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Chemical Structure| 74346-20-6 Chemical Structure| 74346-20-6

Structure of 74346-20-6

Chemical Structure| 74346-20-6

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Product Details of [ 74346-20-6 ]

CAS No. :74346-20-6
Formula : C9H8BrClO
M.W : 247.52
SMILES Code : O=C(Cl)C1=C(C)C=C(Br)C=C1C
MDL No. :MFCD27928216

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Application In Synthesis of [ 74346-20-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 74346-20-6 ]

[ 74346-20-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 74346-20-6 ]
  • [ 42303-42-4 ]
  • [ 1233333-58-8 ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20℃; Example EX81; 1-({3'-[(R)-1-(4-Chloro-3-methyl-phenyl)-ethylamino]-3,5-dimethyl-biphenyl-4-carbonyl}-methyl-amino)-cyclopropanecarboxylic acid; (1) 1-(4-Bromo-2,6-dimethyl-benzoylamino)-cyclopropanecarboxylic acid ethyl ester, INT36; To a suspension of 4-bromo-2,6-dimethyl-benzoic acid (864 mg, 3.77 mmol) in DCM (19 mL) a few drops of DMF and thionyl chloride (0.561 mL, 7.44 mmol) were added and the resulting mixture was refluxed for 1 hour. The mixture was then concentrated under reduced pressure and taken up in THF (19 mL). DIPEA (3.49 mL, 18.87 mmol) was then added, followed by ethyl 1-amino-1-cyclopropanecarboxylate hydrochloride (1.25 g, 7.44 mmol) and the mixture was stirred at room temperature overnight. The mixture was diluted in EtOAc, washed with 1M HCl, saturated aqueous sodium bicarbonate and brine, dried over sodium sulfate, filtered and concentrated. The residue was purified by chromatography on silica gel (cyclohexane/EtOAc) to give INT36 as a white foam.LC/MS method 2: MS (ESI): 340 [M+H]+, rt=2.19 min. 1H-NMR (DMSO-d6): delta (ppm) 8.94 (s, 1H), 7.27 (s, 211, 4.08 (q, 2H), 2.22 (s, 6H), 1.42 (q, 2H), 1.18 (t, 3H), 1.09 (q,
 

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