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[ CAS No. 72229-07-3 ]

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2D
Chemical Structure| 72229-07-3
Chemical Structure| 72229-07-3
Structure of 72229-07-3 *Storage: {[proInfo.prStorage]}

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Product Details of [ 72229-07-3 ]

CAS No. :72229-07-3MDL No. :MFCD22495173
Formula : C8H12O4 Boiling Point : 204°C at 760 mmHg
Linear Structure Formula :-InChI Key :N/A
M.W :172.18Pubchem ID :274392
Synonyms :

Computed Properties of [ 72229-07-3 ]

TPSA : 52.6 H-Bond Acceptor Count : 4
XLogP3 : 0.5 H-Bond Donor Count : 0
SP3 : 0.75 Rotatable Bond Count : 5

Safety of [ 72229-07-3 ]

Signal Word:WarningClass:N/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 72229-07-3 ]

  • Upstream synthesis route of [ 72229-07-3 ]
  • Downstream synthetic route of [ 72229-07-3 ]

[ 72229-07-3 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 623-73-4 ]
  • [ 108-05-4 ]
  • [ 72229-07-3 ]
YieldReaction ConditionsOperation in experiment
86 % de With Cu exchanged bentonite In neat (no solvent) at 80℃; for 0.333333 h; Microwave irradiation General procedure: Method A (MWI): in this study a continuous focusedmicrowave (synthewave 402 apparatus with a max power of300 W) with refluxing and stirring option was used. Thereaction temperature was reached a target temperature after3min then maintained by device until the end of reaction.The temperature was detected by IR sensor.The mixture of the alkene (6 mmol) and the exchangedbentonite 50 mg was irradiated at 150 Watts to reach 80°C,in a quartz reactor ( = 1.8 cm). The temperature was maintainedfor 20 minutes and during that time, EDA (6 mmol) inalkene (6mmol) was added slowly by a syringe during 10min. When the reaction was complete, the crud mixture wasobtained after adding dichloromethane (3x20mL), filtrationand removal of the excess of alkene and solvent. The crudewas analyzed by 1H NMR and then the product is purified byshort-path distillation. The obtained cyclopropane is identifiedby 1H NMR, 13C NMR and mass spectra.
Reference: [1] Helvetica Chimica Acta, 1995, vol. 78, # 2, p. 459 - 470
[2] Journal of the American Chemical Society, 2002, vol. 124, # 6, p. 978 - 983
[3] Letters in Organic Chemistry, 2016, vol. 13, # 3, p. 217 - 223
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