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Chemical Structure| 72351-42-9 Chemical Structure| 72351-42-9

Structure of 72351-42-9

Chemical Structure| 72351-42-9

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Product Details of [ 72351-42-9 ]

CAS No. :72351-42-9
Formula : C12H15NO2
M.W : 205.25
SMILES Code : OCC1N(C(C2=CC=CC=C2)=O)CCC1
MDL No. :MFCD03790911

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Application In Synthesis of [ 72351-42-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 72351-42-9 ]

[ 72351-42-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 98-88-4 ]
  • [ 498-63-5 ]
  • [ 72351-42-9 ]
YieldReaction ConditionsOperation in experiment
77.5% With sodium carbonate; In chloroform; water; acetone; benzene; (1) To a solution of 3.40 g (3.21 mmoles) of <strong>[498-63-5]2-hydroxymethylpyrrolidine</strong> [prepared in the manner described in J. O. C. 32, 2388 (1967) by P. G. Gassman and A. Fentiman] in a mixture of 20 ml of acetone and 4 ml of water are dropwise added 5.0 ml (1.34 equivalents) of benzoyl chloride and 10 ml of an aqueous solution of 4.5 g (1.34 equivalents) of sodium carbonate at the same time and after 30 minutes, water is added thereto. The mixture is extracted with methylene chloride. The organic layer is separated, washed with water, dried over sodium sulfate and evaporated under reduced pressure to yield 8.4 g of the residue, which is adsorbed on a column of 84 g of Kiesel Gel 60 (prepared by Merck Co.) and eluted with benzene, a mixture of benzene and chloroform, and chloroform, successively. The elude is evaporated under reduced pressure to yield 5.1 g of oily 1-benzoyl-<strong>[498-63-5]2-hydroxymethylpyrrolidine</strong> in 77.5percent yield. IR: numaxfilm 3400, 1615, 1607, 1575, 1500 cm-1.
  • 2
  • [ 65-85-0 ]
  • [ 498-63-5 ]
  • [ 72351-42-9 ]
 

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