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Chemical Structure| 752242-26-5 Chemical Structure| 752242-26-5

Structure of 752242-26-5

Chemical Structure| 752242-26-5

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Product Details of [ 752242-26-5 ]

CAS No. :752242-26-5
Formula : C10H12O4
M.W : 196.20
SMILES Code : O=C(O)C1=CC(OC(C)C)=CC(O)=C1

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Application In Synthesis of [ 752242-26-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 752242-26-5 ]

[ 752242-26-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 109431-87-0 ]
  • [ 752242-26-5 ]
  • [ 1001420-31-0 ]
YieldReaction ConditionsOperation in experiment
92% With 4,4-(dimethyl-1,1-dioxido-1,2,5-thiadiazolidin-2-yl)-triphenyl phosphonium; In dichloromethane; toluene; at 20℃; for 3h; To a solution of Example 101 Part A compound (300 mg, 1.427 mmol) and (R) tert-butyl-3-hydroxypyrrolidine-carboxylate (534 m g, 2.85 mmol) in toluene (2 mL) was added a suspension of Example 97 Part B compound (1.17 g, 2.85 mmol) in DCM (2 mL). The reaction mixture was stirred at RT for 3 h, then was concentrated in vacuo. The residue was chromatographed (SiO2; continuous gradient 10% EtOAc/Hex to 60% EtOAc/Hexane) to give Part A compound (500 mg, 92%) as a white solid. [M+H]+=402; 1H NMR (400 MHz, CDCl3) δ 1.25 (d, J=6.15 Hz, 6 H), 1.39 (d, J=7.47 Hz, 9 H), 1.95-2.22 (m, 2 H), 3.25-3.46 (m, 4 H), 3.47-3.58 (m, 1 H), 3.82 (s, 3 H), 4.61-4.73 (m, 1 H), 5.07 (s, 1 H), 6.76 (t, J=2.42 Hz, 1 H), 7.00 (s, 1 H), 7.03 (s, 1 H).
 

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