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Chemical Structure| 727736-62-1 Chemical Structure| 727736-62-1

Structure of 727736-62-1

Chemical Structure| 727736-62-1

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Product Details of [ 727736-62-1 ]

CAS No. :727736-62-1
Formula : C7H7NO4
M.W : 169.13
SMILES Code : O=C(C1=CC=C(O)C=[N+]1[O-])OC

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Application In Synthesis of [ 727736-62-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 727736-62-1 ]

[ 727736-62-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 727736-62-1 ]
  • [ 143-33-9 ]
  • [ 727736-63-2 ]
YieldReaction ConditionsOperation in experiment
With chloro-trimethyl-silane; triethylamine; In DMF (N,N-dimethyl-formamide); at 80.0℃; for 28.3333h; Reference Example 36: Methyl 6-cyano-5-hydroxypyridine-2-carboxylate [] Methyl 5-hydroxypyridine-2-carboxylate 1-oxide (5.18 g) obtained in Reference Example 35, sodium cyanide (4.50 g) and triethylamine (29.9 ml) are added to N,N-dimethylformamide (55 ml), and thereto is added chlorotrimethylsilane (19.4 ml) over 20 minutes. The mixture is then stirred at 80C for 28 hours. The reaction solution is cooled to room temperature, filtered to remove the insoluble materials and the filtrate is concentrated under reduced pressure. Methanol (150 ml) is added to the residue, and the mixture is stirred at room temperature for 30 minutes and evaporated to remove the solvent under reduced pressure. The residue is purified by silica gel column chromatography (eluent: chloroform to methanol/chloroform = 1/5). The resulting solid is suspended in diethyl ether and collected by filtration to give the title compound (4.66 g). ESI-MS M/Z:177[M-H]-.
 

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