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Chemical Structure| 74483-47-9 Chemical Structure| 74483-47-9

Structure of 74483-47-9

Chemical Structure| 74483-47-9

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Product Details of [ 74483-47-9 ]

CAS No. :74483-47-9
Formula : C8H6ClF3
M.W : 194.58
SMILES Code : FC(C1=CC=C(C)C(Cl)=C1)(F)F
MDL No. :MFCD11226657

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Application In Synthesis of [ 74483-47-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 74483-47-9 ]

[ 74483-47-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 383-62-0 ]
  • [ 83846-48-4 ]
  • [ 74483-47-9 ]
YieldReaction ConditionsOperation in experiment
With potassium fluoride;copper(I) iodide; In diethyl ether; water; N,N-dimethyl-formamide; Preparation Example 4-1 2-Chloro-4-iodotoluene(22.0 g) was dissolved in N,N-dimethylformamide (110 ml), and copper(I) iodide (49.8 g), <strong>[383-62-0]ethyl chlorodifluoroacetate</strong> (37.8 g) and potassium fluoride (15.2 g) were added. The mixture was stirred at internal temperature of 116C for 70 hr. The reaction mixture was filtered through celite. Water (11 ml) and diethyl ether (110 ml) were added to the filtrate under ice-cooling and the mixture was filtered through -celite. The filtrate was separated and the aqueous layer was extracted again with diethyl ether (110 ml). The organic layers were combined and washed with saturated brine (110 ml), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give 2-chloro-4-trifluoromethyltoluene (23.0 g) as a brown oil. 1H-NMR(CDCl3): 2.43(3H, s), 7.34(1H, d, J=8Hz), 7.42(1H, d, J=8Hz), 7.60(1H, s).
 

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