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Chemical Structure| 72756-21-9 Chemical Structure| 72756-21-9

Structure of 72756-21-9

Chemical Structure| 72756-21-9

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Product Details of [ 72756-21-9 ]

CAS No. :72756-21-9
Formula : C13H17NO3
M.W : 235.28
SMILES Code : CC(C)(C)C(NC(C1=CC=CC=C1)=O)C(O)=O
MDL No. :N/A

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Application In Synthesis of [ 72756-21-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 72756-21-9 ]

[ 72756-21-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 33105-81-6 ]
  • [ 98-88-4 ]
  • [ 72756-21-9 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; sodium hydroxide; In water; ethyl acetate; EXAMPLE 2 N-benzoyl-DL-<strong>[33105-81-6]tert-leucine</strong> A suspension of DL-<strong>[33105-81-6]tert-leucine</strong> (327.5 g, 2.5 mol) in water (833 ml) was cooled to 5° C. A solution of sodium hydroxide (220 g, 5.5 mol) in water (833 ml) was added dropwise over 90 min maintaining the temperature at about 5° C. After a further 30 min stirring benzoyl chloride (386 g, 2.75 mol) was added dropwise over 2.5 h keeping the temperature at about 5° C. The temperature was then allowed to warm slowly to 10° C. over 3 hours until the reaction was complete. Ethyl acetate (2.25 l) was added and the pH adjusted to 1.5 using 6M hydrochloric acid (460 ml) keeping the temperature between 5-10° C. A white solid was precipitated which was dissolved by heating the mixture to 40° C. The two layers were separated and the organic layer concentrated to about 1 l. On cooling a white solid crystallized which was collected by filtration, washing with cold ethyl acetate, and dried (466 g, 79percent). A second crop of crystals was recovered (56.0 g, 10 percent).
 

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