* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
With N-iodo-succinimide; [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I) In dichloromethane; toluene at 20℃; for 14 h;
General procedure: To a stirred solution of the substrate (1 mmol) in CH2Cl2 or (CH2Cl)2 (0.1 M) were added Ph3PAuNTf2 (0.025 mmol, 19 mg; complex Ph3PAuNTf2 toluene, 2:1) followed by N-iodosuccinimide (1.1 mmol, 248 mg). The resulting solution was stirred at r.t. or under reflux until complete conversion of the starting material. After removal of the solvent under reduced pressure, the crude material was purified by flash column chromatography using different gradients of hexanes and EtOAc to obtain the pure desired products.
96 %Chromat.
With iodine; nitrosonium tetrafluoroborate In acetonitrile at 30℃; for 5 h; Sealed tube
To 45 mL of the reaction tube was added 0.5 mmol of 2-methylanisole, 0.25 mmol of I2, 1.5 mL of acetonitrile solution of nitrosonium tetrafluoroborate (1.5 mL of solution containing 0.1 mmol of nitrosonium tetrafluoroborate) The sealed reaction tube was subjected to a reaction under a magnetic stirring at a controlled temperature of 30 ° C for 5 hours, followed by cooling the reaction system to room temperature. The reaction mixture was purified by column chromatography to give 3-methyl-4-methoxyiodobenzene with a GC internal standard yield of 96percent. The structure of the product was determined using 1H-NMR and 13C-NMR, see Figure 5-6.
Reference：
[1] Synthetic Communications, 2003, vol. 33, # 8, p. 1319 - 1323
[2] Chemistry Letters, 1988, # 5, p. 795 - 798
[3] Synlett, 2014, vol. 25, # 3, p. 399 - 402
[4] Tetrahedron Letters, 1996, vol. 37, # 23, p. 4081 - 4084
[5] Journal of Organic Chemistry, 2006, vol. 71, # 11, p. 4349 - 4352
[6] Synthesis, 1995, # 10, p. 1273 - 1277
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[8] Synthetic Communications, 2005, vol. 35, # 10, p. 1313 - 1318
[9] Canadian Journal of Chemistry, 2005, vol. 83, # 10, p. 1808 - 1811
[10] Asian Journal of Chemistry, 2011, vol. 23, # 1, p. 41 - 43
[11] Tetrahedron Letters, 2003, vol. 44, # 49, p. 8781 - 8785
[12] Chinese Chemical Letters, 2012, vol. 23, # 3, p. 261 - 264
[13] Angewandte Chemie - International Edition, 2013, vol. 52, # 48, p. 12674 - 12678[14] Angew. Chem., 2013, vol. 125, # 48, p. 12906 - 12910
[15] Advanced Synthesis and Catalysis, 2013, vol. 355, # 17, p. 3437 - 3442
[16] Tetrahedron Letters, 2002, vol. 43, # 51, p. 9457 - 9459
[17] Synlett, 2003, # 12, p. 1895 - 1897
[18] Tetrahedron Letters, 2002, vol. 43, # 29, p. 5047 - 5048
[19] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1986, vol. 25, p. 1004 - 1005
[20] Chemistry - A European Journal, 2015, vol. 21, # 34, p. 11976 - 11979
[21] Bulletin of the Chemical Society of Japan, 1992, vol. 65, # 1, p. 306 - 308
[22] Recueil des Travaux Chimiques des Pays-Bas, 1931, vol. 50, p. 657,658
[23] Journal of the American Chemical Society, 1930, vol. 52, p. 1570
[24] Synthetic Communications, 2004, vol. 34, # 19, p. 3579 - 3585
[25] Patent: CN104230682, 2016, B, . Location in patent: Paragraph 0045; 0046
2
[ 60577-30-2 ]
[ 74-88-4 ]
[ 75581-11-2 ]
Reference：
[1] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 11, p. 2616 - 2621
[2] Angewandte Chemie - International Edition, 2012, vol. 51, # 9, p. 2225 - 2228
3
[ 6880-04-2 ]
[ 75581-11-2 ]
Reference：
[1] Journal of the American Chemical Society, 2017, vol. 139, # 33, p. 11527 - 11536
4
[ 578-58-5 ]
