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Chemical Structure| 76492-19-8 Chemical Structure| 76492-19-8

Structure of 76492-19-8

Chemical Structure| 76492-19-8

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Product Details of [ 76492-19-8 ]

CAS No. :76492-19-8
Formula : C19H37N3O4
M.W : 371.51
SMILES Code : [C@H](C(N[C@H](C(OC)=O)CC(C)C)=O)(NC([C@H](CC(C)C)N)=O)CC(C)C
MDL No. :N/A

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Application In Synthesis of [ 76492-19-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 76492-19-8 ]

[ 76492-19-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 17191-44-5 ]
  • [ 76492-19-8 ]
  • C33H52N4O7 [ No CAS ]
YieldReaction ConditionsOperation in experiment
99% General procedure: N-(3-dimethylaminopropyl)-N?-ethylcarbodiimide hydrochloride (EDCI·HCl, 1.00 equiv) and 1-hydroxybenzotriazole hydrate (HOBt·H2O, 1.20 equiv) were added to the stirred solution of carboxylic acid (1.00 equiv) in CH2Cl2 (0.2 M) at 0 C, and the mixture was stirred at 0 C for 30 min. Then, a solution of amine in CH2Cl2 (0.2 M) was dropped to the reaction mixture at 0 C. In the case that the amine was used as a HCl salt, N,N-diisopropylethylamine (DIPEA, 2.40 equiv) was added. The reaction mixture was gradually warmed to room temperature and stirred overnight. After removal of CH2Cl2, the residue was diluted with EtOAc and washed successively with 1 M HCl, water, 5% aqueous NaHCO3, and brine. The organic layer was dried over Na2SO4 and concentrated in vacuo to give a crude product, which was purified by flash column chromatography on silica gel.
 

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