Home Cart Sign in  
Chemical Structure| 73604-31-6 Chemical Structure| 73604-31-6
Chemical Structure| 73604-31-6

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

3-(Aminomethyl)phenol (m-Hydroxybenzylamine) can reduce dopamine levels in the prefrontal cortex.

Synonyms: m-Hydroxybenzylamine

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Product Citations

O' ; Shea, KE ; Restrepo-Osorio, Rodrigo ;

Abstract: Poly- and perfluoroalkyl substances (PFAS) are pollutants of serious concern due to their adverse health effects, widespread use, and resistance to degradation. β-cyclodextrins (β-CDs) form strong β-CD:PFAS complexes with a wide variety of PFAS. We report herein the incorporation of ionizable functional groups on the primary rim of β-CD, to control the complexation of PFAS as a function of solution pH. The binding constants (KCD:PFAS) of short-chain and long-chain PFAS by amino-β-CDs and thiol-β-CDs decrease by 56 to 98 % with a change in solution pH from neutral to alkaline conditions. The observed reduction in binding constants (KCD:PFAS) with increased pH is assigned to the increased electrostatic repulsion between negatively charged functional group amended to the β-CD (host) and negatively charged PFAS polar head group (guest) under alkaline conditions. The inclusion of two pH-dependent ionizable functional groups to the host was achieved by employing 6-(3-hydroxybenzylamino)-6-deoxy-β- cyclodextrin [(3-OH)BnNHβ-CD]. The phenol functionality is converted from a neutral to an anionic species while the benzyl-amino group is cationic under neutral pH and converted to neutral charge under alkaline conditions, thus the β-CD host can be converted from a positive charge to a negative charge by varying solution pH. The (3-OH)BnNHβ-CD exhibits strong pH-modulated binding with long-chain perfluorocarboxylic acids (PFCAs), evidenced in an 88 % decrease in the association constant with PFOA under alkaline conditions. The association constant for (3-OH)BnNHβ-CD with hexafluoropropylene oxide dimer acid (HFPO-DA), a branched perfluoroether carboxylic acid (PFECA), however, decreases by nearly 50 % under alkaline conditions compared to an 81 % and 98 % decrease observed for mono-thiol and mono-amino β-CDs, respectively. A 95 % decrease in binding in PFOA is observed for mono-thiol-β-CD, while heptakis-(6-mercapto-6-deoxy)-β-cyclodextrin, with seven ionizable thiol groups leads to a modest 23 % decrease for complexation of PFOA with change from neutral to alkaline pH. Steric effects due to chain branching within PFAS in combination with size and number of substituents on the β-CD reduce the impact of pH effects on binding. This study demonstrates derivatization of β-CD with pH ionizable functional groups can be used to control the β-CD binding of PFAS as a possible strategy for the removal and recovery of PFAS from contaminated water streams.

Keywords: Host-guest complexation ; PFAS ; cyclodextrin ; remediation: pH

Purchased from AmBeed: ; ; ;

Alternative Products

Product Details of 3-(Aminomethyl)phenol

CAS No. :73604-31-6
Formula : C7H9NO
M.W : 123.15
SMILES Code : OC1=CC=CC(CN)=C1
Synonyms :
m-Hydroxybenzylamine
MDL No. :MFCD00798977
InChI Key :JNZYADHPGVZMQK-UHFFFAOYSA-N
Pubchem ID :735894

Safety of 3-(Aminomethyl)phenol

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of 3-(Aminomethyl)phenol

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 73604-31-6 ]

[ 73604-31-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 73604-31-6 ]
  • [ 4385-76-6 ]
  • N-(3-hydroxybenzyl)-4-(pyridin-4-yl)benzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
62 mg With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20℃; for 2h; To a solution of <strong>[4385-76-6]4-(pyridin-4-yl)benzoic acid</strong> (50 mg, 0.25 mmol) and 3- (aminomethyl)phenol (37 mg, 0.3 mmol) in DMF were added diisopropylethylamine (DIEA, 0.13 mL, 0.75 mmol) and FJATU (123 mg, 0.32 mmol). The reaction was stirred at room temperature for 2 hrs and diluted with water. The mixture was concentrated and purified by C-18 column chromatography to give 3 A (62 mg).
 

Historical Records

Technical Information

Categories