[ CAS No. 766-94-9 ] {[proInfo.proName]}

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Quality Control of [ 766-94-9 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 766-94-9 ]

SDS Specification

Alternatived Products of [ 766-94-9 ]

Product Details of [ 766-94-9 ]

CAS No. :	766-94-9	MDL No. :	MFCD00081208
Formula :	C₈H₈O	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	120.15	Pubchem ID :	-
Synonyms :

Safety of [ 766-94-9 ]

Signal Word:	Danger	Class:	3
Precautionary Statements:	P210-P233-P240-P241-P242-P243-P261-P264-P270-P272-P280-P301+P312+P330-P303+P361+P353-P333+P313-P363-P370+P378-P403+P235-P501	UN#:	3271
Hazard Statements:	H225-H302-H317	Packing Group:	Ⅱ
GHS Pictogram:

Application In Synthesis of [ 766-94-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 766-94-9 ]
Downstream synthetic route of [ 766-94-9 ]

[ 766-94-9 ] Synthesis Path-Upstream 1~2

1
[ 201230-82-2 ]
[ 766-94-9 ]
[ 52687-81-7 ]
[ 22409-86-5 ]

Reference： [1] Journal of Organometallic Chemistry, 1996, vol. 516, # 1-2, p. 235 - 243
[2] Tetrahedron Letters, 2000, vol. 41, # 19, p. 3717 - 3720
[3] Journal of Organic Chemistry, 2002, vol. 67, # 17, p. 6224 - 6225
[4] Advanced Synthesis and Catalysis, 2002, vol. 344, # 5, p. 556 - 562

2
[ 623-73-4 ]
[ 766-94-9 ]
[ 939-89-9 ]
[ 2120-93-6 ]

Reference： [1] Bulletin de la Societe Chimique de France, 1966, p. 717 - 728
[2] Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1958, vol. 246, p. 2897
[3] Gazzetta Chimica Italiana, 1956, vol. 86, p. 710,714, 720
[4] Journal of Organic Chemistry, 1958, vol. 23, p. 930

Yield	Reaction Conditions	Operation in experiment
80%	With potassium hydroxide semihydrate In dimethyl sulfoxide at 120℃; for 3h; Sealed tube;	Vinylation of phenols and naphthols with acetylene. General procedure. General procedure: In the reactor (0.3 L) was charged 50 mmol of ArOH 1, 1.62 g (25 mmol) of KOH*0.5H2O, 50 mL of DMSO, the reactor was closed gas-tight, the air was replaced by nitrogen, and acetylene was charged into the reactor to initial pressure 13-15 at. The reaction mixture at vigorous stirring (240 rpm) was heated at 120°C. The pressure in the reactor at the moment when the temperature reached the desired value was 15-16 at and decreased in the course of the reaction. At the completion of the experiment the reactor was cooled, the reaction mixture was diluted with 1% water solution of NH4Cl (100 mL), the reaction products were extracted with Et2O (6 × 30 mL). The extract was dried with Na2SO4, the solvent was distilled off on a rotary evaporator. The residue was distilled in a vacuum to obtain arylvinyl ethers 2a-2h. Divinyl ethers 4 and 5 were obtained similarly from dihydric phenols (50 mmol) and acetylene.
	With potassium hydroxide at 185℃;
	With potassium hydroxide; water at 175℃;

Yield	Reaction Conditions	Operation in experiment
1: 42% 2: 38%	With hydroquinone In o-xylene for 48h; Heating;

Yield	Reaction Conditions	Operation in experiment
65%	With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; In diethyl ether; water; at 20℃; for 4h;	Same procedure as in lit.32 with modifications: a biphasic solution of 2-bromo-1-phenoxy ethane32b (20.0 g, 0.1 mol), NBu4HSO4 (33 g, 0.1 mol) in Et2O (400 mL) and 50% aqueous NaOH (100 mL) was vigorously stirred at rt for 4 h. The organic phase was washed with H2O (3 × 50 mL), the aqueous phases were extracted with Et2O (2 × 50 mL), the combined organic phases dried (MgSO4) and evaporated. 27b was purified by distillation (7.8 g, 65%) at 70 C, 28 Torr. The reaction in toluene as in lit.32b gave a weaker yield (40%).1H NMR (250 MHz, CDCl3): similar values as in lit.37 S.-R. Sheng, X.-L. Liu, X.-C. Wang, Q. Xin and C.-S. Song, Synthesis (2004), pp. 2833-2836. Full Text via CrossRef \| View Record in Scopus \| Cited By in Scopus (21)37
20.1%	With potassium tert-butylate; In tetrahydrofuran; for 2h;Inert atmosphere; Reflux;	25 g of beta-bromophenethol and 25 g of t-BuOK were dissolved in THF (100 mL) and heated under reflux and inert atmosphere for 2 h. Afterwards the mixture was cooled, filtrated and concentrated. The mixture was diluted with diethyl ether and washed with water. The organic layer was dried over MgSO4. Finally, the colorless liquid was purified by distillation, yielding 3.01 g (20.1%)

