[ CAS No. 734524-15-3 ] {[proInfo.proName]}

Name: 734524-15-3|7-Fluoroquinoline-3-carboxylic acid|95%
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SKU: A756438
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Quality Control of [ 734524-15-3 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 734524-15-3 ]

Product Details of [ 734524-15-3 ]

CAS No. :	734524-15-3	MDL No. :	MFCD09787869
Formula :	C₁₀H₆FNO₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	PXJCGANFXZBADU-UHFFFAOYSA-N
M.W :	191.16	Pubchem ID :	17040038
Synonyms :

Safety of [ 734524-15-3 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 734524-15-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 734524-15-3 ]

[ 734524-15-3 ] Synthesis Path-Downstream 1~3

Yield	Reaction Conditions	Operation in experiment
16%

2
[ 734524-15-3 ]
3-(2-amino-5-chloro-4-methoxyphenyl)-4,5-dihydro-1,2,4-oxadiazol-5-one [ No CAS ]
N-(4-chloro-5-methoxy-2-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl)-7-fluoroquinoline-3-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With N-ethyl-N,N-diisopropylamine; HATU In 1,2-dichloro-ethane at 60℃; for 12h;	94.4 Step 4. Into a 25-mL round-bottom flask was placed 7-fluoroquinoline-3-carboxylic acid (100 mg, 0.52 mmol), DCE (4 mL), 3-(2-amino-5-chloro-4-methoxyphenyl)-4,5-dihydro-1,2,4-oxadiazol-5-one (138.8 mg, 0.57 mmol), HATU (258.6 mg, 0.68 mmol) and DIEA (202.6 mg, 1.57 mmol). The resulting solution was stirred for 12 hrs at 60 °C in an oil bath. The resulting mixture was concentrated under vacuum and washed with 10 mL of methanol. The solids were collected by filtration to afford the title compound as a light yellow solid. LC-MS 415 (M+H)+.

Reference： [1]Current Patent Assignee: INCEPTION 1 - WO2017/192304, 2017, A1 Location in patent: Paragraph 0321

3
[ 666859-55-8 ]
[ 734524-15-3 ]
N-(4-bromo-2-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl)-7-fluoroquinoline-3-carboxamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With N-ethyl-N,N-diisopropylamine; HATU In 1,2-dichloro-ethane at 60℃; for 12h;	121.3 Step 3: N-(4-bromo-2-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl)-7-fluoroquinoline-3-carboxamide. Into a 25-mL round-bottom flask was placed 7-fluoroquinoline- 3-carboxylic acid (200 mg, 1.05 mmol), DCE (10 mL), 3-(2-amino-5-bromophenyl)-4,5-dihydro-1,2,4-oxadiazol-5-one (293.7 mg, 1.15 mmol), HATU (596.9 mg, 1.57 mmol), DIEA (405.2 mg, 3.14 mmol). The resulting solution was stirred for 12 hrs at 60 °C in an oil bath. The resulting solution was diluted with 10 mL of methanol. The solids were collected by filtration. This resulted in 290 mg (crude) of N-[4-bromo-2-(5-oxo-4,5-dihydro-l,2,4-oxadiazol-3-yl)phenyl]-7-fluoroquinoline-3-carboxamide as a yellow solid.

Reference： [1]Current Patent Assignee: INCEPTION 1 - WO2017/192304, 2017, A1 Location in patent: Paragraph 0374

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Code	Phrase
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P230	Keep wetted
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P232	Protect from moisture.
P233	Keep container tightly closed.
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P320
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P321
P322
P330	Rinse mouth.
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P337	If eye irritation persists:
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P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
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P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
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P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
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P378
P380	Evacuate area.
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P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
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P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
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P401
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P411
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P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
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H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
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H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
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H281	Contains refrigerated gas; may cause cryogenic burns or injury
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Health hazards
Code	Phrase
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H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
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H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
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H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
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H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 734524-15-3 ] {[proInfo.proName]}

Quality Control of [ 734524-15-3 ]

Related Doc. of [ 734524-15-3 ]

Product Details of [ 734524-15-3 ]

Safety of [ 734524-15-3 ]

Application In Synthesis of [ 734524-15-3 ]

[ 734524-15-3 ] Synthesis Path-Downstream 1~3

Related Functional Groups of [ 734524-15-3 ]

Fluorinated Building Blocks

Carboxylic Acids

Related Parent Nucleus of [ 734524-15-3 ]

Quinolines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

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Related Functional Groups of
[ 734524-15-3 ]

Related Parent Nucleus of
[ 734524-15-3 ]