[ 75581-11-2 ]
[ 42298-41-9 ]
Reference：
[1] Journal of Organic Chemistry, 1995, vol. 60, # 24, p. 7953 - 7958
[2] Journal of Organic Chemistry, 1995, vol. 60, # 24, p. 7953 - 7958
5
[ 533-18-6 ]
[ 75581-11-2 ]
Reference：
[1] Journal of Organic Chemistry, 1951, vol. 16, p. 1117,1119
6
[ 855354-81-3 ]
[ 75581-11-2 ]
Reference：
[1] Journal of Organic Chemistry, 1951, vol. 16, p. 1117,1119
7
[ 60577-30-2 ]
[ 77-78-1 ]
[ 75581-11-2 ]
Reference：
[1] Journal of Organic Chemistry, 1951, vol. 16, p. 1117,1119
8
[ 110-86-1 ]
[ 578-58-5 ]
[ 7553-56-2 ]
[ 7697-37-2 ]
[ 75581-11-2 ]
Reference：
[1] Journal of the American Chemical Society, 1930, vol. 52, p. 1570
9
[ 696-62-8 ]
[ 369-57-3 ]
[ 613-37-6 ]
[ 28896-47-1 ]
[ 2974-94-9 ]
[ 87441-18-7 ]
[ 75581-11-2 ]
[ 87441-17-6 ]
Reference：
[1] Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1983, p. 803 - 808
With N-iodo-succinimide; [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); In dichloromethane; toluene; at 20℃; for 14h;
General procedure: To a stirred solution of the substrate (1 mmol) in CH2Cl2 or (CH2Cl)2 (0.1 M) were added Ph3PAuNTf2 (0.025 mmol, 19 mg; complex Ph3PAuNTf2 toluene, 2:1) followed by N-iodosuccinimide (1.1 mmol, 248 mg). The resulting solution was stirred at r.t. or under reflux until complete conversion of the starting material. After removal of the solvent under reduced pressure, the crude material was purified by flash column chromatography using different gradients of hexanes and EtOAc to obtain the pure desired products.
82%
With iodine; silver nitrate; In methanol; for 6h;Darkness;
To a solution of 2-methylanisole (0.3 mL, 2.42 mmol) in methanol (16.0 mL), silver nitrate (0.41 g, 2.42 mmol) and iodine (0.68 g, 2.66 mmol) were added. The suspension was stirred for 6 h in the dark. The reaction mixture was filtered and the solvent evaporated. The residue was extracted with water and dichloromethane, the organic layer was dried with anhydrous sodium sulfate and the solvent evaporated to give 4-iodo-1-methoxy-2-methylbenzene S1 as a white solid (0.49 g, 82%). mp 78 C (lit. 79-80 C) identical (NMR, MS) to that described.
96%Chromat.
With iodine; nitrosonium tetrafluoroborate; In acetonitrile; at 30℃; for 5h;Sealed tube;
To 45 mL of the reaction tube was added 0.5 mmol of 2-methylanisole, 0.25 mmol of I2, 1.5 mL of acetonitrile solution of nitrosonium tetrafluoroborate (1.5 mL of solution containing 0.1 mmol of nitrosonium tetrafluoroborate) The sealed reaction tube was subjected to a reaction under a magnetic stirring at a controlled temperature of 30 C for 5 hours, followed by cooling the reaction system to room temperature. The reaction mixture was purified by column chromatography to give 3-methyl-4-methoxyiodobenzene with a GC internal standard yield of 96%. The structure of the product was determined using 1H-NMR and 13C-NMR, see Figure 5-6.
[00359] In a reaction tube under nitrogen, a mixture of PdCl2(dppf)CH2Cl2 (21 mg; 0.026 mmol) and triethylamine (0.34 ml; 2.44 mmol) in dioxane (2.5 ml; dried over 4 A sieves) was sealed and stirred at 80 C. overnight (18 h). After cooling to room temperature, HB(pin) (0.19 ml; 1.31 mmol) was added followed by 1-iodo-4-methoxy-3-methylbenzene (215 mg; 0.867 mmol) in dioxane (2.5 ml; dried over 4 A sieves) and the reaction mixture was stirred at 80 C. GC analysis after 18 hours showed a single new peak at 11.4 minutes which was identified by GC/MS as the desired arylborate compound.
