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Chemical Structure| 760207-82-7 Chemical Structure| 760207-82-7

Structure of 760207-82-7

Chemical Structure| 760207-82-7

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Product Details of [ 760207-82-7 ]

CAS No. :760207-82-7
Formula : C8H10BrNO
M.W : 216.08
SMILES Code : CC1=CN=C(OCC)C(Br)=C1
MDL No. :MFCD11035733

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  • Downstream synthetic route of [ 760207-82-7 ]

[ 760207-82-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 17282-03-0 ]
  • [ 141-52-6 ]
  • [ 760207-82-7 ]
YieldReaction ConditionsOperation in experiment
72% In ethanol; at 100℃; for 48h;Inert atmosphere; 3-Bromo-2-ethoxy-5-methylpyridine To a solution of <strong>[17282-03-0]3-bromo-2-chloro-5-methylpyridine</strong> (4.00 g, 19.37 mmol) in ethanol (100 mL) was added sodium ethoxide (6.59 g, 96.9 mmol) in three portions. The mixture was stirred under nitrogen at 100 C. for 2 days. The reaction was cooled to room temperature, diluted with water and extracted with DCM. The combined organic layers were dried (Na2SO4), and the solvent was removed under reduced pressure. Purification (FCC, SiO2, 20%, EtOAc/hexanes) afforded the title compound (3.00 g, 72%). 1H NMR (400 MHz, DMSO-d6) delta 7.94 (dd, J=0.8, 2.3 Hz, 1H), 7.89-7.82 (m, 1H), 4.31 (q, J=7.0 Hz, 2H), 2.18 (t, J=0.8 Hz, 3H), 1.30 (t, J=7.0 Hz, 3H).
 

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