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Chemical Structure| 746671-35-2 Chemical Structure| 746671-35-2

Structure of 746671-35-2

Chemical Structure| 746671-35-2

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Product Details of [ 746671-35-2 ]

CAS No. :746671-35-2
Formula : C11H17NO2
M.W : 195.26
SMILES Code : O=C(C1=CC(C(C)(C)C)=CN1)OCC

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Application In Synthesis of [ 746671-35-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 746671-35-2 ]

[ 746671-35-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 746671-35-2 ]
  • [ 4761-00-6 ]
  • ethyl 4-tert-butyl-1-[(2,4,6-trimethylphenyl)methyl]-1H-pyrrole-2-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
98% Sodium hydride (24 mg as a 60% dispersion in mineral oil, 0.60 mmol) was added to a solution of ethyl 4-tert-butyl-1H-pyrrole-2-carboxylate (0.10 g, 0.51 mmol) in N,N-dimethylformamide (3 mL) at 0 C. The mixture was allowed to stir at 0 C. for 5 min before it was stirred at room temperature for 30 min. 2,4,6-Trimethylbenzyl bromide (0.12 g, 0.55 mmol) was added portion-wise and the mixture was stirred at room temperature for 20 h. The reaction mixture was quenched at 0 C. with aqueous saturated NH4Cl (4 mL). The mixture was extracted with ethyl acetate (80 mL) and the organic layer was washed with brine (2×30 mL) and water (30 mL), dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by silica gel chromatography (0-15% ethyl acetate/heptanes) to afford 4-ten-butyl-1-[(2,4,6-trimethylphenyl)methyl]-1H-pyrrole-2-carboxylate (161 mg, 98%) as a white solid. NMR (300 MHz, CDCl3) delta 1.12 (s, 9H), 1.38 (t, J=7.1 Hz, 3H), 2.20 (s, 6H), 2.31 (s, 3H), 4.31 (q, J=7.1 Hz, 2H), 5.47 (s, 2H), 6.11 (d, J=2.1 Hz, 1H), 6.91 (s, 2H), 6.92 (d, J=2.1, 1H).
  • 2
  • [ 746671-35-2 ]
  • [ 4761-00-6 ]
  • 4-tert-butyl-1-[(2,4,6-trimethylphenyl)methyl]-1H-pyrrole-2-carboxylic acid [ No CAS ]
 

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