With caesium carbonate; In toluene; at 80℃; for 5h;Inert atmosphere;
In a typical reaction, styrene (1.0 mmol) and aryl halide (1.5 mmol) were reacted in a homogeneous mixture of toluene and PEG-600 (20 ml, 3:1) in the presence of 3 mol % of Cl2PdPEGD catalyst(34.4 mg) and Cs2CO3 (1.5 mmol), under a nitrogen atmosphere at 80 C for 5 h until complete consumption of aryl halide. The reaction progress was monitored by TLC and GC analysis. The mixture was cooled to room temperature and 20 ml of n-hexane was added to separate lower catalyst-philic PEG phase from upper product phase. The product was isolated by decantation and evaporation of solvents under vacuum. Catalyst-philic PEG phase containing polyether palladium catalyst was subjected to reuse by charging with the same amount of the substrates styrene (1.0 mmol) and aryl halide (1.5 mmol), Cs2CO3 (2.0 mmol) and toluene. The identity and purity of the products were confirmed by GC and GC-MS.
With norborn-2-ene; palladium diacetate; cesium pivalate; In N,N-dimethyl-formamide; at 105℃; for 24h;Inert atmosphere; Schlenk technique;
General procedure: A DMF solution (8mL) of the o-substituted aryl iodide (0.36mmol), the o-bromobenzyl alcohol (0.36mmol) and norbornene (34mg, 0.36mmol) was added under nitrogen to a Schlenck-type flask, containing Pd(OAc)2 (4mg, 0.018mmol), the phosphine (0.036mmol), when required, and K2CO3 (124mg, 0.90mmol) or CsOPiv (211mg, 0.90). The reaction mixture was stirred at 105C for 24h. After cooling to room temperature the organic layer was diluted with EtOAc (20mL), washed twice with water (20mL) and dried over Na2SO4. The solvent was removed under reduced pressure and the resulting residue was purified by flash chromatography on silica gel using mixtures of hexane-EtOAc as eluent.
5'-methoxy-3'-methyl-2'-d-[1,1']-biphenyl-2-carbaldehyde-formyl-d[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
85%
With norborn-2-ene; palladium diacetate; cesium pivalate; In N,N-dimethyl-formamide; at 105℃; for 24h;Inert atmosphere; Schlenk technique;
General procedure: A DMF solution (8mL) of the o-substituted aryl iodide (0.36mmol), the o-bromobenzyl alcohol (0.36mmol) and norbornene (34mg, 0.36mmol) was added under nitrogen to a Schlenck-type flask, containing Pd(OAc)2 (4mg, 0.018mmol), the phosphine (0.036mmol), when required, and K2CO3 (124mg, 0.90mmol) or CsOPiv (211mg, 0.90). The reaction mixture was stirred at 105C for 24h. After cooling to room temperature the organic layer was diluted with EtOAc (20mL), washed twice with water (20mL) and dried over Na2SO4. The solvent was removed under reduced pressure and the resulting residue was purified by flash chromatography on silica gel using mixtures of hexane-EtOAc as eluent.
With norborn-2-ene; trifuran-2-yl-phosphane; palladium diacetate; potassium carbonate; In N,N-dimethyl-formamide; at 105℃; for 24h;Inert atmosphere; Schlenk technique;
General procedure: A DMF solution (8mL) of the o-substituted aryl iodide (0.36mmol), the o-bromobenzyl alcohol (0.36mmol) and norbornene (34mg, 0.36mmol) was added under nitrogen to a Schlenck-type flask, containing Pd(OAc)2 (4mg, 0.018mmol), the phosphine (0.036mmol), when required, and K2CO3 (124mg, 0.90mmol) or CsOPiv (211mg, 0.90). The reaction mixture was stirred at 105C for 24h. After cooling to room temperature the organic layer was diluted with EtOAc (20mL), washed twice with water (20mL) and dried over Na2SO4. The solvent was removed under reduced pressure and the resulting residue was purified by flash chromatography on silica gel using mixtures of hexane-EtOAc as eluent.
ethyl 2,2-difluoro-2-(4-methoxy-3-methylphenyl)acetate[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
With copper; In N,N-dimethyl-formamide; at 80℃; for 36h;
Step 1 : Preparation of ethyl 2,2-difluoro-2-(4-methoxy-3-methylphenyl)acetateTo a solution 4-iodo-1 -methoxy-2-methylbenzene (commercially available, 1 equiv) and ethyl 2-bromo-2,2-difluoroacetate (2 equiv) in DMF (0.3M) was added Cu powder (3 equiv). The reaction slurry was heated to 80C for 1 .5 days, quenched with saturated NaH2P04 (aq) and extracted with ethyl acetate. The organics were dried over Na2S04 and concentrated under vacuum. The residual was purified via silica gel column chromatography to afford the title product.
