Alternatived Products of [ 74058-21-2 ]
Product Details of [ 74058-21-2 ]
CAS No. : | 74058-21-2 |
MDL No. : | MFCD11036247 |
Formula : |
C8H16O2
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
144.21
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Pubchem ID : | - |
Synonyms : |
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Application In Synthesis of [ 74058-21-2 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 74058-21-2 ]
Yield | Reaction Conditions | Operation in experiment |
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aus Ester; |
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4-Hydroxy-cyclohexyl-essigsaeure-methylester, LiAlH4; |
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- 2
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[ 501-94-0 ]
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[ 74058-21-2 ]
Yield | Reaction Conditions | Operation in experiment |
99% |
With borax; hydrogen In isopropyl alcohol at 80℃; for 22h; |
U.1
In a 1 L reactor are successively introduced : 50 g (362 mmol) of 4-(2- hydroxyethyl)phenol, 5 g (13,6 mmol) of sodium tetraborate decahydrate, 500 ml_ of isopropanol, 5 g of palladium (10% on charcoal washed with isopropanol). The vessel is closed, purged three times with nitrogen and three times with hydrogen. The mixture is stirred for 22 hours under 10 bar pressure of hydrogen at 800C, cooled back to room temperature, filtered over a celite pad and rinsed with isopropanol. Filtrate is concentrated under reduced pressure, toluene (100 ml_) is added and evaporated under reduced pressure. This last procedure being repetited to remove trace amount of isopropanol and gives 52 g (99% yield) of 4-(2-hydroxyethyl)cyclohexanol as a clear viscous oil.TLC (ethyl acetate/heptane 75/25): Rf = 0.2 |
- 3
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[ 74058-21-2 ]
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[ 32863-01-7 ]
Yield | Reaction Conditions | Operation in experiment |
95% |
Stage #1: 4-(2-Hydroxyethyl)cyclohexanol With acetic acid at 18 - 21℃; for 0.583333h;
Stage #2: With sodium hypochlorite In water for 0.75h; |
U.2
To a solution of 10 g (69 mmol) of 4-(2-hydroxyethyl)cyclohexanol in 50 mL of acetic acid maintained at a temperature between 18 and 210C are added over 35 min 35.9ml_ (79mmol) of an aqueous sodium hypochlorite solution. The mixture is further stirred for 45 min, TLC analysis indicating disappearance of starting material. Isopropanol (0.8 mL) is added, followed 10 min later by water (75 mL) and dichloromethane (100 mL). The two phases are separated by decantation and the aqueous phase is extracted with dichloromethane (50 ml_). Combined organic phases are washed with an aqueous 3N sodium hydroxide solution (70 ml_). This alcaline aqueous phase is extraced back with dichloromethane (30 ml_). Combined organic phases are dried over magnesium sulfate and concentrated under reduced pressure to give 9.42 g (95%) of the title compound.TLC (ethyl acetate/heptane 75/25): Rf = 0.29 |
- 4
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[ 74058-21-2 ]
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2-(4-(benzyloxy)cyclohexyl)ethan-1-ol
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 3 steps
1: triethylamine; dmap / dichloromethane / 1 h / 0 °C
2: sodium hydride; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide; mineral oil / 3 h
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h |
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Reference:
[1]Hayashi, Yujiro; Mukaiyama, Takasuke; Benohoud, Meryem; Gupta, Nishant R.; Ono, Tsuyoshi; Toda, Shunsuke
[Chemistry - A European Journal, 2016, vol. 22, # 17, p. 5868 - 5872]
- 5
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[ 74058-21-2 ]
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[ 18162-48-6 ]
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4-(2-((tert-butyldimethylsilyl)oxy)ethyl)cyclohexan-1-ol
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
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With dmap; triethylamine In dichloromethane at 0℃; for 1h; |
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Reference:
[1]Hayashi, Yujiro; Mukaiyama, Takasuke; Benohoud, Meryem; Gupta, Nishant R.; Ono, Tsuyoshi; Toda, Shunsuke
[Chemistry - A European Journal, 2016, vol. 22, # 17, p. 5868 - 5872]
- 6
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[ 74058-21-2 ]
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[ 18162-48-6 ]
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(2-(4-(benzyloxy)cyclohexyl)ethoxy)(tert-butyl)dimethylsilane
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 2 steps
1: triethylamine; dmap / dichloromethane / 1 h / 0 °C
2: sodium hydride; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide; mineral oil / 3 h |
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Reference:
[1]Hayashi, Yujiro; Mukaiyama, Takasuke; Benohoud, Meryem; Gupta, Nishant R.; Ono, Tsuyoshi; Toda, Shunsuke
[Chemistry - A European Journal, 2016, vol. 22, # 17, p. 5868 - 5872]
- 7
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[ 74058-21-2 ]
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[ 1000044-40-5 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 3 steps
1.1: acetic acid / 0.58 h / 18 - 21 °C
1.2: 0.75 h
2.1: triethylamine / dichloromethane / 2 h / 20 °C
3.1: potassium carbonate / acetonitrile / Heating / reflux |
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- 8
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[ 74058-21-2 ]
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[ 198640-16-3 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 2 steps
1.1: acetic acid / 0.58 h / 18 - 21 °C
1.2: 0.75 h
2.1: triethylamine / dichloromethane / 2 h / 20 °C |
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