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Chemical Structure| 74258-81-4 Chemical Structure| 74258-81-4

Structure of 74258-81-4

Chemical Structure| 74258-81-4

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Product Details of [ 74258-81-4 ]

CAS No. :74258-81-4
Formula : C11H14N4O3
M.W : 250.25
SMILES Code : NC1=NC(C2=CC(OC)=C(OC)C(OC)=C2)=NN1
MDL No. :MFCD00461055

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Application In Synthesis of [ 74258-81-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 74258-81-4 ]

[ 74258-81-4 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 504-02-9 ]
  • [ 74258-81-4 ]
  • [ 31680-08-7 ]
  • 9-(4-methoxy-3-nitrophenyl)-2-(3,4,5-trimethoxyphenyl)-5,6,7,9-tetrahydro-1H-[1,2,4]triazolo[5,1-b]quinazolin-8-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
86% With toluene-4-sulfonic acid; In N,N-dimethyl-formamide; at 90℃; for 12h; General procedure: To a mixture of aldehyde (0.3mmol), cyclohexane-1,3-dione or pentane-2,4-dione (0.3mmol), 3-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazol-5-amine (0.3mmol), p-toluenesulfonic acid (0.015mmol), and DMF (5mL) was added. The resulting solution was stirred at 90C for 12h, and was then treated with saturated sodium bicarbonate solution (15mL) and extracted with EtOAc (3×15mL). The combined organic layers was then dried over anhydrous MgSO4 and evaporated in vacuo. The crude residue was purified by silica gel column chromatography using a mixture of petroleum ether and acetone as an eluent to give the pure solid compounds 7-30 in yields of 53-95%.
  • 2
  • [ 74258-81-4 ]
  • [ 123-54-6 ]
  • [ 31680-08-7 ]
  • 1-[7-(4-methoxy-3-nitrophenyl)-5-methyl-2-(3,4,5-trimethoxyphenyl)-1,7-dihydro-[1,2,4] triazolo[1,5-a]pyrimidin-6-yl]ethanone [ No CAS ]
YieldReaction ConditionsOperation in experiment
89% With toluene-4-sulfonic acid; In N,N-dimethyl-formamide; at 90℃; for 12h; General procedure: To a mixture of aldehyde (0.3mmol), cyclohexane-1,3-dione or pentane-2,4-dione (0.3mmol), 3-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazol-5-amine (0.3mmol), p-toluenesulfonic acid (0.015mmol), and DMF (5mL) was added. The resulting solution was stirred at 90C for 12h, and was then treated with saturated sodium bicarbonate solution (15mL) and extracted with EtOAc (3×15mL). The combined organic layers was then dried over anhydrous MgSO4 and evaporated in vacuo. The crude residue was purified by silica gel column chromatography using a mixture of petroleum ether and acetone as an eluent to give the pure solid compounds 7-30 in yields of 53-95%.
  • 3
  • [ 17641-08-6 ]
  • [ 74258-81-4 ]
  • 2-[5-amino-3-(3,4,5-trimethoxyphenyl)[1,2,4]triazol-1-yl]-N-(3-methoxyphenyl)acetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
69% With potassium carbonate; In N,N-dimethyl-formamide; at 80℃; for 6h; General procedure: To a solution of 3-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazol-5-amine 11 (1.0 mmol) and the intermediate chloro acetamide (1.02 mmol) in 8 mL anhydrousN,N-Dimethylformamide was added K2CO3 (152 mg, 1.1 mmol). The reactions were stirred at 80 C for 6 h. After reaction completed, thesolution was cooled and poured slowly in 20 mL water, and was extracted with ethyl acetate (3×20 mL). The organic phase was then washedwith water, and dried over anhydrous Na2SO4. The combined organic layer was concentrated under reduced pressure and was further purified bycolumn chromatography using petroleum ether/acetone as eluent to provide target compounds IIIa-n.
 

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