919

73
[ 75-15-0 ]
[ 7152-24-1 ]
3,5-dimethoxybenzyl halide [ No CAS ]
1-(3,5-dimethoxybenzyldithiocarbonyl)-2-(methylthio)benzimidazole [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2007,vol. 129,p. 12106 - 12107

74
[ 7152-24-1 ]
1-allyl-2-(p-methylphenyl)aminobenzimidazole [ No CAS ]

Reference： [1]Revue Roumaine de Chimie,2004,vol. 49,p. 157 - 161

75
[ 7152-24-1 ]
2-(methylsulfinyl)-N-methyl-benzimidazole [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2004,vol. 126,p. 7800 - 7811
[2]Synthetic Communications,2015,vol. 45,p. 1783 - 1791

76
[ 7152-24-1 ]
[ 946718-12-3 ]

Reference： [1]Journal of Heterocyclic Chemistry,1995,vol. 32,p. 707 - 718

77
[ 7152-24-1 ]
2-<4-(diphenylmethyl)piperazin-1-yl>-1-(4-fluorophenyl)methyl-1H-benzimidazole [ No CAS ]

Reference： [1]Journal of Heterocyclic Chemistry,1995,vol. 32,p. 707 - 718

78
[ 7152-24-1 ]
2-<4-(diphenylmethyl)piperazin-1-yl>-1-methyl-1H-benzimidazole [ No CAS ]

Reference： [1]Journal of Heterocyclic Chemistry,1995,vol. 32,p. 707 - 718

79
[ 7152-24-1 ]
ethyl <2-(4-(diphenylmethyl)piperazin-1-yl)-1H-benzimidazol-1-yl>acetate [ No CAS ]

Reference： [1]Journal of Heterocyclic Chemistry,1995,vol. 32,p. 707 - 718

80
[ 7152-24-1 ]
[ 114858-49-0 ]

Reference： [1]Synthetic Communications,1988,vol. 18,p. 805 - 810

81
[ 7152-24-1 ]
[ 127166-55-6 ]

Reference： [1]Journal of Medicinal Chemistry,1992,vol. 35,p. 3402 - 3413

82
[ 7152-24-1 ]
[ 75080-11-4 ]

Reference： [1]Journal of Organic Chemistry,1987,vol. 52,p. 4620 - 4622

83
[ 7152-24-1 ]
[ 2360-29-4 ]

Reference： [1]Journal of Organic Chemistry,1987,vol. 52,p. 4620 - 4622

84
[ 7152-24-1 ]
[ 51290-77-8 ]

Reference： [1]Journal of Organic Chemistry,1987,vol. 52,p. 4620 - 4622

85
[ 7152-24-1 ]
[ 5429-62-9 ]

Reference： [1]Journal of Organic Chemistry,1987,vol. 52,p. 4620 - 4622

86
[ 7152-24-1 ]
[ 110143-85-6 ]

Reference： [1]Journal of Organic Chemistry,1987,vol. 52,p. 4620 - 4622

87
[ 7152-24-1 ]
[ 104340-32-1 ]

Reference： [1]Journal of Organic Chemistry,1987,vol. 52,p. 4620 - 4622

88
[ 51-17-2 ]
[ 7152-24-1 ]

Reference： [1]Journal of Organic Chemistry,1989,vol. 54,p. 2949 - 2952

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Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
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P230	Keep wetted
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P232	Protect from moisture.
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P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
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P401
P402	Store in a dry place.
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P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
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Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]}	{[ getRatePrice(item.pr_usd, 1,1) ]}	Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]}	{[ item.pr_usastock ]}	Inquiry -	{[ item.pr_chinastock ]}	Inquiry -

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 7152-24-1 ] {[proInfo.proName]}

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Medicinal Chemistry

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[ 7152-24-1 ] Synthesis Path-Downstream 1~88

Related Functional Groups of [ 7152-24-1 ]

Sulfides

Related Parent Nucleus of [ 7152-24-1 ]

Benzimidazoles

Precautionary Statements-General

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Physical hazards

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[ 7152-24-1 ]

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[ 7152-24-1 ]