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Chemical Structure| 7506-48-1 Chemical Structure| 7506-48-1

Structure of 7506-48-1

Chemical Structure| 7506-48-1

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Product Details of [ 7506-48-1 ]

CAS No. :7506-48-1
Formula : C14H11NO2
M.W : 225.24
SMILES Code : C1(COC2=CC=CC=C2)=NC3=CC=CC=C3O1
MDL No. :MFCD02017993

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Application In Synthesis of [ 7506-48-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 7506-48-1 ]

[ 7506-48-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 41014-43-1 ]
  • [ 108-95-2 ]
  • [ 7506-48-1 ]
YieldReaction ConditionsOperation in experiment
75.56% With potassium carbonate; In acetone; for 4h;Reflux; General procedure: To a solution of various substituted phenols (1 mmol) in dry acetone (30 mL) K2CO3 (1 mmol)and compound 3 or 4 (1 mmol) were added. After being stirred for 4 h at reflux temperature, thereaction mixture was cooled, filtered, and concentrated under vacuum. Then the residue was dilutedwith 30 mL ethyl acetate and sequentially washed with 30 mL 1 M HCl, aq. NaHCO3 solution andbrine in order. The organic layer was dried over MgSO4 and concentrated in vacuo. Purification of theresidue by chromatography on silica gel furnished target compounds. 1H-NMR, 13C-NMR and massspectroscopy (MS) of compounds 5a-m and 6a-m are shown in Supplementary Materials. 2-(phenoxymethyl)benzo[d]oxazole (5a): Yellow solid; yield, 75.56%; m.p., 154-156 C; 1H-NMR (500 MHz,CDCl3) delta 7.76 (m, 1H, ArH), 7.56 (d, J = 6.9 Hz, 1H, ArH), 7.37 (m, 2H, ArH 2), 7.32 (t, J = 7.7 Hz, 2H,ArH 2), 7.07 (d, J = 8.4 Hz, 2H, ArH 2), 7.02 (t, J = 7.3 Hz, 1H, ArH), 5.33 (s, 2H, CH2); and ESI-MSm/z: 225.94 ([M + H]+), 247.92 ([M + Na]+).
 

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