Yield	Reaction Conditions	Operation in experiment
1: 10% 2: 60%	With pyridinium p-toluenesulfonate at 60 - 70℃; for 12h;

Yield	Reaction Conditions	Operation in experiment
74%	With toluene-4-sulfonic acid In toluene at 20℃; for 6h;

Yield	Reaction Conditions	Operation in experiment
	at 180 - 200℃; unter Druck; reagiert analog mit anderen Phenolen;

Yield	Reaction Conditions	Operation in experiment
1: 55% 2: 31%	Stage #1: vinyl phenyl ether With η5-cyclopentadienylbis(ethene)cobalt In tetrahydrofuran at 20℃; for 4h; Inert atmosphere; Stage #2: 2-(3-methoxyprop-1-yn-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane In tetrahydrofuran at -40 - 20℃; Inert atmosphere; Stage #3: With iron(III) chloride hexahydrate In acetonitrile at 20℃; Inert atmosphere; regioselective reaction;

Yield	Reaction Conditions	Operation in experiment
5.3%; 87.7%	With potassium hydroxide; In dimethyl sulfoxide; at 100℃; under 300.03 Torr; for 3h;Inert atmosphere;	Namely, 100.0 g (0.72 mol) of 2-phenoxyethanol, 400.0 g (5.11 mol) of dimethylsulfoxide ),8.8 g (0.14 mol) of potassium hydroxide was placed and the inside of the system was replaced with nitrogen gas while stirring at 600 rpm.Subsequently, after the temperature of the reaction solution was brought to 100 C.,The inside of the system was replaced with acetylene gas,While supplying acetylene continuously so as to be constant at a pressure of 0.04 MPa,The reaction was carried out at 100 C. for 3 hours.As a result of gas chromatographic analysis of the reaction solution,The conversion of raw material was 99.1%The yield of 2-phenoxyethyl vinyl ether was 87.7%, and the yield of phenyl vinyl ether was 5.3%.

Yield	Reaction Conditions	Operation in experiment
	With hydrazine hydrate; aluminium oxide nanoparticles In ethanol at 20℃; for 9h; Sealed tube; regioselective reaction;	Reaction procedure General procedure: A 20 mL slunk tube was charged with 30 mg of nano-Al2O3, followed by 1 mmol of styrene and 1 mL of ethanol in a standard reaction process. 2 mmol of hydrazine hydrate was added gradually to this slurry. The reactor was then sealed with a Teflon screw cover, and the reaction mixture was stirred for the 9-h period given in Table 1. GC was used to track the development of the reaction by sampling aliquots at various time intervals. Following completion of the reaction, the reactor was cooled to room temperature, and the reaction mixture was diluted with ethanol and filtered. The product was then subjected to GC analysis to determine conversion and selectivity. The obtained products were confirmed by the GC-MS technique. The above-mentioned experimental protocol was repeated for the reusability test, with the exception that the solid extracted after the reaction was washed twice with ACN and dried at 80 °C for three hours. This dried solid was utilized in subsequent cycles with a new substrate.

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Precautionary Statements-General
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P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
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P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
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P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
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P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
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P378
P380	Evacuate area.
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P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
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P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
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P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
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P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
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P401
P402	Store in a dry place.
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P413
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P422
P402 + P404	Store in a dry place. Store in a closed container.
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P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
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Physical hazards
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H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
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H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
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H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
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H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
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H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
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H361d	Suspected of damaging the unborn child
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H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

	at 270℃; Leiten ueber Zinkacetat/Kohle oder Cadmiumacetat/Bimsstein;
	With potassium hydroxide In dimethyl sulfoxide Inert atmosphere;

[ CAS No. 766-94-9 ] {[proInfo.proName]}

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Application In Synthesis of [ 766-94-9 ]

[ 766-94-9 ] Synthesis Path-Upstream 1~2

[ 766-94-9 ] Synthesis Path-Downstream 1~15

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