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Chemical Structure| 76746-16-2 Chemical Structure| 76746-16-2

Structure of 76746-16-2

Chemical Structure| 76746-16-2

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Product Details of [ 76746-16-2 ]

CAS No. :76746-16-2
Formula : C8H11N3O
M.W : 165.19
SMILES Code : O=C(NN)C1=CC=CC(C)=C1N

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Application In Synthesis of [ 76746-16-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 76746-16-2 ]

[ 76746-16-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 66176-17-8 ]
  • [ 76746-16-2 ]
YieldReaction ConditionsOperation in experiment
With hydrazine hydrate; In ethanol; at 20℃; for 2h; General procedure: To a solution of different substituted 2-aminobenzoic acid (3 mmol) in 15 mL of THF was added triphosgene (0.30 g, 1 mmol). The mixture was stirred at room temperature and monitored with TLC. After more than 4 h, the solvent was evaporated and the residue was dissolved in 15 mL of EtOH. The hydrazine hydrate (80 %) (0.94 g, 15 mmol) was added to this mixture dropwise. After 2 h, the reaction was completed, 30 mL of ethyl acetate was added. The solution was washed with 1 mol/L hydrochloric acid solution, saturated sodium bicarbonate solution, and brine. The ethyl acetate solution was dried and evaporated, and the residue was applied to a flash column chromatography by eluting with ethyl acetate to give the compounds 1a-f.
  • 2
  • [ 38980-96-0 ]
  • [ 76746-16-2 ]
  • 3-(4-trifluoromethylphenyl)-5-(2-amino-3-methylphenyl)-1,2,4-triazole [ No CAS ]
 

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