(R)-(3-(benzyloxy)-2-((tert-butoxycarbonyl)amino)-3-oxopropyl)zinc(II) iodide[ No CAS ]
benzyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-methoxy-3-methylphenyl)propanoate[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
78%
With tris-(dibenzylideneacetone)dipalladium(0); tris-(o-tolyl)phosphine; In N,N-dimethyl-formamide; at 20℃;Inert atmosphere;
General procedure: Similar conditions for performing a Negishi coupling reaction with 15 have previously been described.4 A round bottom flask plus stir bar were dried and flushed with Ar before adding 1-iodo-3-isopropylbenzene (0.404 g, 1.64 mmol; purchased from Combi-Blocks) and anhyd. DMF (3 mL). Reaction was vacuum purged and refilled with Ar (3x) before the addition of Pd2dba3 (50 mg, 0.16 mmol) and P(o-tolyl)3 (75 mg, 0.082 mmol). A suspension containing organozinc 15 (5.5 mL, 2.5 mmol, 1.5 equiv.) was carefully added via syringe so as to avoid aspirating unreacted zinc metal. Reaction was stirred overnight at room temperature under Ar. Reaction mixture was quenched with sat. NH4Cl and extracted with EtOAc (2 x 15 mL). Organic phase was washed with brine, dried over MgSO4, filtered, concentrated and dried under high vacuum. Crude was purified by flash chromatography eluting with 5% EtOAc/Hexanes resulting in a beige solid: 277 mg (42%).
8-(4-methoxy-3-methylphenyl)-1,4-dioxaspiro[4.5]dec-7-ene[ No CAS ]
Yield
Reaction Conditions
Operation in experiment
81%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In 1,4-dioxane; water; at 50℃; for 2.5h;Inert atmosphere;
Step 1 : 8-(4-methoxy-3-methylphenyl)- 1 ,4-dioxaspiro [4.5] dec-7-ene [00412] A mixture of l,4-dioxa-spiro[4,5]dec-7-en-8-boronic acid pinacol ester (25.0 g, 93.9 mmol), 4-iodo-2-methylanisole (28.0 g, 113 mmol), l,l '-bis(diphenylphosphino)ferrocene dichlorlopalladium(II) (1.38 g, 1.89 mmol), dioxane (470 mL) and lM a2C03 (282 mL, 282 mmol) was degassed with vacuum/nitrogen cycles (3*), stirred at 50 C for 2.5 h, and then allowed to cool to rt. The mixture was diluted with ethyl acetate (500 mL) and washed with saturated NaHCCh (500 mL chi 2). The aqueous layers were back extracted with ethyl acetate (200 mL). The combined ethyl acetate extracts were dried ( a2S04), filtered, concentrated and purified by silica gel chromatography (0-5% ethyl acetate in hexanes) to give 8-(4-methoxy-3- methylphenyl)-l,4-dioxaspiro[4.5]dec-7-ene (19.9 g, 81%). NMR (400 MHz, DMSO-<&): delta 7.21-7.16 (m, 2H), 6.85 (d, 1H), 5.89-5.84 (m, 1H), 3.90 (s, 4H), 3.76 (s, 3H), 2.52-2.47 (m, 2H), 2.32 (br s, 2H), 2.13 (s, 3H), 1.77 (t, 2H); MS: 261.1 [M+H]+.
