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Chemical Structure| 741288-41-5 Chemical Structure| 741288-41-5

Structure of 741288-41-5

Chemical Structure| 741288-41-5

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Product Details of [ 741288-41-5 ]

CAS No. :741288-41-5
Formula : C12H15F2N
M.W : 211.25
SMILES Code : FC1(F)CN(CC2=CC=CC=C2)CCC1
MDL No. :MFCD06657949

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Application In Synthesis of [ 741288-41-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 741288-41-5 ]

[ 741288-41-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 741288-41-5 ]
  • [ 496807-97-7 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; hydrogen;5% palladium-on-charcoal; In methanol; ethanol; for 22h; To a solution of 1-benzyl-piperidin-3-one (1G) in CH2CI2 (LOML) is added [bis (2-methoxy- ethyl) amino] SULFER TRIFLUORIDE (1. 84mL) at 0C, and stirred for 1.5hr at room temperature. The reaction mixture is poured in aqueous NaHC03 and extracted with ethyl acetate. The organic layer is successively washed with H20 and aqueous NACI, dried over MgS04, and concentrated in vacuo. The residue is purified by column chromatography to give a colorless oil. The oil and Pd/C (5% w/w on activated carbon, 100MG) in HCI in ETOH/MEOH (50mL) is stirred for 22hr under H2 atmosphere. The reaction mixture is filtrated through celite pad. 4The filtrate is added HCI in EtOAc, then concentrated in vacuo to provide the title compound.
 

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