Home Cart Sign in  
Chemical Structure| 75302-98-6 Chemical Structure| 75302-98-6

Structure of 75302-98-6

Chemical Structure| 75302-98-6

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 75302-98-6 ]

CAS No. :75302-98-6
Formula : C25H26ClNO6
M.W : 471.93
SMILES Code : O=C(OCC(OC(C)(C)C)=O)CC1=C(C)N(C(C2=CC=C(Cl)C=C2)=O)C3=C1C=C(OC)C=C3

Safety of [ 75302-98-6 ]

Application In Synthesis of [ 75302-98-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 75302-98-6 ]

[ 75302-98-6 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 75302-98-6 ]
  • [ 53164-05-9 ]
YieldReaction ConditionsOperation in experiment
80% With trifluoroacetic acid; In dichloromethane; at 20℃; for 48.0h; 55b. 2-(2-(1-((4-Chlorophenyl)carbonyl)-5-methoxy-2-methylindol-3-yl)acetyloxy)acetic Acid The product of Example 55a (6.12 g, 13 mmol) was dissolved in CH2Cl2 (50 mL) and TFA (15 mL) was added. The reaction mixture was stirred at room temperature for 2 days. The solvent and TFA were evaporated in vacuo and the residue obtained was dissolved in EtOAc (50 mL) and the solvent evaporated again to remove traces of trifluoroacetic acid. The residue obtained was recrystallized from EtOAc:hexane (1:4) to give the title compound (4.3 g, 80% yield) as a gray colored solid. Mp 137-138 C. 1H NMR (300 MHz, CDCl3) delta 8.93 (br s, 1H), 7.65 (d, J=8.4 Hz, 2H), 7.45 (d, J=8.4 Hz, 2H), 6.96 (d, J=2.3 Hz, 1H), 6.87 (d, J=9.0 Hz, 1H), 6.6 (dd, J=9.0 and 2.4 Hz, 1H), 4.67 (s, 2H), 3.81 (s, 3H), 3.78 (s, 2H), 2.36 (s, 3H); 13C NMR (75 MHz, CDCl3) delta 172.6, 170.3, 168.4, 155.9, 139.2, 136.1, 133.7, 131.1 (2*C), 130.7, 130.4, 129.1 (2*C), 114.9, 111.8, 111.7, 101.2, 60.5, 55.6, 29.6, 13.4; LRMS (APIMS) m/z 416 (MH+).
  • 2
  • [ 75302-98-6 ]
  • [ 53-86-1 ]
  • [ 53164-05-9 ]
YieldReaction ConditionsOperation in experiment
30%; 66% With iodine; aluminium; In acetonitrile; at 20℃; for 6.0h; To a suspension of AlI3 (2.0 mmol) in acetonitrile (20 mL) was charged ester 20 (0.943 g, 2.0 mmol). The mixture was stirred for 6h at 20 oC. After quenchingwith 2 M HCl (10 mL), the mixture was extracted by EA (50 mL × 3). The combined organic phase was washed with saturated aqueous Na2S2O3 (10 mL) to remove elementiodine. After evaporation of organic solvents, the residue was purified by flash column chromatography (PE/EA 3:2, EA was acidified with 1% formic acid) to afford indometacin22 (0.209 g, 30%) as a minor product, and 24 (0.554 g, 66%) as a yellow solid
 

Historical Records