81%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In 1,4-dioxane; at 50℃; for 2.5h;Inert atmosphere;
j00452j A mixture of 1,4-dioxa-spiro[4,5]dec-7-en-8-boronic acid pinacol ester (25.0 g, 93.9 mmol), 4-iodo-2-methylanisole (28.0 g, 113 mmol), 1,1?-bis(diphenylphosphino)ferrocene dichloropalladium(II) (1.38 g, 1.89 mmol), dioxane (470 mL) and 1MNa2CO3 (282 mL, 282 mmol) was degassed with 3 vacuum/N2 cycles, stirred at 50 C for 2.5 h, and then allowed to cool to a The mixture was diluted with ethyl acetate (500 mL) and washed with saturated NaHCO3 (500 mL x 2). The aqueous layers were back extracted with ethyl acetate (200 mL). The combined ethyl acetate extracts were dried (Na2SO4), filtered, concentrated and purified by silica gel chromatography (0-5% ethyl acetate in hexanes) to give 8-(4-methoxy-3-methylphenyl)-1,4- dioxaspiro[4.5]dec-7-ene (19.9 g, 81%). ?H NMR (400 MHz, DMSO-d6): 7.21-7.16 (m, 2H), 6.85 (d, 1H), 5.89-5.84 (m, 1H), 3.90 (s, 4H), 3.76 (s, 3H), 2.52-2.47 (m, 2H), 2.32 (br s, 2H),2.13 (s, 3H), 1.77 (t, 2H); MS: 261.1 [M+H].
81%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In 1,4-dioxane; at 50℃; for 2.5h;Inert atmosphere;
A mixture of 1,4-dioxa-spiro[4,5]dec-7-en-8-boronic acid pinacol ester (25.0 g, 93.9 mmol), 4-iodo-2-methylanisole (28.0 g, 113 mmol), 1,1?-bis(diphenylphosphino)ferrocenedichlorlopalladium(II) (1.38 g, 1.89 mmol), dioxane (470 mL) and 1MNa2CO3 (282 mL, 282 mmol) was degassed with 3 vacuum/N2 cycles, stirred at 50 C for 2.5 h, and then allowed to cool to a The mixture was diluted with ethyl acetate (500 mL) and washed with saturated NaHCO3 (500 mL x 2). The aqueous layers were back extracted with ethyl acetate (200 mL). The combined ethyl acetate extracts were dried (Na2SO4), filtered, concentrated and purified by silica gel chromatography (0-5% ethyl acetate in hexanes) to give 8-(4-methoxy-3-methylphenyl)-1,4- dioxaspiro[4.5]dec-7-ene (19.9 g, 81%). ?H NMR (400 MHz, DMSO-d6): 7.21-7.16 (m, 2H), 6.85 (d, 1H), 5.89-5.84 (m, 1H), 3.90 (s, 4H), 3.76 (s, 3H), 2.52-2.47 (m, 2H), 2.32 (br s, 2H),2.13 (s, 3H), 1.77 (t, 2H); MS: 261.1 [M+H].
81%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In 1,4-dioxane; at 50℃; for 2.5h;Inert atmosphere;
A mixture of 1,4-dioxa-spiro[4,5]dec-7-en-8-boronic acid pinacol ester (25.0 g, 93.9 mmol), 4-iodo-2-methylanisole (28.0 g, 113 mmol), Pd(dppf)Cl2(1.38 g, 1.89 mmol), dioxane (470 mL) and 1M Na2C03(282 mL, 282 mmol) was degassed with 3 vacuum/N2cycles, stirred at 50 C for 2.5 h, and then allowed to cool to rt. The mixture was diluted with EtOAc (500 mL) and washed with saturated NaHC03(2x500 mL). The aqueous layers were back extracted with EtOAc (200 mL). The combined EtOAc extracts were dried (Na2S04), filtered, concentrated and purified by silica gel chromatography (0-5% EtOAc in hexanes) to give 8-(4-methoxy-3-methylphenyl)-l,4-dioxaspiro[4.5]dec-7-ene (19.9 g, 81%).1H MR (400 MHz, DMSO-i): delta 7.21-7.16 (m, 2H), 6.85 (d, 1H), 5.89-5.84 (m, 1H), 3.90 (s, 4H), 3.76 (s, 3H), 2.52-2.47 (m, 2H), 2.32 (br s, 2H), 2.13 (s, 3H), 1.77 (t, 2H); MS: 261.1[M+H]+.
81%
With sodium carbonate; In 1,4-dioxane; at 50℃; for 2.5h;Inert atmosphere;
A mixture of 1,4-dioxa-spiro[4,5]dec-7-en-8-boronic acid pinacol ester (25.0 g, 93.9 mmol), 4-iodo-2-methylanisole (28.0 g, 113 mmol), 1,1?-bis(diphenylphosphino)ferrocene dichlorlopalladium(II) (1.38 g, 1.89 mmol), dioxane (470 mL) and 1 MNa2CO3 (282 mL, 282 mmol) was degassed with 3 vacuum/N2 cycles, stirred at 50 C for 2.5 h, and then allowed to cool to a The mixture was diluted with EtOAc (500 mL) and washed with sat?d NaHCO3 (2x500 mL). The aqueous layers were back extracted with EtOAc (200 mL). The combined EtOAc extracts were dried (Na2SO4), filtered, concentrated and purified by silica gel chromatography (0-5% EtOAc in hexanes) to give 8-(4-methoxy-3-methylphenyl)-1,4- dioxaspiro[4.5]dec-7-ene (19.9 g, 81%). ?H NMR (400 MHz, DMSO-d6): 7.21-7.16 (m, 2H), 6.85 (d, 1H), 5.89-5.84 (m, 1H), 3.90 (s, 4H), 3.76 (s, 3H), 2.52-2.47 (m, 2H), 2.32 (br s, 2H), 2.13 (s, 3H), 1.77 (t, 2H); LCMS: 261.1 [M+H].
81%
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In 1,4-dioxane; at 50℃; for 2.5h;Inert atmosphere;
A mixture of 1,4-dioxa-spiro[4,5]dec-7-en-8-boronic acid pinacol ester (25.0 g, 93.9 mmol), 4-iodo-2-methylanisole (28.0 g, 113 mmol), Pd(dppf)Cl2 (1.38 g, 1.89 mmol), dioxane (470 mL) and 1 M Na2CO3 (282 mL, 282 mmol) was degassed with 3 vacuum/N2 cycles, stirred at 50 C. for 2.5 h, and then allowed to cool to rt. The mixture was diluted with EtOAc (500 mL) and washed with saturated NaHCO3 (2×500 mL). The aqueous layers were back extracted with EtOAc (200 mL). The combined EtOAc extracts were dried (Na2SO4), filtered, concentrated and purified by silica gel chromatography (0-5% EtOAc in hexanes) to give 8-(4-methoxy-3-methylphenyl)-1,4-dioxaspiro[4.5]dec-7-ene (19.9 g, 81%). 1H NMR (400 MHz, DMSO-d6): delta 7.21-7.16 (m, 2H), 6.85 (d, 1H), 5.89-5.84 (m, 1H), 3.90 (s, 4H), 3.76 (s, 3H), 2.52-2.47 (m, 2H), 2.32 (br s, 2H), 2.13 (s, 3H), 1.77 (t, 2H); LCMS: 261.1 [M+H]+.
trans-4-((tert-butyldimethylsilyl)oxy)-N-((trans-4-(4-methoxy-3-methylphenyl)cyclohexyl)methyl)-N-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclohexanecarboxamide[ No CAS ]
trans-4-((tert-butyldimethylsilyl)oxy)-N-((trans-4-(4-methoxy-3-methylphenyl)cyclohexyl)methyl)-N-(3-((trimethylsilyl)ethynyl)phenyl)cyclohexanecarboxamide[ No CAS ]
trans-4-((tert-butyldimethylsilyl)oxy)-N-((trans-4-(4-methoxy-3-methylphenyl)cyclohexyl)methyl)-N-(3-(4-methyl-1H-pyrazol-1-yl)phenyl)cyclohexanecarboxamide[ No CAS ]
trans-4-((tert-butyldimethylsilyl)oxy)-N-(3-(1-cyclopropyl-1H-pyrazol-4-yl)phenyl)-N-((trans-4-(4-methoxy-3-methylphenyl)cyclohexyl)methyl)cyclohexanecarboxamide[ No CAS ]
trans-4-((tert-butyldimethylsilyl)oxy)-N-((trans-4-(4-methoxy-3-methylphenyl)cyclohexyl)methyl)-N-(3-((1-methyl-1H-pyrazol-4-yl)ethynyl)phenyl)cyclohexane carboxamide[ No CAS ]
trans-4-hydroxy-N-((trans-4-(4-methoxy-3-methylphenyl)cyclohexyl)methyl)-N- (3-((1-methyl-1H-pyrazol-4-yl)ethynyl)phenyl)cyclohexanecarboxamide[ No CAS ]
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